ID NACA_COCIM Reviewed; 205 AA. AC Q1DHR3; J3K086; DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot. DT 11-JUL-2006, sequence version 1. DT 11-NOV-2015, entry version 50. DE RecName: Full=Nascent polypeptide-associated complex subunit alpha; DE Short=NAC-alpha; DE AltName: Full=Alpha-NAC; GN Name=EGD2; ORFNames=CIMG_10150; OS Coccidioides immitis (strain RS) (Valley fever fungus). OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Eurotiomycetidae; Onygenales; mitosporic Onygenales; Coccidioides. OX NCBI_TaxID=246410; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RS; RX PubMed=19717792; DOI=10.1101/gr.087551.108; RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., RA Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., RA Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., RA Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N., Orbach M.J., RA Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.; RT "Comparative genomic analyses of the human fungal pathogens RT Coccidioides and their relatives."; RL Genome Res. 19:1722-1731(2009). RN [2] RP GENOME REANNOTATION. RC STRAIN=RS; RX PubMed=20516208; DOI=10.1101/gr.103911.109; RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J., RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., RA Taylor J.W., Rounsley S.D.; RT "Population genomic sequencing of Coccidioides fungi reveals recent RT hybridization and transposon control."; RL Genome Res. 20:938-946(2010). CC -!- FUNCTION: Component of the nascent polypeptide-associated complex CC (NAC), a dynamic component of the ribosomal exit tunnel, CC protecting the emerging polypeptides from interaction with other CC cytoplasmic proteins to ensure appropriate nascent protein CC targeting. The NAC complex also promotes mitochondrial protein CC import by enhancing productive ribosome interactions with the CC outer mitochondrial membrane and blocks the inappropriate CC interaction of ribosomes translating non-secretory nascent CC polypeptides with translocation sites in the membrane of the CC endoplasmic reticulum. EGD2 may also be involved in transcription CC regulation (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Part of the nascent polypeptide-associated complex (NAC), CC consisting of EGD2 and EGD1. NAC associates with ribosomes via CC EGD1 (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus CC {ECO:0000250}. Note=Predominantly cytoplasmic, may also CC transiently localize to the nucleus. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the NAC-alpha family. {ECO:0000305}. CC -!- SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain. CC {ECO:0000255|PROSITE-ProRule:PRU00507}. CC -!- SIMILARITY: Contains 1 UBA domain. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GG704915; EAS27545.3; -; Genomic_DNA. DR RefSeq; XP_001239128.1; XM_001239127.2. DR STRING; 246410.XP_001239128.1; -. DR GeneID; 4558192; -. DR KEGG; cim:CIMG_10150; -. DR EuPathDB; FungiDB:CIMG_10150; -. DR eggNOG; KOG2239; Eukaryota. DR eggNOG; COG1308; LUCA. DR InParanoid; Q1DHR3; -. DR KO; K03626; -. DR OrthoDB; EOG7ZD27F; -. DR Proteomes; UP000001261; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR InterPro; IPR016641; EGD2/NACA. DR InterPro; IPR002715; Nas_poly-pep-assoc_cplx_dom. DR PANTHER; PTHR21713; PTHR21713; 1. DR Pfam; PF01849; NAC; 1. DR PIRSF; PIRSF015901; NAC_alpha; 1. DR PROSITE; PS51151; NAC_AB; 1. PE 3: Inferred from homology; KW Complete proteome; Cytoplasm; Nucleus; Protein transport; KW Reference proteome; Transport. FT CHAIN 1 205 Nascent polypeptide-associated complex FT subunit alpha. FT /FTId=PRO_0000273486. FT DOMAIN 48 113 NAC-A/B. {ECO:0000255|PROSITE- FT ProRule:PRU00507}. FT DOMAIN 166 205 UBA. SQ SEQUENCE 205 AA; 22081 MW; 05F26F97F7F05DD4 CRC64; MANPRVEELP DEEVPKTTVE DAGESSESEA EAAEEPTIPG GAAITVHSRN EKKARKAIGK LGLKHVPGIT RVTLRRPKNI LFVINQPDVY RSPSSNTWII FGEAKIEDLN SQAQASAAQQ LSAAEAAGNG EHAGHEHIDL GKGKAPETEK KEEEEEEEGE VDETGLEAKD IELVMAQANV SRSKAIKALK ENDNDIVNSI MALSV //