ID Q1LYI3_DANRE Unreviewed; 1552 AA. AC Q1LYI3; DT 30-MAY-2006, integrated into UniProtKB/TrEMBL. DT 10-JUL-2007, sequence version 2. DT 16-MAR-2016, entry version 82. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSDARP00000116253}; GN Name=hecw1b {ECO:0000313|Ensembl:ENSDARP00000116253, GN ECO:0000313|ZFIN:ZDB-GENE-060503-2}; GN Synonyms=hecw1 {ECO:0000313|ZFIN:ZDB-GENE-060503-2}, si:ch211-106n13.1 GN {ECO:0000313|ZFIN:ZDB-GENE-060503-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000116253, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000116253, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116253, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000116253} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000116253}; RG Ensembl; RL Submitted (AUG-2013) to UniProtKB. CC -!- SIMILARITY: Contains 1 C2 domain. {ECO:0000256|RuleBase:RU003412}. CC -!- SIMILARITY: Contains HECT (E6AP-type E3 ubiquitin-protein ligase) CC domain. {ECO:0000256|SAAS:SAAS00521535}. CC -!- CAUTION: The sequence shown here is derived from an Ensembl CC automatic analysis pipeline and should be considered as CC preliminary data. {ECO:0000313|Ensembl:ENSDARP00000116253}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX005176; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX324139; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001139236.1; NM_001145764.1. DR UniGene; Dr.155129; -. DR ProteinModelPortal; Q1LYI3; -. DR STRING; 7955.ENSDARP00000116253; -. DR PaxDb; Q1LYI3; -. DR Ensembl; ENSDART00000142835; ENSDARP00000116253; ENSDARG00000004291. DR GeneID; 563730; -. DR KEGG; dre:563730; -. DR CTD; 563730; -. DR ZFIN; ZDB-GENE-060503-2; hecw1b. DR eggNOG; KOG0940; Eukaryota. DR eggNOG; COG5021; LUCA. DR GeneTree; ENSGT00760000118966; -. DR HOGENOM; HOG000069940; -. DR HOVERGEN; HBG057414; -. DR InParanoid; Q1LYI3; -. DR KO; K12167; -. DR OMA; RTHYIRI; -. DR OrthoDB; EOG7BKCTS; -. DR PhylomeDB; Q1LYI3; -. DR TreeFam; TF313938; -. DR Reactome; R-DRE-4641258; Degradation of DVL. DR NextBio; 20885040; -. DR Proteomes; UP000000437; Chromosome 2. DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW. DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central. DR GO; GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:GO_Central. DR Gene3D; 2.60.40.150; -; 1. DR InterPro; IPR000008; C2_dom. DR InterPro; IPR000569; HECT_dom. DR InterPro; IPR032348; HECW_N. DR InterPro; IPR001202; WW_dom. DR Pfam; PF00168; C2; 1. DR Pfam; PF00632; HECT; 1. DR Pfam; PF16562; HECW_N; 1. DR Pfam; PF00397; WW; 1. DR SMART; SM00239; C2; 1. DR SMART; SM00119; HECTc; 1. DR SMART; SM00456; WW; 2. DR SUPFAM; SSF49562; SSF49562; 1. DR SUPFAM; SSF51045; SSF51045; 2. DR SUPFAM; SSF56204; SSF56204; 1. DR PROSITE; PS50004; C2; 1. DR PROSITE; PS50237; HECT; 1. DR PROSITE; PS01159; WW_DOMAIN_1; 2. DR PROSITE; PS50020; WW_DOMAIN_2; 2. