ID Q17UX2_HBV Unreviewed; 134 AA. AC Q17UX2; DT 25-JUL-2006, integrated into UniProtKB/TrEMBL. DT 25-JUL-2006, sequence version 1. DT 27-MAR-2024, entry version 67. DE SubName: Full=RNA-directed DNA polymerase {ECO:0000313|EMBL:CAK55519.1}; DE EC=2.7.7.49 {ECO:0000313|EMBL:CAK55519.1}; DE Flags: Fragment; GN Name=Pol {ECO:0000313|EMBL:CAK55519.1}; GN Synonyms=RT {ECO:0000313|EMBL:CAK55519.1}; OS Hepatitis B virus subtype ayw. OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; OC Blubervirales; Hepadnaviridae; Orthohepadnavirus; Hepatitis B virus. OX NCBI_TaxID=10418 {ECO:0000313|EMBL:CAK55519.1}; RN [1] {ECO:0000313|EMBL:CAK55519.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=HBV-MM-KWT-13 {ECO:0000313|EMBL:CAK55519.1}; RX PubMed=20509964; RA Ali M.M., Hasan F., Ahmad S., Al-Nakib W.; RT "Comparative evaluation of INNO-LiPA HBV assay, direct DNA sequencing and RT subtractive PCR-RFLP for genotyping of clinical HBV isolates."; RL Virol. J. 7:111-111(2010). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AM279432; CAK55519.1; -; Genomic_DNA. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0075513; P:caveolin-mediated endocytosis of virus by host cell; IEA:UniProtKB-KW. DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW. DR Gene3D; 3.30.70.270; -; 1. DR InterPro; IPR043502; DNA/RNA_pol_sf. DR InterPro; IPR000349; HBV_HBSAG. DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase. DR InterPro; IPR000477; RT_dom. DR Pfam; PF00078; RVT_1; 1. DR Pfam; PF00695; vMSA; 1. DR SUPFAM; SSF56672; DNA/RNA polymerases; 1. DR PROSITE; PS50878; RT_POL; 1. PE 4: Predicted; KW Caveolin-mediated endocytosis of virus by host KW {ECO:0000256|ARBA:ARBA00033788}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Endonuclease {ECO:0000256|ARBA:ARBA00022759}; KW Fusion of virus membrane with host endosomal membrane KW {ECO:0000256|ARBA:ARBA00022510}; KW Fusion of virus membrane with host membrane KW {ECO:0000256|ARBA:ARBA00022510}; Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, KW ECO:0000313|EMBL:CAK55519.1}; KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918, KW ECO:0000313|EMBL:CAK55519.1}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAK55519.1}; KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879}; KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00033788}; KW Virion {ECO:0000256|ARBA:ARBA00022879}; KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890}; KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00033788}. FT DOMAIN 1..133 FT /note="Reverse transcriptase" FT /evidence="ECO:0000259|PROSITE:PS50878" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAK55519.1" FT NON_TER 134 FT /evidence="ECO:0000313|EMBL:CAK55519.1" SQ SEQUENCE 134 AA; 14778 MW; 8A0BDD416DD01AEA CRC64; SSTTSGPCRT CTTPAQGTSM YPSCCCTKPS DGNCTCIPIP SSWAFGKFLW EWASARFSWL SLLVPFVQWF VGLSPTCLAY SYMDDVVLGA KSVQHLESLF TAVTNFLLSL GIHLNPNKTK RWGYSLHFMG YVIG //