ID Q1HL22_MOUSE Unreviewed; 1219 AA. AC Q1HL22; DT 13-JUN-2006, integrated into UniProtKB/TrEMBL. DT 13-JUN-2006, sequence version 1. DT 27-MAR-2024, entry version 127. DE SubName: Full=SorCS3 {ECO:0000313|EMBL:ABF48507.1}; GN Name=Sorcs3 {ECO:0000313|MGI:MGI:1913923}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABF48507.1}; RN [1] {ECO:0000313|EMBL:ABF48507.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BTBR T+ tf/J {ECO:0000313|EMBL:ABF48507.1}; RX PubMed=16682971; DOI=10.1038/ng1796; RA Clee S.M., Yandell B.S., Schueler K.M., Rabaglia M.E., Richards O.C., RA Raines S.M., Kabara E.A., Klass D.M., Mui E.T.-K., Stapleton D.S., RA Gray-Keller M.P., Young M.B., Stoehr J.P., Lan H., Boronenkov I., RA Raess P.W., Flowers M.T., Attie A.D.; RT "Positional cloning of Sorcs1, a type 2 diabetes quantitative trait RT locus."; RL Nat. Genet. 38:688-693(2006). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS CC subfamily. {ECO:0000256|ARBA:ARBA00010818}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ479928; ABF48507.1; -; Genomic_DNA. DR RefSeq; NP_079972.1; NM_025696.3. DR AlphaFoldDB; Q1HL22; -. DR SMR; Q1HL22; -. DR Antibodypedia; 31628; 67 antibodies from 15 providers. DR DNASU; 66673; -. DR GeneID; 66673; -. DR KEGG; mmu:66673; -. DR AGR; MGI:1913923; -. DR CTD; 22986; -. DR MGI; MGI:1913923; Sorcs3. DR VEuPathDB; HostDB:ENSMUSG00000063434; -. DR HOGENOM; CLU_010702_0_0_1; -. DR OMA; RRNDGNC; -. DR OrthoDB; 5840at2759; -. DR PhylomeDB; Q1HL22; -. DR BioGRID-ORCS; 66673; 4 hits in 77 CRISPR screens. DR ChiTaRS; Sorcs3; mouse. DR ExpressionAtlas; Q1HL22; baseline and differential. DR Genevisible; Q1HL22; MM. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR Gene3D; 2.10.70.80; -; 1. DR Gene3D; 3.30.60.270; -; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR000601; PKD_dom. DR InterPro; IPR035986; PKD_dom_sf. DR InterPro; IPR031777; Sortilin_C. DR InterPro; IPR031778; Sortilin_N. DR InterPro; IPR006581; VPS10. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR PANTHER; PTHR12106; SORTILIN RELATED; 1. DR PANTHER; PTHR12106:SF10; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS3; 1. DR Pfam; PF00801; PKD; 1. DR Pfam; PF15902; Sortilin-Vps10; 1. DR Pfam; PF15901; Sortilin_C; 1. DR SMART; SM00602; VPS10; 1. DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1. DR SUPFAM; SSF49299; PKD domain; 2. DR PROSITE; PS50093; PKD; 1. PE 1: Evidence at protein level; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..33 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 34..1219 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5009970135" FT TRANSMEM 1123..1141 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 857..901 FT /note="PKD" FT /evidence="ECO:0000259|PROSITE:PS50093" FT REGION 71..181 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 71..90 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 155..170 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1219 AA; 135985 MW; ABB3278A2EFEC7C4 CRC64; MEAAGTERPA GWPGAPLART GLLLLSTWVL AGAEITWGAT GGPGRLVSPA SRPPVLPPLL PRAAENRWPE ELASARRAAA PRRRSRLEPL SQASRGEIRT EAAGMSPEGA RWVPGIPSPS QAGSARRTRR AQPPSPLERG DSWATALADG AKGSRPHTKG SREEVRATRT GGASTEELRL PSTSFALTGD SAHNQAMVHW SGHNSSVILI LTKLYDFNLG SVTESSLWRS VDYGATYEKL NDKVGLKTVL SYLYVNPTNK RKIMLLSDPE MESSVLISSD EGATYQKYRL TFYIQSLLFH PKQEDWVLAY SLDQKLYSSM DFGRRWQLMH ERITPNRFYW SVSGLDKEAD LVHMEVRTAD GYAHYLTCRI QECAETTRSG PFARSIDISS LVVQDEYIFI QVTIGGRASY YVSYRREAFA QIKLPKYSLP KDMHIISTDE NQVFAAVQEW NQNDTYNLYI SDTRGIYFTL AMENIKSSRG LMGNIIIELY EVAGIKGIFL ANKKVDDQVK TYITYNKGRD WRLLQAPDVD LRGSPVHCLL PFCSLHLHLQ LSENPYSSGR ISSKDTAPGL VVATGNIGSE LSYTDIGVFI SSDGGNTWRQ IFDEEYNVWF LDWGGALVAM KHTPLPVRHL WVSFDEGHSW DKYGFTLLPL FVDGALVEAG VETHIMTVFG HFSLRSEWQL VKVDYKSIFS RRCTKEDFET WHLLNQGEPC VMGERKIFKK RKPGAQCALG REYSGSVVSE PCVCADWDFE CDYGYERHGE SQCVPAFWYN PASPSKDCSL GQSYLNSTGY RRIVSNNCTD GLRDKYSAKT QLCPGKAPRG LHVVTTDGRL VAEQGHNATF IILMEEGDLQ RTNIQLDFGD GVAVSYANFS PIEDGIRHVY KSAGIFQVTA YAENNLGSDT AFLFLHVVCP VEHVHLRVPF VAIRNKDVNI SAVVWPSQLG TLTYFWWFGN STKPLITLDS SISFTFLAEG TNTITVQVAA GNALIQDTKE IAVHEYFQSQ LLSFSPNLDY HNPDIPEWRQ DIGNVIKRAL IKVTSVPEDQ ILVAVFPGLP TSAELFILPP KNLTERRKGH EGDLEQIVET LFNALNQNLV QFELKPGVQV IVYVTQLTLA PLVDSSAGHS SSAMLMLLSV VFVGLAVFLI YKFKRKIPWI NIYAQVQHDK EQEMIGSVSQ SENAPKITLS DFTEPEELLD KELDTRVIGS IATIASSEST KEIPNCTSV //