ID GPA17_CAEEL Reviewed; 356 AA. AC Q18434; C3U544; Q867E1; Q867N8; Q868B7; Q86FY4; Q86FY5; DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 23-MAR-2010, entry version 62. DE RecName: Full=Guanine nucleotide-binding protein alpha-17 subunit; DE AltName: Full=Odorant response abnormal protein 3; GN Name=odr-3; ORFNames=C34D1.3; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION RP PHENOTYPE, AND MUTAGENESIS OF SER-47 AND GLN-206. RX PubMed=9459442; DOI=10.1016/S0896-6273(00)80434-1; RA Roayaie K., Crump J.G., Sagasti A., Bargmann C.I.; RT "The G alpha protein ODR-3 mediates olfactory and nociceptive function RT and controls cilium morphogenesis in C. elegans olfactory neurons."; RL Neuron 20:55-67(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Bristol N2; RX PubMed=18629017; DOI=10.1002/cfg.318; RA Cuppen E., van der Linden A.M., Jansen G., Plasterk R.H.; RT "Proteins Interacting With Caenorhabditis elegans Galpha Subunits."; RL Comp. Funct. Genomics 4:479-491(2003). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=PX174, PX178, and PX179; RX PubMed=19001295; DOI=10.1534/genetics.107.082651; RA Jovelin R., Dunham J.P., Sung F.S., Phillips P.C.; RT "High nucleotide divergence in developmental regulatory genes RT contrasts with the structural elements of olfactory pathways in RT caenorhabditis."; RL Genetics 181:1387-1397(2009). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-350, FUNCTION, AND DISRUPTION RP PHENOTYPE. RC STRAIN=AB3, BO, CB4855, CB4856, CB4857, CB4932, DH424, RC301, and RC TR403; RX MEDLINE=22582093; PubMed=12694294; RX DOI=10.1046/j.1365-294X.2003.01805.x; RA Jovelin R., Ajie B.C., Phillips P.C.; RT "Molecular evolution and quantitative variation for chemosensory RT behaviour in the nematode genus Caenorhabditis."; RL Mol. Ecol. 12:1325-1337(2003). RN [6] RP GENE FAMILY, NOMENCLATURE, AND FUNCTION. RX PubMed=10192394; DOI=10.1038/7753; RA Jansen G., Thijssen K.L., Werner P., van der Horst M., Hazendonk E., RA Plasterk R.H.A.; RT "The complete family of genes encoding G proteins of Caenorhabditis RT elegans."; RL Nat. Genet. 21:414-419(1999). RN [7] RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION RP PHENOTYPE. RX PubMed=15342507; DOI=10.1534/genetics.103.024786; RA Lans H., Rademakers S., Jansen G.; RT "A network of stimulatory and inhibitory Galpha-subunits regulates RT olfaction in Caenorhabditis elegans."; RL Genetics 167:1677-1687(2004). CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are CC involved as modulators or transducers in various transmembrane CC signaling systems. This specific G-alpha subunit plays an CC important role in olfaction and in cilia morphogenesis. Involved CC in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5- CC trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and CC 2,3-pentanedione. Displays a redundant function with gpa-3 in CC chemotactic responses. Involved in avoidance responses to copper, CC sodium dodecyl sulfate and linoleic acid. Involved in osmotic CC avoidance and mechanosensory responses. Involved in specifying CC fan-like morphology of cilia of head sensory neurons AWC. CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and CC gamma. The alpha chain contains the guanine nucleotide binding CC site (By similarity). CC -!- SUBCELLULAR LOCATION: Cell projection, cilium. Cell projection, CC dendrite. Note=In amphid neurons also weakly expressed in cell CC body. In phasmid neurons found only in cilia. CC -!