ID Q1HSF8_9HIV1 Unreviewed; 846 AA. AC Q1HSF8; DT 13-JUN-2006, integrated into UniProtKB/TrEMBL. DT 13-JUN-2006, sequence version 1. DT 02-NOV-2010, entry version 40. DE RecName: Full=Envelope glycoprotein gp160; GN Name=env; OS Human immunodeficiency virus 1. OC Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; OC Lentivirus; Primate lentivirus group. OX NCBI_TaxID=11676; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C61v1e3; RX PubMed=16641269; DOI=10.1128/JVI.80.10.4758-4770.2006; RA Bailey J.R., Lassen K.G., Yang H.C., Quinn T.C., Ray S.C., RA Blankson J.N., Siliciano R.F.; RT "Neutralizing antibodies do not mediate suppression of human RT immunodeficiency virus type 1 in elite suppressors or selection of RT plasma virus variants in patients on highly active antiretroviral RT therapy."; RL J. Virol. 80:4758-4770(2006). CC -!- FUNCTION: The envelope glyprotein gp160 precursor down-modulates CC cell surface CD4 antigen by interacting with it in the endoplasmic CC reticulum and blocking its transport to the cell surface (By CC similarity). CC -!- FUNCTION: The gp120-gp41 heterodimer allows rapid transcytosis of CC the virus through CD4 negative cells such as simple epithelial CC monolayers of the intestinal, rectal and endocervical epithelial CC barriers. Both gp120 and gp41 specifically recognize CC glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo- CC galactosyl-ceramide (GalS) present in the lipid rafts structures CC of epithelial cells. Binding to these alternative receptors allows CC the rapid transcytosis of the virus through the epithelial cells. CC This transcytotic vesicle-mediated transport of virions from the CC apical side to the basolateral side of the epithelial cells does CC not involve infection of the cells themselves (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ410516; ABE03508.1; -; Genomic_RNA. DR ProteinModelPortal; Q1HSF8; -. DR SMR; Q1HSF8; 82-482, 502-655. DR GO; GO:0044174; C:host cell endosome; IEA:UniProtKB-KW. DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW. DR GO; GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW. DR InterPro; IPR000777; GP120. DR InterPro; IPR000328; Retroviral_envelope_protein. DR Gene3D; G3DSA:2.170.40.20; GP120; 2. DR Pfam; PF00516; GP120; 1. DR Pfam; PF00517; GP41; 1. DR SUPFAM; SSF56502; GP120; 1. PE 3: Inferred from homology; KW AIDS; Apoptosis; Cell membrane; Cleavage on pair of basic residues; KW Envelope protein; Fusion protein; Host cell membrane; Host endosome; KW Host membrane; Host-virus interaction; Membrane; Transmembrane; KW Transmembrane helix; Viral immunoevasion; Virion. SQ SEQUENCE 846 AA; 95846 MW; E40EFAB2B740C443 CRC64; MTVMGIRKNY QHCGGWGALF LGVLLICSAA EQLWVTVYYG VPVWKEANTT LFCASDAKGY ETEKHNVWAT HACVPTDPSP QELVLANVTE NFNMWKNNMV EQMHEDIISL WDQSLKPCVK LTPLCVTLTC KNVTNTNGTK TNNSSEKTMR EEMKNCSFNI TTNIRDRIQK QYALFYKLDI VQIDENDNTS YRLISCNTSI ITQACPKVSF EPIPIHYCAP AGFAILKCNN ETFNGTGPCK NVSTVQCTHG IRPVVSTQLL LNGSLAKGEV IIRSANFSDN AKTIIVQLNE SVIINCTRPN NNTRKSIPIG PGRAFYATGD IIGDIRQAHC NVSRKQWNNT LKWVTAKLRE QFNKTIVFKN SSGGDPEIVM HSFNCGGEFF YCNTTPLFNN DTNNETEDNN NTITLQCRIK QIINMWQEVG KAMYAPPISG NISCSSNITG LLLTRDGGHN VSDMTETFRP GGGDMKDNWR SELYKYKVVR IEPLGIAPTK AKRRVVQREK RAVGLGAVFI GFLGAAGSTM GAASMTLTVQ ARQLLSGIVQ QQNNLLRAIE AQQHLLQLTV WGIKQLQARI LAVERYLKDQ QLLGIWGCSG KLICPTTVPW NNSWSNKSMK VIWENMTWMQ WEREIENYTG VIYSLIEESQ NQQERNEQEL LELDKWASLW NWFDITNWLW YIRLFIMIVG GLVGLRIIFV VLSIVNRVRQ GYSPLSFQIR PPAPRGPDRP EGIEEEGGER DRDTSGPLVN GFLEIIWVDL RSLCLFSYRH LRDLLLIAAR IVEILGRRGW EALKYWWNLL QYWSQELKNS AVSLLNAIAI AVAEGTDRIL EILQRAFRAI LHIPTRIRQG LERALL //