ID WRN_CAEEL STANDARD; PRT; 1056 AA. AC Q19546; DT 10-OCT-2003 (Rel. 42, Created) DT 10-OCT-2003 (Rel. 42, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Probable Werner syndrome helicase homolog 1. GN Name=wrn-1; ORFNames=F18C5.2; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=Bristol N2; RA Fulton L.; RL Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases. RN [2] RP REVISIONS. RA Waterston R.; RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases. RN [3] RP REPEATS. RX MEDLINE=99160561; PubMed=10049920; RA Kusano K., Berres M.E., Engels W.R.; RT "Evolution of the RECQ family of helicases: a Drosophila homolog, RT Dmblm, is similar to the human Bloom syndrome gene."; RL Genetics 151:1027-1039(1999). CC -!- FUNCTION: Essential for the formation of DNA replication focal CC centers; stably associates with foci elements generating binding CC sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA- CC helicase activity. May be involved in the control of genomic CC stability (By similarity). CC -!- SUBCELLULAR LOCATION: Nuclear (By similarity). CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily. CC -!- SIMILARITY: Contains 1 HRDC domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U29097; AAA68410.2; -. DR PIR; T16087; T16087. DR WormPep; F18C5.2; CE31791. DR InterPro; IPR001410; DEAD. DR InterPro; IPR002464; DEAH_box. DR InterPro; IPR001650; Helicase_C. DR InterPro; IPR002121; HRDC. DR InterPro; IPR004589; RecQ. DR Pfam; PF00270; DEAD; 1. DR Pfam; PF00271; Helicase_C; 1. DR Pfam; PF00570; HRDC; 1. DR TIGRFAMs; TIGR00614; recQ_fam; 1. DR PROSITE; PS00690; DEAH_ATP_HELICASE; FALSE_NEG. DR PROSITE; PS50967; HRDC; 1. KW ATP-binding; DNA-binding; Helicase; Hydrolase; Hypothetical protein; KW Nuclear protein; Repeat. FT DOMAIN 17 37 2 X 10 AA repeats of N-[ED]-E-L-P-E-T-E- FT P-E. FT REPEAT 17 26 1. FT REPEAT 28 37 2. FT DOMAIN 4 7 Poly-Asp. FT DOMAIN 90 95 Poly-Ser. FT DOMAIN 628 631 Poly-Ser. FT DOMAIN 806 886 HRDC. FT NP_BIND 249 256 ATP (By similarity). FT SITE 348 351 DEAH box. SQ SEQUENCE 1056 AA; 118522 MW; 99C23E70D06DAA0B CRC64; MISDDDDLPS TRPGSVNEEL PETEPEDNDE LPETEPESDS DKPTVTSNKT ENQVADEDYD SFDDFVPSQT HTASKIPVKN KRAKKCTVES DSSSSDDSDQ GDDCEFIPAC DETQEVPKIK RGYTLRTRAS VKNKCDDSWD DGIDEEDVSK RSEDTLNDSF VDPEFMDSVL DNQLTIKGKK QFLDDGEFFT DRNVPQIDEA TKMKWASMTS PPQEALNALN EFFGHKGFRE KQWDVVRNVL GGKDQFVLMS TGYGKSVCYQ LPSLLLNSMT VVVSPLISLM NDQVTTLVSK GIDAVKLDGH STQIEWDQVA NNMHRIRFIY MSPEMVTSQK GLELLTSCRK HISLLAIDEA HCVSQWGHDF RNSYRHLAEI RNRSDLCNIP MIALTATATV RVRDDVIANL RLRKPLITTT SFDRKNLYIS VHSSKDMAED LGLFMKTDEV KGRHFGGPTI IYCQTKQMVD DVNCVLRRIG VRSAHYHAGL TKNQREKAHT DFMRDKITTI VATVAFGMGI DKPDVRNVIH YGCPNNIESY YQEIGRAGRD GSPSICRVFW APKDLNTIKF KLRNSQQKEE VVENLTMMLR QLELVLTTVG CRRYQLLKHF DPSYAKPPTM QADCCDRCTE MLNGNQDSSS SIVDVTTESK WLFQVINEMY NGKTGIGKPI EFLRGSSKED WRIKTTSQQK LFGIGKHIPD KWWKALAASL RIAGYLGEVR LMQMKFGSCI TLSELGERWL LTGKEMKIDA TPILLQGKKE KAAPSTVPGA SRSQSTKSST EIPTKILGAN KIREYEPANE NEQLMNLKKQ EVTGLPEKID QLRSRLDDIR VGIANMHEVA PFQIVSNTVL DCFANLRPTS ASNLEMIDGM SAQQKSRYGK RFVDCVVQFS KETGIATNVN ANDMIPPELI SKMQKVLSDA VRRVYTEHLI SRSTAKEVAT ARGISEGTVY SYLAMAVEKG LPLHLDKLNV SRKNIAMALN AVRVHLGSNV AVLTPWVEAM GVVPDFNQLK LIRAILIYEY GLDTSENQEK PDIQSMPSTS NPSTIKTVPS TPSSSLRAPP LKKFKL //