ID Q16591_HUMAN Unreviewed; 188 AA. AC Q16591; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 18-SEP-2019, entry version 69. DE SubName: Full=Myc protein {ECO:0000313|EMBL:AAA59887.1, ECO:0000313|EMBL:AAA88090.1}; DE SubName: Full=Myc proto-oncogene protein {ECO:0000313|Ensembl:ENSP00000493145}; DE SubName: Full=ORF 118 {ECO:0000313|EMBL:AAA88094.1}; GN Name=MYC {ECO:0000313|EMBL:AAA88090.1, GN ECO:0000313|Ensembl:ENSP00000493145}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA88090.1}; RN [1] {ECO:0000313|EMBL:CAA25105.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=6324175; DOI=10.1073/pnas.80.24.7476; RA Saito H., Hayday A.C., Wiman K.G., Hayward W.S., Tonegawa S.; RT "Activation of the c-myc gene by translocation: a model for RT translational control."; RL Proc. Natl. Acad. Sci. U.S.A. 80:7476-7480(1983). RN [2] {ECO:0000313|EMBL:CAA25105.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=6714223; RA Gazin C., De Dinechin S.D., Hampe A., Masson J., Martin P., RA Stehelin D., Galibert F.; RT "Nucleotide sequence of the human c-myc locus: provocative open RT reading frame within the first exon."; RL EMBO J. 3:383-387(1984). RN [3] {ECO:0000313|EMBL:AAA88090.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=3778453; DOI=10.1016/0006-291X(86)91092-2; RA Eladari M.E., Syed S.H., Guilhot S., d'Auriol L., Galibert F.; RT "On the high conservation of the human c-myc first exon."; RL Biochem. Biophys. Res. Commun. 140:313-319(1986). RN [4] {ECO:0000313|EMBL:CAA25105.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=2430795; RA Gazin C., Rigolet M., Briand J.P., Van Regenmortel M.H.V., RA Galibert F.; RT "Immunochemical detection of proteins related to the human c-myc exon RT 1."; RL EMBO J. 5:2241-2250(1986). RN [5] {ECO:0000313|EMBL:AAA88094.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Promyelocytic leukemia {ECO:0000313|EMBL:AAA88094.1}; RX PubMed=3540591; RA Bentley D.L., Groudine M.; RT "Novel promoter upstream of the human c-myc gene and regulation of c- RT myc expression in B-cell lymphomas."; RL Mol. Cell. Biol. 6:3481-3489(1986). RN [6] {ECO:0000313|EMBL:CAA25105.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=3243428; DOI=10.1016/0378-1119(88)90131-X; RA Guilhot S., Petridou B., Syed-Hussain S., Galibert F.; RT "Nucleotide sequence 3' to the human c-myc oncogene; presence of a RT long inverted repeat."; RL Gene 72:105-108(1988). RN [7] {ECO:0000313|EMBL:AAA59887.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Leukemia {ECO:0000313|EMBL:AAA59887.1}; RX PubMed=2834731; DOI=10.1073/pnas.85.9.3052; RA Finver S.N., Nishikura K., Finger L.R., Haluska F.G., Finan J., RA Nowell P.C., Croce C.M.; RT "Sequence analysis of the MYC oncogene involved in the RT t(8;14)(q24;q11) chromosome translocation in a human leukemia T-cell RT line indicates that putative regulatory regions are not altered."; RL Proc. Natl. Acad. Sci. U.S.A. 85:3052-3056(1988). RN [8] {ECO:0000313|Ensembl:ENSP00000493145, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16421571; DOI=10.1038/nature04406; RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., RA Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., RA Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., RA Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T., RA Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., RA DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., RA Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., RA Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., RA O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., RA Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., RA Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., RA Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., RA Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., RA Lander E.S.; RT "DNA sequence and analysis of human chromosome 8."; RL Nature 439:331-335(2006). RN [9] {ECO:0000313|Ensembl:ENSP00000493145} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2017) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC103819; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; J03253; AAA59887.1; -; Genomic_DNA. DR EMBL; M14206; AAA88090.1; -; Genomic_DNA. DR EMBL; M13930; AAA88094.1; -; mRNA. DR EMBL; X00364; CAA25105.1; -; Genomic_DNA. DR PIR; A29867; A29867. DR PIR; I79500; I79500. DR SMR; Q16591; -. DR PRIDE; Q16591; -. DR Ensembl; ENST00000641036; ENSP00000493145; ENSG00000136997. DR HGNC; HGNC:7553; MYC. DR OpenTargets; ENSG00000136997; -. DR GeneTree; ENSGT00940000155285; -. DR ChiTaRS; MYC; human. DR Proteomes; UP000005640; Chromosome 8. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT REGION 1 51 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 102 134 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 37 51 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 109 123 Pro-rich. {ECO:0000256|SAM:MobiDB-lite}. SQ SEQUENCE 188 AA; 20955 MW; 677ADDDAC541477B CRC64; MRGSGRLRTP ELCCSRPPPP GPGRPWLPSC LEKGRASQRL GGKKNGGRDR AEYKSRFSGL YLTRCSNSSE RQRERAGGRL GWKSRASRAA LRASWEGRSG ANRGLRLWPS PPADPPASGP QPLPHPRNFA HSSGRALCTG TYNTRARTRL SRRGEAILPI WGHFPAAART RFSERLSLQL LRRWIFFG //