- TISSUE SPECIFICITY: Expressed in sensory neurons in the head and CC tail. Expressed in amphid AWC neurons, to a lesser extent in AWB CC and weakly in AWA, ASH and ADF neurons (head sensory neurons). CC Expressed in phasmid PHA and PHB neurons (tail sensory neurons). CC -!- DISRUPTION PHENOTYPE: Defective in chemotactic responses to CC attractants and repellants and in osmotic and mechanosensory CC avoidance. CC -!- SIMILARITY: Belongs to the G-alpha family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY008142; AAG32095.1; -; mRNA. DR EMBL; FJ455729; ACQ43989.1; -; Genomic_DNA. DR EMBL; FJ455730; ACQ43990.1; -; Genomic_DNA. DR EMBL; FJ455731; ACQ43991.1; -; Genomic_DNA. DR EMBL; Z78060; CAB01489.1; -; Genomic_DNA. DR EMBL; AY146558; AAN78230.1; -; Genomic_DNA. DR EMBL; AY146559; AAN78231.1; -; Genomic_DNA. DR EMBL; AY146560; AAN78232.1; -; Genomic_DNA. DR EMBL; AY146561; AAN78233.1; -; Genomic_DNA. DR EMBL; AY146562; AAN78234.1; -; Genomic_DNA. DR EMBL; AY146563; AAN78235.1; -; Genomic_DNA. DR EMBL; AY146564; AAN78236.1; -; Genomic_DNA. DR EMBL; AY146565; AAN78237.1; -; Genomic_DNA. DR EMBL; AY146566; AAN78238.1; -; Genomic_DNA. DR PIR; T19715; T19715. DR RefSeq; NP_506290.1; -. DR UniGene; Cel.2932; -. DR SMR; Q18434; 11-356. DR STRING; Q18434; -. DR Ensembl; C34D1.3; C34D1.3; C34D1.3; Caenorhabditis elegans. DR GeneID; 179806; -. DR KEGG; cel:C34D1.3; -. DR NMPDR; fig|6239.3.peg.20234; -. DR UCSC; C34D1.3; c. elegans. DR CTD; 179806; -. DR WormBase; WBGene00003850; odr-3. DR WormPep; C34D1.3; CE08571. DR eggNOG; KOG0082; -. DR HOGENOM; HBG444960; -. DR InParanoid; Q18434; -. DR OMA; EMRSEYQ; -. DR PhylomeDB; Q18434; -. DR NextBio; 906938; -. DR ArrayExpress; Q18434; -. DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell. DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell. DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW. DR GO; GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:InterPro. DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW. DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW. DR InterPro; IPR001408; Gprotein_alpha_I. DR InterPro; IPR001019; Gprotein_alpha_su. DR InterPro; IPR011025; GproteinA_insert. DR PANTHER; PTHR10218; Gprotein_alph_bd; 1. DR Pfam; PF00503; G-alpha; 1. DR PRINTS; PR00318; GPROTEINA. DR PRINTS; PR00441; GPROTEINAI. DR SMART; SM00275; G_alpha; 1. DR SUPFAM; SSF47895; Transducn_insert; 1. PE 1: Evidence at protein level; KW Cell projection; Chemotaxis; Cilium; Complete proteome; GTP-binding; KW Lipoprotein; Myristate; Nucleotide-binding; Olfaction; Palmitate; KW Sensory transduction; Transducer. FT INIT_MET 1 1 Removed (Potential). FT CHAIN 2 356 Guanine nucleotide-binding protein alpha- FT 17 subunit. FT /FTId=PRO_0000203659. FT NP_BIND 40 47 GTP (By similarity). FT NP_BIND 202 206 GTP (By similarity). FT NP_BIND 271 274 GTP (By similarity). FT LIPID 2 2 N-myristoyl glycine (Potential). FT LIPID 4 4 S-palmitoyl cysteine (Potential). FT MUTAGEN 47 47 S->C: Loss of chemotactic responses. FT MUTAGEN 206 206 Q->L: Loss of chemotactic and osmotic FT avoidance responses. SQ SEQUENCE 356 AA; 40434 MW; CB9F36F5F4FB95D9 CRC64; MGSCQSNENS EGNARNKEIE KQLNADKRAG SSIVKLLLLG AGECGKSTVL KQMQILHSNG FTEEEVNEKR AIVYNNTVSA MCTILRAMDG VLHLPLENGQ KEAEKAIVMK VQENGEEGEA LTEEVSKAIQ SLWADPGVKK AFEMRSEYQL PDSAKYFLDN CQRISEPGYR PNDQDILYSR VATTGVVEVK FKIKELDFRV FDVGGQRSER RKWIHCFDNV ESIIFITAIS EYDQVLFEDE TTNRMIESMQ LFNSICNSTW FLSTAMILFM NKKDLFMEKI QRVNITTAFP DYEGGQNYEE AVSFIKQKFA ELNLNPDKKT IYMHETCATD TNQVQLVISS VIDTIIQKNL QKAGMM //