ID TLDC1_DANRE Reviewed; 450 AA. AC Q1LWV7; A0JMH4; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2006, sequence version 1. DT 13-FEB-2019, entry version 68. DE RecName: Full=TLD domain-containing protein 1; DE AltName: Full=TBC/LysM-associated domain-containing protein 1; GN Name=tldc1; ORFNames=si:ch211-260p9.6, zgc:153621; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., RA Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., RA Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., RA Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., RA Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., RA Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., RA Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., RA Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., RA Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., RA Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., RA Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., RA Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., RA Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., RA Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q6P9B6}. CC Cytoplasm {ECO:0000250|UniProtKB:Q6P9B6}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX511124; CAK04840.1; -; Genomic_DNA. DR EMBL; BC125880; AAI25881.1; -; mRNA. DR RefSeq; NP_001038430.2; NM_001044965.2. DR RefSeq; XP_017207426.1; XM_017351937.1. DR UniGene; Dr.43652; -. DR SMR; Q1LWV7; -. DR PaxDb; Q1LWV7; -. DR Ensembl; ENSDART00000091560; ENSDARP00000085993; ENSDARG00000062951. DR Ensembl; ENSDART00000185684; ENSDARP00000152218; ENSDARG00000068763. DR GeneID; 561678; -. DR KEGG; dre:561678; -. DR CTD; 57707; -. DR ZFIN; ZDB-GENE-050419-140; meak7. DR eggNOG; KOG2557; Eukaryota. DR eggNOG; ENOG410XR8F; LUCA. DR GeneTree; ENSGT00940000157517; -. DR GeneTree; ENSGT00940000158087; -. DR HOGENOM; HOG000031408; -. DR HOVERGEN; HBG103322; -. DR InParanoid; Q1LWV7; -. DR OMA; KPQFQGD; -. DR OrthoDB; 585082at2759; -. DR PhylomeDB; Q1LWV7; -. DR TreeFam; TF316541; -. DR PRO; PR:Q1LWV7; -. DR Proteomes; UP000000437; Chromosome 18. DR Bgee; ENSDARG00000062951; Expressed in 17 organ(s), highest expression level in liver. DR ExpressionAtlas; Q1LWV7; baseline and differential. DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB. DR GO; GO:0016020; C:membrane; ISS:UniProtKB. DR InterPro; IPR006571; TLDc_dom. DR Pfam; PF07534; TLD; 1. DR SMART; SM00584; TLDc; 1. PE 2: Evidence at transcript level; KW Complete proteome; Cytoplasm; Membrane; Reference proteome. FT CHAIN 1 450 TLD domain-containing protein 1. FT /FTId=PRO_0000313643. FT DOMAIN 260 404 TLD. FT CONFLICT 153 153 H -> Q (in Ref. 2; AAI25881). FT {ECO:0000305}. FT CONFLICT 182 182 S -> T (in Ref. 2; AAI25881). FT {ECO:0000305}. FT CONFLICT 294 294 Y -> H (in Ref. 2; AAI25881). FT {ECO:0000305}. FT CONFLICT 300 300 S -> A (in Ref. 2; AAI25881). FT {ECO:0000305}. FT CONFLICT 448 448 D -> G (in Ref. 2; AAI25881). FT {ECO:0000305}. SQ SEQUENCE 450 AA; 49949 MW; 25AC1E9EA640DF9B CRC64; MGNGDSVVAQ KRLARFRPDE RPAVEGTFDR LHGARSSASA GKTSKGLSLD MLQLTMGKMA SESMIKRVFQ GLHSIDPGVP LHPGDGVSRE QLLIFLADVL RGTAEERAPL VLAMAEGAKA TVTTTEQIRG FMEDLVYAAV QTLAHKGHLR AWHPERMGDG AQGVKLLAEQ LTSELKPSDQ NSCDIACLED WLFRIPMMAM FLELLIGEGL GVVLPSRPPP TLLPPCQFAP WTDLRCVLSL PLLMFLSPLL PEGHSAPWRM LFSTKMHGES FTRLLGSCKS RGPTVLLVKD TKGYIFGGFS SQSWEVKPQF QGDSRCFLFS VFPYMRVFTC TGYNDHYMYL NQGQQTMPNG LGMGGQHGYF GLWLDYDFGH GHSRARPRCT TYGSPQLSAD EDFKLDTLEV WGVGKLPEEQ EEDEKKKSIL DADLEVQAMM EMTGKTLHSQ GLREPEEDED //