ID NACA_COCIM Reviewed; 205 AA. AC Q1DHR3; DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot. DT 11-JUL-2006, sequence version 1. DT 23-JAN-2007, entry version 4. DE Nascent polypeptide-associated complex subunit alpha (NAC-alpha) DE (Alpha-NAC). GN Name=EGD2; ORFNames=CIMG_10150; OS Coccidioides immitis. OC Eukaryota; Fungi; Ascomycota; Pezizomycotina; Eurotiomycetes; OC Onygenales; mitosporic Onygenales; Coccidioides. OX NCBI_TaxID=5501; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RS; RA Birren B.W., Lander E.S., Galagan J.E., Devon K., Nusbaum C., Henn M., RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., RA LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., RA Engels R., Montgomery P., Pearson M., Howarth C., Kodira C.D., RA Zeng Q., Yandava C., Alvarado L., Oleary S., Orbach M.J., Galgiani J., RA Mandel M.A., Kellner E.M.; RT "Annotation of the Coccidioides immitis RS genome."; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the nascent polypeptide-associated complex CC (NAC), a dynamic component of the ribosomal exit tunnel, CC protecting the emerging polypeptides from interaction with other CC cytoplasmic proteins to ensure appropriate nascent protein CC targeting (By similarity). The NAC complex also promotes CC mitochondrial protein import by enhancing productive ribosome CC interactions with the outer mitochondrial membrane and blocks the CC inappropriate interaction of ribosomes translating non-secretory CC nascent polypeptides with translocation sites in the membrane of CC the endoplasmic reticulum (By similarity). EGD2 is also involved CC in transcription regulation (By similarity). CC -!- SUBUNIT: Part of the nascent polypeptide-associated complex (NAC), CC consisting of EGD2 and EGD1. NAC associates with ribosomes via CC EGD1 (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By CC similarity). Note=Predominantly cytoplasmic, may also transiently CC localize to the nucleus (By similarity). CC -!- SIMILARITY: Belongs to the NAC-alpha family. CC -!- SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain. CC -!- SIMILARITY: Contains 1 UBA domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH476731; EAS27545.1; -; Genomic_DNA. DR InterPro; IPR002715; NAC. DR Pfam; PF01849; NAC; 1. DR PROSITE; PS51151; NAC_AB; 1. DR PROSITE; PS50030; UBA; FALSE_NEG. KW Nuclear protein; Protein transport; Transcription; KW Transcription regulation; Transport. FT CHAIN 1 205 Nascent polypeptide-associated complex FT subunit alpha. FT /FTId=PRO_0000273486. FT DOMAIN 48 113 NAC-A/B. FT DOMAIN 166 205 UBA. SQ SEQUENCE 205 AA; 22081 MW; 05F26F97F7F05DD4 CRC64; MANPRVEELP DEEVPKTTVE DAGESSESEA EAAEEPTIPG GAAITVHSRN EKKARKAIGK LGLKHVPGIT RVTLRRPKNI LFVINQPDVY RSPSSNTWII FGEAKIEDLN SQAQASAAQQ LSAAEAAGNG EHAGHEHIDL GKGKAPETEK KEEEEEEEGE VDETGLEAKD IELVMAQANV SRSKAIKALK ENDNDIVNSI MALSV //