ID Q16591_HUMAN Unreviewed; 188 AA. AC Q16591; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 08-NOV-2023, entry version 90. DE SubName: Full=MYC proto-oncogene, bHLH transcription factor {ECO:0000313|Ensembl:ENSP00000493145.1}; DE SubName: Full=Myc protein {ECO:0000313|EMBL:AAA59887.1, ECO:0000313|EMBL:AAA88090.1}; DE SubName: Full=ORF 118 {ECO:0000313|EMBL:AAA88094.1}; GN Name=MYC {ECO:0000313|EMBL:AAA88090.1, GN ECO:0000313|Ensembl:ENSP00000493145.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA88090.1}; RN [1] {ECO:0000313|EMBL:CAA25105.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=6324175; DOI=10.1073/pnas.80.24.7476; RA Saito H., Hayday A.C., Wiman K.G., Hayward W.S., Tonegawa S.; RT "Activation of the c-myc gene by translocation: a model for translational RT control."; RL Proc. Natl. Acad. Sci. U.S.A. 80:7476-7480(1983). RN [2] {ECO:0000313|EMBL:CAA25105.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=6714223; RA Gazin C., De Dinechin S.D., Hampe A., Masson J., Martin P., Stehelin D., RA Galibert F.; RT "Nucleotide sequence of the human c-myc locus: provocative open reading RT frame within the first exon."; RL EMBO J. 3:383-387(1984). RN [3] {ECO:0000313|EMBL:AAA88090.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=3778453; DOI=10.1016/0006-291X(86)91092-2; RA Eladari M.E., Syed S.H., Guilhot S., d'Auriol L., Galibert F.; RT "On the high conservation of the human c-myc first exon."; RL Biochem. Biophys. Res. Commun. 140:313-319(1986). RN [4] {ECO:0000313|EMBL:CAA25105.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=2430795; RA Gazin C., Rigolet M., Briand J.P., Van Regenmortel M.H.V., Galibert F.; RT "Immunochemical detection of proteins related to the human c-myc exon 1."; RL EMBO J. 5:2241-2250(1986). RN [5] {ECO:0000313|EMBL:AAA88094.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Promyelocytic leukemia {ECO:0000313|EMBL:AAA88094.1}; RX PubMed=3540591; RA Bentley D.L., Groudine M.; RT "Novel promoter upstream of the human c-myc gene and regulation of c-myc RT expression in B-cell lymphomas."; RL Mol. Cell. Biol. 6:3481-3489(1986). RN [6] {ECO:0000313|EMBL:CAA25105.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=3243428; DOI=10.1016/0378-1119(88)90131-X; RA Guilhot S., Petridou B., Syed-Hussain S., Galibert F.; RT "Nucleotide sequence 3' to the human c-myc oncogene; presence of a long RT inverted repeat."; RL Gene 72:105-108(1988). RN [7] {ECO:0000313|EMBL:AAA59887.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Leukemia {ECO:0000313|EMBL:AAA59887.1}; RX PubMed=2834731; DOI=10.1073/pnas.85.9.3052; RA Finver S.N., Nishikura K., Finger L.R., Haluska F.G., Finan J., RA Nowell P.C., Croce C.M.; RT "Sequence analysis of the MYC oncogene involved in the t(8;14)(q24;q11) RT chromosome translocation in a human leukemia T-cell line indicates that RT putative regulatory regions are not altered."; RL Proc. Natl. Acad. Sci. U.S.A. 85:3052-3056(1988). RN [8] {ECO:0000313|Ensembl:ENSP00000493145.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, RA Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., RA O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K., RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., RA Platzer M., Shimizu N., Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [9] {ECO:0000313|Ensembl:ENSP00000493145.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC103819; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; J03253; AAA59887.1; -; Genomic_DNA. DR EMBL; M14206; AAA88090.1; -; Genomic_DNA. DR EMBL; M13930; AAA88094.1; -; mRNA. DR EMBL; X00364; CAA25105.1; -; Genomic_DNA. DR PIR; A29867; A29867. DR PIR; I79500; I79500. DR Antibodypedia; 3520; 4321 antibodies from 53 providers. DR Ensembl; ENST00000641036.1; ENSP00000493145.1; ENSG00000136997.22. DR HGNC; HGNC:7553; MYC. DR VEuPathDB; HostDB:ENSG00000136997; -. DR GeneTree; ENSGT00940000155285; -. DR ChiTaRS; MYC; human. DR Proteomes; UP000005640; Chromosome 8. DR Bgee; ENSG00000136997; Expressed in upper leg skin and 180 other tissues. DR ExpressionAtlas; Q16591; baseline and differential. PE 2: Evidence at transcript level; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT REGION 1..51 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 102..134 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 37..51 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 109..123 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 188 AA; 20955 MW; 677ADDDAC541477B CRC64; MRGSGRLRTP ELCCSRPPPP GPGRPWLPSC LEKGRASQRL GGKKNGGRDR AEYKSRFSGL YLTRCSNSSE RQRERAGGRL GWKSRASRAA LRASWEGRSG ANRGLRLWPS PPADPPASGP QPLPHPRNFA HSSGRALCTG TYNTRARTRL SRRGEAILPI WGHFPAAART RFSERLSLQL LRRWIFFG //