ID   Q1JPZ8_DANRE            Unreviewed;       327 AA.
AC   Q1JPZ8;
DT   13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2006, sequence version 1.
DT   24-JUL-2024, entry version 122.
DE   RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE            EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN   Name=ppp1cb {ECO:0000313|EMBL:AAI16540.1,
GN   ECO:0000313|RefSeq:NP_001004527.2,
GN   ECO:0000313|ZFIN:ZDB-GENE-030616-609};
GN   Synonyms=ik:tdsubc_2f2 {ECO:0000313|RefSeq:NP_001004527.2},
GN   si:zc214p16.4 {ECO:0000313|RefSeq:NP_001004527.2}, wu:fa09h01
GN   {ECO:0000313|RefSeq:NP_001004527.2}, wu:fa11e06
GN   {ECO:0000313|RefSeq:NP_001004527.2}, xx:tdsubc_2f2
GN   {ECO:0000313|RefSeq:NP_001004527.2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI16540.1};
RN   [1] {ECO:0000313|RefSeq:NP_001004527.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16109975;
RA   Woods I.G., Wilson C., Friedlander B., Chang P., Reyes D.K., Nix R.,
RA   Kelly P.D., Chu F., Postlethwait J.H., Talbot W.S.;
RT   "The zebrafish gene map defines ancestral vertebrate chromosomes.";
RL   Genome Res. 15:1307-1314(2005).
RN   [2] {ECO:0000313|EMBL:AAI16540.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Skin {ECO:0000313|EMBL:AAI16540.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001004527.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=18776143;
RA   Huang H., Ruan H., Aw M.Y., Hussain A., Guo L., Gao C., Qian F., Leung T.,
RA   Song H., Kimelman D., Wen Z., Peng J.;
RT   "Mypt1-mediated spatial positioning of Bmp2-producing cells is essential
RT   for liver organogenesis.";
RL   Development 135:3209-3218(2008).
RN   [4] {ECO:0000313|RefSeq:NP_001004527.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19515695;
RA   Weiser D.C., Row R.H., Kimelman D.;
RT   "Rho-regulated myosin phosphatase establishes the level of protrusive
RT   activity required for cell movements during zebrafish gastrulation.";
RL   Development 136:2375-2384(2009).
RN   [5] {ECO:0000313|RefSeq:NP_001004527.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22205629;
RA   Levi L., Ziv T., Admon A., Levavi-Sivan B., Lubzens E.;
RT   "Insight into molecular pathways of retinal metabolism, associated with
RT   vitellogenesis in zebrafish.";
RL   Am. J. Physiol. Endocrinol. Metab. 302:E626-E644(2012).
RN   [6] {ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [7] {ECO:0000313|RefSeq:NP_001004527.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24040418;
RA   Jayashankar V., Nguyen M.J., Carr B.W., Zheng D.C., Rosales J.B.,
RA   Rosales J.B., Weiser D.C.;
RT   "Protein phosphatase 1 beta paralogs encode the zebrafish myosin
RT   phosphatase catalytic subunit.";
RL   PLoS ONE 8:e75766-e75766(2013).
RN   [8] {ECO:0000313|RefSeq:NP_001004527.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [9] {ECO:0000313|RefSeq:NP_001004527.2}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28252024;
RA   Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA   Choudhary J.S., Emes R.D., Grant S.G.;
RT   "Evolution of complexity in the zebrafish synapse proteome.";
RL   Nat. Commun. 8:14613-14613(2017).
RN   [10] {ECO:0000313|RefSeq:NP_001004527.2}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (APR-2024) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:83421; EC=3.1.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00001512};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:61977; EC=3.1.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00001482,
CC         ECO:0000256|RuleBase:RU004273};
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-1 subfamily.
CC       {ECO:0000256|ARBA:ARBA00005333}.
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DR   EMBL; BC116539; AAI16540.1; -; mRNA.
DR   RefSeq; NP_001004527.2; NM_001004527.3.
DR   GeneID; 100003223; -.
DR   KEGG; dre:100003223; -.
DR   AGR; ZFIN:ZDB-GENE-030616-609; -.
DR   CTD; 5500; -.
DR   ZFIN; ZDB-GENE-030616-609; ppp1cb.
DR   OrthoDB; 19833at2759; -.
DR   Proteomes; UP000000437; Chromosome 17.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046982; F:protein heterodimerization activity; IPI:ZFIN.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0032922; P:circadian regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0060028; P:convergent extension involved in axis elongation; IMP:ZFIN.
DR   GO; GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0001889; P:liver development; IMP:ZFIN.
DR   GO; GO:0042752; P:regulation of circadian rhythm; IBA:GO_Central.
DR   CDD; cd07414; MPP_PP1_PPKL; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR050341; PP1_catalytic_subunit.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   InterPro; IPR031675; STPPase_N.
DR   PANTHER; PTHR11668; SERINE/THREONINE PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR11668:SF449; SERINE_THREONINE-PROTEIN PHOSPHATASE; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF16891; STPPase_N; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Glycogen metabolism {ECO:0000256|ARBA:ARBA00022600};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004273};
KW   Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q1JPZ8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN          120..125
FT                   /note="Serine/threonine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS00125"
FT   REGION          305..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  37142 MW;  334480C886E5A195 CRC64;
     MAEGELNVDS LISRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI
     CGDIHGQYTD LLRLFEYGGF PPEANNLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL
     RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIIDEKIFC CHGGLSPDLQ
     SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL
     DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDESLMC SFQILKPSEK
     KAKYQYSGVN SGRPVTPPRT AQAPKKR
//