ID MEAK7_DANRE Reviewed; 450 AA. AC Q1LWV7; A0JMH4; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2006, sequence version 1. DT 25-MAY-2022, entry version 79. DE RecName: Full=MTOR-associated protein MEAK7 {ECO:0000305}; DE Short=MEAK7 {ECO:0000305}; DE AltName: Full=TBC/LysM-associated domain-containing protein 1; DE AltName: Full=TLD domain-containing protein 1; GN Name=meak7; Synonyms=KIAA1609, tldc1; GN ORFNames=si:ch211-260p9.6, zgc:153621; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Activates an alternative mTOR signaling to regulate cell CC proliferation and migration. {ECO:0000250|UniProtKB:Q6P9B6}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q6P9B6}. CC Cytoplasm {ECO:0000250|UniProtKB:Q6P9B6}. Lysosome CC {ECO:0000250|UniProtKB:Q6P9B6}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX511124; CAK04840.1; -; Genomic_DNA. DR EMBL; BC125880; AAI25881.1; -; mRNA. DR RefSeq; NP_001038430.2; NM_001044965.2. DR RefSeq; XP_017207426.1; XM_017351937.1. DR AlphaFoldDB; Q1LWV7; -. DR SMR; Q1LWV7; -. DR STRING; 7955.ENSDARP00000085993; -. DR PaxDb; Q1LWV7; -. DR Ensembl; ENSDART00000091560; ENSDARP00000085993; ENSDARG00000062951. DR Ensembl; ENSDART00000185684; ENSDARP00000152218; ENSDARG00000068763. DR GeneID; 561678; -. DR KEGG; dre:561678; -. DR CTD; 57707; -. DR ZFIN; ZDB-GENE-050419-140; meak7. DR eggNOG; KOG2557; Eukaryota. DR GeneTree; ENSGT00940000157517; -. DR GeneTree; ENSGT00940000158087; -. DR HOGENOM; CLU_036763_2_0_1; -. DR InParanoid; Q1LWV7; -. DR OMA; VIEDWVF; -. DR OrthoDB; 585082at2759; -. DR PhylomeDB; Q1LWV7; -. DR TreeFam; TF316541; -. DR PRO; PR:Q1LWV7; -. DR Proteomes; UP000000437; Chromosome 18. DR Bgee; ENSDARG00000062951; Expressed in blastula and 26 other tissues. DR ExpressionAtlas; Q1LWV7; baseline and differential. DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB. DR GO; GO:0016020; C:membrane; ISS:UniProtKB. DR GO; GO:0150032; P:positive regulation of protein localization to lysosome; ISS:UniProtKB. DR GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB. DR GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB. DR GO; GO:0043200; P:response to amino acid; ISS:UniProtKB. DR GO; GO:0032868; P:response to insulin; ISS:UniProtKB. DR GO; GO:0031667; P:response to nutrient levels; ISS:UniProtKB. DR GO; GO:0031929; P:TOR signaling; ISS:UniProtKB. DR InterPro; IPR006571; TLDc_dom. DR Pfam; PF07534; TLD; 1. DR SMART; SM00584; TLDc; 1. DR PROSITE; PS51886; TLDC; 1. PE 2: Evidence at transcript level; KW Cytoplasm; Lysosome; Membrane; Reference proteome. FT CHAIN 1..450 FT /note="MTOR-associated protein MEAK7" FT /id="PRO_0000313643" FT DOMAIN 236..404 FT /note="TLDc" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234" FT REGION 430..450 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CONFLICT 153 FT /note="H -> Q (in Ref. 2; AAI25881)" FT /evidence="ECO:0000305" FT CONFLICT 182 FT /note="S -> T (in Ref. 2; AAI25881)" FT /evidence="ECO:0000305" FT CONFLICT 294 FT /note="Y -> H (in Ref. 2; AAI25881)" FT /evidence="ECO:0000305" FT CONFLICT 300 FT /note="S -> A (in Ref. 2; AAI25881)" FT /evidence="ECO:0000305" FT CONFLICT 448 FT /note="D -> G (in Ref. 2; AAI25881)" FT /evidence="ECO:0000305" SQ SEQUENCE 450 AA; 49949 MW; 25AC1E9EA640DF9B CRC64; MGNGDSVVAQ KRLARFRPDE RPAVEGTFDR LHGARSSASA GKTSKGLSLD MLQLTMGKMA SESMIKRVFQ GLHSIDPGVP LHPGDGVSRE QLLIFLADVL RGTAEERAPL VLAMAEGAKA TVTTTEQIRG FMEDLVYAAV QTLAHKGHLR AWHPERMGDG AQGVKLLAEQ LTSELKPSDQ NSCDIACLED WLFRIPMMAM FLELLIGEGL GVVLPSRPPP TLLPPCQFAP WTDLRCVLSL PLLMFLSPLL PEGHSAPWRM LFSTKMHGES FTRLLGSCKS RGPTVLLVKD TKGYIFGGFS SQSWEVKPQF QGDSRCFLFS VFPYMRVFTC TGYNDHYMYL NQGQQTMPNG LGMGGQHGYF GLWLDYDFGH GHSRARPRCT TYGSPQLSAD EDFKLDTLEV WGVGKLPEEQ EEDEKKKSIL DADLEVQAMM EMTGKTLHSQ GLREPEEDED //