ID Q1HSF8_9HIV1 Unreviewed; 846 AA. AC Q1HSF8; DT 13-JUN-2006, integrated into UniProtKB/TrEMBL. DT 13-JUN-2006, sequence version 1. DT 11-MAY-2016, entry version 75. DE RecName: Full=Endogenous retrovirus group K member 7 Env polyprotein {ECO:0000256|SAAS:SAAS00159103}; DE AltName: Full=Endogenous retrovirus group K member 113 Env polyprotein {ECO:0000256|SAAS:SAAS00159454}; DE AltName: Full=Endogenous retrovirus group K member 13-1 Env polyprotein {ECO:0000256|SAAS:SAAS00411892}; DE AltName: Full=Endogenous retrovirus group K member 18 Env polyprotein {ECO:0000256|SAAS:SAAS00159191}; DE AltName: Full=Endogenous retrovirus group K member 19 Env polyprotein {ECO:0000256|SAAS:SAAS00411904}; DE AltName: Full=Endogenous retrovirus group K member 21 Env polyprotein {ECO:0000256|SAAS:SAAS00159138}; DE AltName: Full=Endogenous retrovirus group K member 24 Env polyprotein {ECO:0000256|SAAS:SAAS00159416}; DE AltName: Full=Endogenous retrovirus group K member 25 Env polyprotein {ECO:0000256|SAAS:SAAS00411846}; DE AltName: Full=Endogenous retrovirus group K member 6 Env polyprotein {ECO:0000256|SAAS:SAAS00411868}; DE AltName: Full=Endogenous retrovirus group K member 8 Env polyprotein {ECO:0000256|SAAS:SAAS00159133}; DE AltName: Full=Endogenous retrovirus group K member 9 Env polyprotein {ECO:0000256|SAAS:SAAS00159347}; DE AltName: Full=Envelope glycoprotein gp160 {ECO:0000256|SAAS:SAAS00411610}; GN Name=env {ECO:0000313|EMBL:ABE03508.1}; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ABE03508.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:ABE03508.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=C61v1e3 {ECO:0000313|EMBL:ABE03508.1}; RX PubMed=16641269; DOI=10.1128/JVI.80.10.4758-4770.2006; RA Bailey J.R., Lassen K.G., Yang H.C., Quinn T.C., Ray S.C., RA Blankson J.N., Siliciano R.F.; RT "Neutralizing antibodies do not mediate suppression of human RT immunodeficiency virus type 1 in elite suppressors or selection of RT plasma virus variants in patients on highly active antiretroviral RT therapy."; RL J. Virol. 80:4758-4770(2006). CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00595805}; Peripheral membrane protein CC {ECO:0000256|SAAS:SAAS00595805}. CC -!- SUBCELLULAR LOCATION: Host cell membrane CC {ECO:0000256|SAAS:SAAS00595638}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00595638}. CC -!- SUBCELLULAR LOCATION: Host endosome membrane CC {ECO:0000256|SAAS:SAAS00595816}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00595816}. CC -!- SUBCELLULAR LOCATION: Virion membrane CC {ECO:0000256|SAAS:SAAS00595588}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS00595588}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ410516; ABE03508.1; -; Genomic_RNA. DR ProteinModelPortal; Q1HSF8; -. DR SMR; Q1HSF8; 82-482, 502-655. DR GO; GO:0044174; C:host cell endosome; IEA:UniProtKB-KW. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW. DR Gene3D; 2.170.40.20; -; 2. DR InterPro; IPR000777; HIV1_GP160. DR InterPro; IPR000328; Retroviral_envelope_protein. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; SSF56502; 2. PE 4: Predicted; KW Apoptosis {ECO:0000256|SAAS:SAAS00491382}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00487956}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|SAAS:SAAS00487637}; KW Host cell membrane {ECO:0000256|SAAS:SAAS00491210}; KW Host endosome {ECO:0000256|SAAS:SAAS00491443}; KW Host membrane {ECO:0000256|SAAS:SAAS00493156}; KW Host-virus interaction {ECO:0000256|RuleBase:RU003294, KW ECO:0000256|SAAS:SAAS00490508}; KW Membrane {ECO:0000256|SAAS:SAAS00491184, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAAS:SAAS00491847, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00490549, KW ECO:0000256|SAM:Phobius}; KW Viral attachment to host cell {ECO:0000256|SAAS:SAAS00490424}; KW Viral envelope protein {ECO:0000256|RuleBase:RU003294, KW ECO:0000256|SAAS:SAAS00490691, ECO:0000313|EMBL:ABE03508.1}; KW Viral penetration into host cytoplasm {ECO:0000256|SAAS:SAAS00486890}; KW Virion {ECO:0000256|SAAS:SAAS00491099}; KW Virus entry into host cell {ECO:0000256|SAAS:SAAS00490724}. FT TRANSMEM 668 695 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 33 501 GP120. {ECO:0000259|Pfam:PF00516}. FT DOMAIN 520 709 GP41. {ECO:0000259|Pfam:PF00517}. SQ SEQUENCE 846 AA; 95846 MW; E40EFAB2B740C443 CRC64; MTVMGIRKNY QHCGGWGALF LGVLLICSAA EQLWVTVYYG VPVWKEANTT LFCASDAKGY ETEKHNVWAT HACVPTDPSP QELVLANVTE NFNMWKNNMV EQMHEDIISL WDQSLKPCVK LTPLCVTLTC KNVTNTNGTK TNNSSEKTMR EEMKNCSFNI TTNIRDRIQK QYALFYKLDI VQIDENDNTS YRLISCNTSI ITQACPKVSF EPIPIHYCAP AGFAILKCNN ETFNGTGPCK NVSTVQCTHG IRPVVSTQLL LNGSLAKGEV IIRSANFSDN AKTIIVQLNE SVIINCTRPN NNTRKSIPIG PGRAFYATGD IIGDIRQAHC NVSRKQWNNT LKWVTAKLRE QFNKTIVFKN SSGGDPEIVM HSFNCGGEFF YCNTTPLFNN DTNNETEDNN NTITLQCRIK QIINMWQEVG KAMYAPPISG NISCSSNITG LLLTRDGGHN VSDMTETFRP GGGDMKDNWR SELYKYKVVR IEPLGIAPTK AKRRVVQREK RAVGLGAVFI GFLGAAGSTM GAASMTLTVQ ARQLLSGIVQ QQNNLLRAIE AQQHLLQLTV WGIKQLQARI LAVERYLKDQ QLLGIWGCSG KLICPTTVPW NNSWSNKSMK VIWENMTWMQ WEREIENYTG VIYSLIEESQ NQQERNEQEL LELDKWASLW NWFDITNWLW YIRLFIMIVG GLVGLRIIFV VLSIVNRVRQ GYSPLSFQIR PPAPRGPDRP EGIEEEGGER DRDTSGPLVN GFLEIIWVDL RSLCLFSYRH LRDLLLIAAR IVEILGRRGW EALKYWWNLL QYWSQELKNS AVSLLNAIAI AVAEGTDRIL EILQRAFRAI LHIPTRIRQG LERALL //