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Ligase {ECO:0000256|SAAS:SAAS00521556}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Ubl conjugation pathway {ECO:0000256|SAAS:SAAS00521544}. FT DOMAIN 196 310 C2. {ECO:0000259|PROSITE:PS50004}. FT DOMAIN 770 803 WW. {ECO:0000259|PROSITE:PS50020}. FT DOMAIN 967 1000 WW. {ECO:0000259|PROSITE:PS50020}. FT DOMAIN 1217 1552 HECT (E6AP-type E3 ubiquitin-protein FT ligase). {ECO:0000259|PROSITE:PS50237}. SQ SEQUENCE 1552 AA; 175283 MW; EAA0E4AE10FB279D CRC64; MNEEVMIHRQ VILTQNLYQS RFLGLAAMAS PSRASQGRRR CKDPIRHSFN PEQFPNVDFQ NGVAEDLAAA VLRSTSDTDL LTSHCRSTLT VSTSSYTIGQ TQDITLSWDI KEEVDAGDWI GMYLIDEVLS ENFLDYKNRG VNGSHKGQII WKIEASSYFV EPETKICFKY YHGVSGALRA TTPCVTVKNP SAPVFKPVAT DDVPQSQGRR RLISFSLSDF QATGLKKGMF FNPDPYLKIA IHPGKHSIFP ALPHHGQEKR SGIVCNTINP VWQRERFNFV SLPTDVLEIE VKDKFAKSRP IIKRFLGKLS MPVQRLLEKH AIGDRVVSYT LGRRLPTEHV SGQLQFRFEI TSSIHPDDED MSLSTEQPVA AAEAQAQPQA EDTMSLDLGA PELPLDGDTA SVEMPMDVES GQSCAAEADV IEEECLEEEQ QEGEAAAAAA AMEQSETNAE ETTQVLDPIN GAEEEEAENN CAFAEESSDA RAGEEDEAIS DPQPASEEPD ADLEEDCSLR IRTTPRRKPR PCSLPVSELE TVIASACGEP ETPRSHYIRI HHLLHSLPAT QPQTGDSAGP EPDRPMGVEE EDEEEEEEGV TLEDHALTPN GPRRTLPRSR SHERLSDLIQ MLDGDGHPLG AEGQTGNQRS PDLSPVACCS HMSPRASGPI RAQSLDSARR SESTVFSSQD DEDEMEQPNG ILGSETETEQ GAQCREPGDG SCQWEEAPDS HVQSPHGIVG NGEVAGPSGR RECPLPCNHP AVSQLPALRP DPHHYPTIDE PLPPNWEARI DSHGRVFYVD HINRTTTWQR PTSAATPDGL RRSGSVQQME QLNRRYQTIQ RTMATERREE ESGSPRNDRT ANTETDSPLQ TNGDFTHITH NDRSSCSVKR LRRDTSCSPG HCQKITLLLQ SPAVKFITHP EFFTVLHANY GAYRMFTNSS CLKHMVLKIR RDARNFERYQ HNRDLVTFLN RFADAQLELP RGWEIKTDPQ GKSFFVDHNS RATTFIDPRI PLQNGRLPNH LTHRQHLQRL RSYSAGEASE VSRTRGVSLL ARPGNSLVAA IRNQSQQEPV PLAYNDKIVA FLRQPNIFEV LQERQPSFAR NHSLKDKVHH IRTEGTQRLE KLSCDADLVM LLSLFEEDIM SYVPLASFHP GFNFSPRCSP GSSPQNSPGT QRARAPAPYR RDFEAKLRNF YRKLEAKGYG QGPGKIKLIV RRDHLLEGTF NQVMAYSRKE LQRNKLYITF VGEEGLDYSG PSREFFFLLS QELFNPYYGL FEYSANDTYT VQISPMSAFV ENHLEWFRFS GRILGLALIH QYLLDAFFTR PFYKALLRLP TDLSDLEYLD EEFHQSLQWM KENDITDVLD LTFTVNEEVF GQVTERELKS GGTNVQVTEK NKKEYIERMV KWRVERGVVQ QTQALVRGFY EVVDSRLVSV FDARELELVI AGTAEIDLND WRNNTEYRGG YHDGHIVIRW FWGAVERFNN EQRLRLLQFV TGTSSVPYEG FTALRGSNGL RRFCIEKWGK ITSLPRAHTC FNRLDLPPYP SYTMLYEKLL IAVEETSTFG LE //