ID YJEN3_DANRE Reviewed; 246 AA. AC Q1LVI2; DT 12-AUG-2020, integrated into UniProtKB/Swiss-Prot. DT 30-MAY-2006, sequence version 1. DT 24-JUL-2024, entry version 104. DE RecName: Full=YjeF N-terminal domain-containing 3; DE AltName: Full=ApoA-I-binding protein 2 {ECO:0000303|PubMed:30705153}; GN Name=yjefn3 {ECO:0000312|ZFIN:ZDB-GENE-050208-755}; GN Synonyms=aibp2 {ECO:0000303|PubMed:23719382, ECO:0000303|PubMed:30705153}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] RP FUNCTION, DEVELOPMENTAL STAGE, INTERACTION WITH APOA1A, BINDS TO HDL, AND RP DISRUPTION PHENOTYPE. RX PubMed=23719382; DOI=10.1038/nature12166; RA Fang L., Choi S.H., Baek J.S., Liu C., Almazan F., Ulrich F., Wiesner P., RA Taleb A., Deer E., Pattison J., Torres-Vazquez J., Li A.C., Miller Y.I.; RT "Control of angiogenesis by AIBP-mediated cholesterol efflux."; RL Nature 498:118-122(2013). RN [3] RP FUNCTION, AND DISRUPTION PHENOTYPE. RX PubMed=30705153; DOI=10.1126/science.aav1749; RA Gu Q., Yang X., Lv J., Zhang J., Xia B., Kim J.D., Wang R., Xiong F., RA Meng S., Clements T.P., Tandon B., Wagner D.S., Diaz M.F., Wenzel P.L., RA Miller Y.I., Traver D., Cooke J.P., Li W., Zon L.I., Chen K., Bai Y., RA Fang L.; RT "AIBP-mediated cholesterol efflux instructs hematopoietic stem and RT progenitor cell fate."; RL Science 363:1085-1088(2019). CC -!- FUNCTION: Accelerates cholesterol efflux from endothelial cells to CC high-density lipoprotein (HDL) and thereby regulates angiogenesis CC (PubMed:23719382). Orchestrates hematopoietic stem and progenitor cell CC emergence from the hemogenic endothelium, a type of specialized CC endothelium manifesting hematopoietic potential. YJEFN3-mediated CC cholesterol efflux activates endothelial SREBF2, the master CC transcription factor for cholesterol biosynthesis, which in turn CC transactivates NOTCH and promotes hematopoietic stem and progenitor CC cell emergence (PubMed:30705153). {ECO:0000269|PubMed:23719382, CC ECO:0000269|PubMed:30705153}. CC -!- SUBUNIT: Interacts with apoa1a (PubMed:23719382). Binds to high-density CC lipoprotein (PubMed:23719382). {ECO:0000269|PubMed:23719382}. CC -!- DEVELOPMENTAL STAGE: Expression in 24-36 hours post-fertilization (hpf) CC embryos shows a clear segmental pattern. By 48 hpf, when segmental CC angiogenesis is completed, is no longer expressed in somites. CC {ECO:0000269|PubMed:23719382}. CC -!- DISRUPTION PHENOTYPE: Morpholino knockdowns have a reduced number of CC nascent hematopoietic stem cells in the ventral dorsal aorta between 28 CC and 60 hours post-fertilization (hpf) (PubMed:23719382, CC PubMed:30705153). Morpholino knockdowns show increased levels of free CC (unesterified) cholesterol (PubMed:23719382, PubMed:30705153). CC {ECO:0000269|PubMed:23719382, ECO:0000269|PubMed:30705153}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX649279; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX664610; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001038308.1; NM_001044843.1. DR AlphaFoldDB; Q1LVI2; -. DR SMR; Q1LVI2; -. DR STRING; 7955.ENSDARP00000082703; -. DR PaxDb; 7955-ENSDARP00000082703; -. DR GeneID; 557840; -. DR KEGG; dre:557840; -. DR AGR; ZFIN:ZDB-GENE-050208-755; -. DR CTD; 374887; -. DR ZFIN; ZDB-GENE-050208-755; yjefn3. DR eggNOG; KOG2585; Eukaryota. DR HOGENOM; CLU_024853_3_0_1; -. DR InParanoid; Q1LVI2; -. DR OMA; HSCAMAV; -. DR OrthoDB; 1493at2759; -. DR PhylomeDB; Q1LVI2; -. DR TreeFam; TF300197; -. DR PRO; PR:Q1LVI2; -. DR Proteomes; UP000000437; Chromosome 22. DR Bgee; ENSDARG00000061692; Expressed in brain and 12 other cell types or tissues. DR GO; GO:0052856; F:NADHX epimerase activity; IBA:GO_Central. DR GO; GO:0071425; P:hematopoietic stem cell proliferation; IMP:UniProtKB. DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW. DR GO; GO:0031580; P:membrane raft distribution; IMP:ZFIN. DR GO; GO:0016525; P:negative regulation of angiogenesis; IMP:ZFIN. DR GO; GO:0010874; P:regulation of cholesterol efflux; IMP:UniProtKB. DR GO; GO:0008593; P:regulation of Notch signaling pathway; IMP:UniProtKB. DR GO; GO:0002040; P:sprouting angiogenesis; IMP:ZFIN. DR Gene3D; 3.40.50.10260; YjeF N-terminal domain; 1. DR InterPro; IPR004443; YjeF_N_dom. DR InterPro; IPR036652; YjeF_N_dom_sf. DR InterPro; IPR032976; YJEFN_prot_NAXE-like. DR NCBIfam; TIGR00197; yjeF_nterm; 1. DR PANTHER; PTHR13232; NAD(P)H-HYDRATE EPIMERASE; 1. DR PANTHER; PTHR13232:SF12; YJEF N-TERMINAL DOMAIN-CONTAINING PROTEIN 3; 1. DR Pfam; PF03853; YjeF_N; 1. DR SUPFAM; SSF64153; YjeF N-terminal domain-like; 1. DR PROSITE; PS51385; YJEF_N; 1. PE 1: Evidence at protein level; KW Lipid transport; Reference proteome; Transport. FT CHAIN 1..246 FT /note="YjeF N-terminal domain-containing 3" FT /id="PRO_0000450455" FT DOMAIN 24..234 FT /note="YjeF N-terminal" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00719" SQ SEQUENCE 246 AA; 27609 MW; AD6F399AAB25EE3D CRC64; MNHSSNEKEP ETIEPLRYLS KTEVATVETE LLRDYRFGQQ QLIEIWGHAC AIAITKAFPL SSLSKKQPTL LVVCGPEQNG SIGLVCARHL RMFEYEPTIF YPKRSTLGLH QDFTVQCEKM DIPFLSYLPT EVQLLNDAYN LVIDAILGPE TDHKDVKEPY AGMLVTLKQV KIPIVSVDVP SGWDADEPAK DGINPEVLIS LTAPKKCATG FSGKHFLAGR FLPYDIQKKY ELNLPEFPGT ECIIEL //