ID Q1JPZ8_DANRE Unreviewed; 327 AA. AC Q1JPZ8; DT 13-JUN-2006, integrated into UniProtKB/TrEMBL. DT 13-JUN-2006, sequence version 1. DT 26-FEB-2020, entry version 101. DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273}; DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273}; GN Name=ppp1cb {ECO:0000313|EMBL:AAI16540.1, GN ECO:0000313|ZFIN:ZDB-GENE-030616-609}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI16540.1}; RN [1] {ECO:0000313|EMBL:AAI16540.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Skin {ECO:0000313|EMBL:AAI16540.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:83421; EC=3.1.3.16; CC Evidence={ECO:0000256|SAAS:SAAS01116782}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA- CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:61977; EC=3.1.3.16; CC Evidence={ECO:0000256|RuleBase:RU004273, CC ECO:0000256|SAAS:SAAS01116780}; CC -!- SIMILARITY: Belongs to the PPP phosphatase family. CC {ECO:0000256|RuleBase:RU004273, ECO:0000256|SAAS:SAAS01017257}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC116539; AAI16540.1; -; mRNA. DR RefSeq; NP_001004527.2; NM_001004527.3. DR GeneID; 100003223; -. DR KEGG; dre:100003223; -. DR CTD; 5500; -. DR ZFIN; ZDB-GENE-030616-609; ppp1cb. DR eggNOG; ENOG410IN85; Eukaryota. DR eggNOG; ENOG410XPVF; LUCA. DR KO; K06269; -. DR OrthoDB; 766640at2759; -. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0046982; F:protein heterodimerization activity; IPI:ZFIN. DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central. DR GO; GO:0032922; P:circadian regulation of gene expression; IBA:GO_Central. DR GO; GO:0060028; P:convergent extension involved in axis elongation; IMP:ZFIN. DR GO; GO:0001889; P:liver development; IMP:ZFIN. DR GO; GO:0042752; P:regulation of circadian rhythm; IBA:GO_Central. DR Gene3D; 3.60.21.10; -; 1. DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH. DR InterPro; IPR029052; Metallo-depent_PP-like. DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase. DR InterPro; IPR031675; STPPase_N. DR Pfam; PF00149; Metallophos; 1. DR Pfam; PF16891; STPPase_N; 1. DR PRINTS; PR00114; STPHPHTASE. DR SMART; SM00156; PP2Ac; 1. DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1. PE 2: Evidence at transcript level; KW Hydrolase {ECO:0000256|RuleBase:RU004273, ECO:0000256|SAAS:SAAS01017252}; KW Manganese {ECO:0000256|SAAS:SAAS01017251}; KW Metal-binding {ECO:0000256|SAAS:SAAS01017255}; KW Protein phosphatase {ECO:0000256|SAAS:SAAS01017274}. FT DOMAIN 120..125 FT /note="SER_THR_PHOSPHATASE" FT /evidence="ECO:0000259|PROSITE:PS00125" FT REGION 305..327 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 327 AA; 37142 MW; 334480C886E5A195 CRC64; MAEGELNVDS LISRLLEVRG CRPGKIVQMT EAEVRGLCIK SREIFLSQPI LLELEAPLKI CGDIHGQYTD LLRLFEYGGF PPEANNLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL RGNHECASIN RIYGFYDECK RRFNIKLWKT FTDCFNCLPI AAIIDEKIFC CHGGLSPDLQ SMEQIRRIMR PTDVPDTGLL CDLLWSDPDK DVQGWGENDR GVSFTFGADV VSKFLNRHDL DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGG MMSVDESLMC SFQILKPSEK KAKYQYSGVN SGRPVTPPRT AQAPKKR //