ID GPA17_CAEEL STANDARD; PRT; 356 AA. AC Q18434; Q86FY4; DT 24-JAN-2006 (Rel. 49, Created) DT 24-JAN-2006 (Rel. 49, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Guanine nucleotide-binding protein alpha-17 subunit (Odorant response DE abnormal protein 3). GN Name=odr-3; ORFNames=C34D1.3; OS Caenorhabditis elegans. OC Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; OC Rhabditidae; Peloderinae; Caenorhabditis. OX NCBI_TaxID=6239; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Bristol N2; RA Cuppen E., Jansen G., Plasterk R.H.A.; RT "Interaction analysis of the complete G-alpha subfamily of RT heterotrimeric G proteins from Caenorhabditis elegans."; RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Bristol N2; RX MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012; RG The C. elegans sequencing consortium; RT "Genome sequence of the nematode C. elegans: a platform for RT investigating biology."; RL Science 282:2012-2018(1998). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-350, AND FUNCTION. RC STRAIN=AB3; RX MEDLINE=22582093; PubMed=12694294; RX DOI=10.1046/j.1365-294X.2003.01805.x; RA Jovelin R., Ajie B.C., Phillips P.C.; RT "Molecular evolution and quantitative variation for chemosensory RT behaviour in the nematode genus Caenorhabditis."; RL Mol. Ecol. 12:1325-1337(2003). RN [4] RP FUNCTION. RX PubMed=15342507; DOI=10.1534/genetics.103.024786; RA Lans H., Rademakers S., Jansen G.; RT "A network of stimulatory and inhibitory Galpha-subunits regulates RT olfaction in Caenorhabditis elegans."; RL Genetics 167:1677-1687(2004). RN [5] RP GENE FAMILY, AND NOMENCLATURE. RX PubMed=10192394; DOI=10.1038/7753; RA Jansen G., Thijssen K.L., Werner P., van der Horst M., Hazendonk E., RA Plasterk R.H.A.; RT "The complete family of genes encoding G proteins of Caenorhabditis RT elegans."; RL Nat. Genet. 21:414-419(1999). CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are CC involved as modulators or transducers in various transmembrane CC signaling systems. This specific G-alpha subunit plays an CC important role in olfaction and in cilia morphogenesis. CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and CC gamma. The alpha chain contains the guanine nucleotide binding CC site. CC -!- SIMILARITY: Belongs to the G-alpha family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY008142; AAG32095.1; -; mRNA. DR EMBL; Z78060; CAB01489.1; -; Genomic_DNA. DR EMBL; AY146566; AAN78238.1; -; Genomic_DNA. DR PIR; T19715; T19715. DR HSSP; P04896; 1CUL. DR Ensembl; C34D1.3; Caenorhabditis elegans. DR WormBase; WBGene00003850; odr-3. DR WormPep; C34D1.3; CE08571. DR InterPro; IPR001019; Gprotein_alph_bd. DR InterPro; IPR001408; Gprotein_alpha_I. DR InterPro; IPR011025; GproteinA_insert. DR Pfam; PF00503; G-alpha; 1. DR PRINTS; PR00318; GPROTEINA. DR PRINTS; PR00441; GPROTEINAI. DR ProDom; PD000281; Gprotein_alpha; 1. DR SMART; SM00275; G_alpha; 1. KW Complete proteome; GTP-binding; Nucleotide-binding; Olfaction; KW Sensory transduction; Transducer. FT NP_BIND 40 47 GTP (By similarity). FT NP_BIND 202 206 GTP (By similarity). FT NP_BIND 271 274 GTP (By similarity). SQ SEQUENCE 356 AA; 40434 MW; CB9F36F5F4FB95D9 CRC64; MGSCQSNENS EGNARNKEIE KQLNADKRAG SSIVKLLLLG AGECGKSTVL KQMQILHSNG FTEEEVNEKR AIVYNNTVSA MCTILRAMDG VLHLPLENGQ KEAEKAIVMK VQENGEEGEA LTEEVSKAIQ SLWADPGVKK AFEMRSEYQL PDSAKYFLDN CQRISEPGYR PNDQDILYSR VATTGVVEVK FKIKELDFRV FDVGGQRSER RKWIHCFDNV ESIIFITAIS EYDQVLFEDE TTNRMIESMQ LFNSICNSTW FLSTAMILFM NKKDLFMEKI QRVNITTAFP DYEGGQNYEE AVSFIKQKFA ELNLNPDKKT IYMHETCATD TNQVQLVISS VIDTIIQKNL QKAGMM //