ID Q17UX2_HBV Unreviewed; 134 AA. AC Q17UX2; DT 25-JUL-2006, integrated into UniProtKB/TrEMBL. DT 25-JUL-2006, sequence version 1. DT 02-MAR-2010, entry version 22. DE SubName: Full=RNA-directed DNA polymerase; DE EC=2.7.7.49; DE Flags: Fragment; GN Name=Pol/RT; OS Hepatitis B virus subtype ayw. OC Viruses; Retro-transcribing viruses; Hepadnaviridae; OC Orthohepadnavirus. OX NCBI_TaxID=10418; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=HBV-MM-KWT-13; RA Ali M.M., Hasan F.A., Ahmad S., Al-Nakib W.; RT "Evaluation of HBV pol gene functional domains diversity."; RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The large envelope protein exists in two topological CC conformations, one which is termed 'external' or Le-HBsAg and the CC other 'internal' or Li-HBsAg. In its external conformation the CC protein attaches the virus to cell receptors and thereby CC initiating infection. This interaction determines the species CC specificity and liver tropism. It also assume fusion between CC virion membrane and cellular membrane. In its internal CC conformation the protein plays a role in virion morphogenesis and CC mediates the contact with the nucleocapsid like a matrix protein CC (By similarity). CC -!- SIMILARITY: Contains 1 reverse transcriptase domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AM279432; CAK55519.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0006278; P:RNA-dependent DNA replication; IEA:InterPro. DR GO; GO:0016032; P:viral reproduction; IEA:InterPro. DR InterPro; IPR000349; Hepvir_surfAg. DR InterPro; IPR000477; Reverse_transcriptase. DR Pfam; PF00078; RVT_1; 1. DR Pfam; PF00695; vMSA; 1. DR PROSITE; PS50878; RT_POL; 1. PE 3: Inferred from homology; KW Membrane; Nucleotidyltransferase; RNA-directed DNA polymerase; KW Transferase; Transmembrane; Virion. FT NON_TER 1 1 FT NON_TER 134 134 SQ SEQUENCE 134 AA; 14778 MW; 8A0BDD416DD01AEA CRC64; SSTTSGPCRT CTTPAQGTSM YPSCCCTKPS DGNCTCIPIP SSWAFGKFLW EWASARFSWL SLLVPFVQWF VGLSPTCLAY SYMDDVVLGA KSVQHLESLF TAVTNFLLSL GIHLNPNKTK RWGYSLHFMG YVIG //