ID   Q1HSF8_9HIV1            Unreviewed;       846 AA.
AC   Q1HSF8;
DT   13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2006, sequence version 1.
DT   02-MAR-2010, entry version 35.
DE   RecName: Full=Envelope glycoprotein gp160;
GN   Name=env;
OS   Human immunodeficiency virus 1.
OC   Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae;
OC   Lentivirus; Primate lentivirus group.
OX   NCBI_TaxID=11676;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C61v1e3;
RX   PubMed=16641269; DOI=10.1128/JVI.80.10.4758-4770.2006;
RA   Bailey J.R., Lassen K.G., Yang H.C., Quinn T.C., Ray S.C.,
RA   Blankson J.N., Siliciano R.F.;
RT   "Neutralizing antibodies do not mediate suppression of human
RT   immunodeficiency virus type 1 in elite suppressors or selection of
RT   plasma virus variants in patients on highly active antiretroviral
RT   therapy.";
RL   J. Virol. 80:4758-4770(2006).
CC   -!- FUNCTION: The envelope glyprotein gp160 precursor down-modulates
CC       cell surface CD4 antigen by interacting with it in the endoplasmic
CC       reticulum and blocking its transport to the cell surface (By
CC       similarity).
CC   -!- FUNCTION: The gp120-gp41 heterodimer allows rapid transcytosis of
CC       the virus through CD4 negative cells such as simple epithelial
CC       monolayers of the intestinal, rectal and endocervical epithelial
CC       barriers. Both gp120 and gp41 specifically recognize
CC       glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-
CC       galactosyl-ceramide (GalS) present in the lipid rafts structures
CC       of epithelial cells. Binding to these alternative receptors allows
CC       the rapid transcytosis of the virus through the epithelial cells.
CC       This transcytotic vesicle-mediated transport of virions from the
CC       apical side to the basolateral side of the epithelial cells does
CC       not involve infection of the cells themselves (By similarity).
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DR   EMBL; DQ410516; ABE03508.1; -; Genomic_RNA.
DR   SMR; Q1HSF8; 82-482, 502-531, 530-655.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR000777; GP120.
DR   InterPro; IPR000328; Retroviral_envelope_protein.
DR   Gene3D; G3DSA:2.170.40.20; GP120; 1.
DR   Pfam; PF00516; GP120; 1.
DR   Pfam; PF00517; GP41; 1.
DR   SUPFAM; SSF56502; GP120; 1.
PE   3: Inferred from homology;
KW   AIDS; Apoptosis; Cell membrane; Cleavage on pair of basic residues;
KW   Envelope protein; Fusion protein; Host cell membrane; Host endosome;
KW   Host membrane; Host-virus interaction; Membrane; Transmembrane;
KW   Viral immunoevasion; Virion.
SQ   SEQUENCE   846 AA;  95846 MW;  E40EFAB2B740C443 CRC64;
     MTVMGIRKNY QHCGGWGALF LGVLLICSAA EQLWVTVYYG VPVWKEANTT LFCASDAKGY
     ETEKHNVWAT HACVPTDPSP QELVLANVTE NFNMWKNNMV EQMHEDIISL WDQSLKPCVK
     LTPLCVTLTC KNVTNTNGTK TNNSSEKTMR EEMKNCSFNI TTNIRDRIQK QYALFYKLDI
     VQIDENDNTS YRLISCNTSI ITQACPKVSF EPIPIHYCAP AGFAILKCNN ETFNGTGPCK
     NVSTVQCTHG IRPVVSTQLL LNGSLAKGEV IIRSANFSDN AKTIIVQLNE SVIINCTRPN
     NNTRKSIPIG PGRAFYATGD IIGDIRQAHC NVSRKQWNNT LKWVTAKLRE QFNKTIVFKN
     SSGGDPEIVM HSFNCGGEFF YCNTTPLFNN DTNNETEDNN NTITLQCRIK QIINMWQEVG
     KAMYAPPISG NISCSSNITG LLLTRDGGHN VSDMTETFRP GGGDMKDNWR SELYKYKVVR
     IEPLGIAPTK AKRRVVQREK RAVGLGAVFI GFLGAAGSTM GAASMTLTVQ ARQLLSGIVQ
     QQNNLLRAIE AQQHLLQLTV WGIKQLQARI LAVERYLKDQ QLLGIWGCSG KLICPTTVPW
     NNSWSNKSMK VIWENMTWMQ WEREIENYTG VIYSLIEESQ NQQERNEQEL LELDKWASLW
     NWFDITNWLW YIRLFIMIVG GLVGLRIIFV VLSIVNRVRQ GYSPLSFQIR PPAPRGPDRP
     EGIEEEGGER DRDTSGPLVN GFLEIIWVDL RSLCLFSYRH LRDLLLIAAR IVEILGRRGW
     EALKYWWNLL QYWSQELKNS AVSLLNAIAI AVAEGTDRIL EILQRAFRAI LHIPTRIRQG
     LERALL
//