ID Q1E5N1_COCIM Unreviewed; 133 AA. AC Q1E5N1; DT 11-JUL-2006, integrated into UniProtKB/TrEMBL. DT 11-JUL-2006, sequence version 1. DT 14-NOV-2006, entry version 4. DE Histone H2A. GN ORFNames=CIMG_02132; OS Coccidioides immitis RS. OC Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Onygenales; mitosporic Onygenales; Coccidioides. OX NCBI_TaxID=246410; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=RS; RG The Broad Institute Genome Sequencing Platform; RA Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Henn M., RA Ma L.-J., Jaffe D., Butler J., Alvarez P., Gnerre S., Grabherr M., RA Kleber M., Mauceli E., Brockman W., Rounsley S., Young S., LaButti K., RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R., RA Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., RA Alvarado L., Oleary S., Orbach M.J., Galgiani J., Mandel M.A., RA Kellner E.M.; RT "Annotation of the Coccidioides immitis RS Genome."; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core component of nucleosome which plays a central role CC in DNA double strand break (DSB) repair. Nucleosomes wrap and CC compact DNA into chromatin, limiting DNA accessibility to the CC cellular machineries which require DNA as a template. Histones CC thereby play a central role in transcription regulation, DNA CC repair, DNA replication and chromosomal stability. DNA CC accessibility is regulated via a complex set of post-translational CC modifications of histones, also called histone code, and CC nucleosome remodelling (By similarity). CC -!- SUBUNIT: The nucleosome is a histone octamer containing two CC molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 CC heterotetramer and two H2A-H2B heterodimers. The octamer wraps CC approximately 147 bp of DNA (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC -!- SIMILARITY: Belongs to the histone H2A family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH476726; EAS36778.1; -; Genomic_DNA. DR SMR; Q1E5N1; 14-121. DR GO; GO:0000786; C:nucleosome; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:InterPro. DR GO; GO:0007001; P:chromosome organization and biogenesis (sen...; IEA:InterPro. DR GO; GO:0006334; P:nucleosome assembly; IEA:InterPro. DR InterPro; IPR000886; ER_target_S. DR InterPro; IPR009072; Histone-fold. DR InterPro; IPR007125; Histone_core_D. DR InterPro; IPR002119; Histone_H2A. DR Pfam; PF00125; Histone; 1. DR PRINTS; PR00620; HISTONEH2A. DR SMART; SM00414; H2A; 1. DR PROSITE; PS00014; ER_TARGET; UNKNOWN_1. DR PROSITE; PS00046; HISTONE_H2A; UNKNOWN_1. KW Chromosomal protein; DNA-binding; Nuclear protein; Nucleosome core. SQ SEQUENCE 133 AA; 14219 MW; AA0FA27D95C01F8D CRC64; MTGGKSGGKA SGSKSSQSRS SKAGLAFPVG RVHRLLRKGN YAQRVGAGAP VYLAAVLEYL AAEILELAGN AARDNKKTRI IPRHLQLAIR NDEELNKLLG HVTIAQGGVM PYIHQNLLPK KTPKTGKNPS QEL //