ID CIP4_HUMAN Reviewed; 545 AA. AC Q15642; O15184; Q5TZN1; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 18-OCT-2001, sequence version 2. DT 31-OCT-2006, entry version 55. DE Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) DE (TRIP-10). GN Name=TRIP10; Synonyms=CIP4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=97362357; PubMed=9210375; DOI=10.1016/S0960-9822(06)00219-3; RA Aspenstroem P.; RT "A Cdc42 target protein with homology to the non-kinase domain of FER RT has a potential role in regulating the actin cytoskeleton."; RL Curr. Biol. 7:479-487(1997). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Muscle; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 431-545. RX MEDLINE=95295737; PubMed=7776974; DOI=10.1210/me.9.2.243; RA Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.; RT "Two classes of proteins dependent on either the presence or absence RT of thyroid hormone for interaction with the thyroid hormone RT receptor."; RL Mol. Endocrinol. 9:243-254(1995). CC -!- FUNCTION: May act as a link between CDC42 signaling and regulation CC of the actin cytoskeleton. CC -!- SUBUNIT: Specifically interact with the ligand binding domain of CC the thyroid receptor (TR). Requires the presence of thyroid CC hormone for its interaction. Binds to CDC42. CC -!- TISSUE SPECIFICITY: Expressed most abundantly in skeletal muscle, CC heart and placenta, present at lower levels in pancreas, lung, CC liver, and kidney, and barely detectable in brain. CC -!- SIMILARITY: Contains 1 FCH domain. CC -!- SIMILARITY: Contains 1 SH3 domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ000414; CAA04062.1; -; mRNA. DR EMBL; BT006698; AAP35344.1; -; mRNA. DR EMBL; BT020167; AAV38969.1; -; mRNA. DR EMBL; BT020171; AAV43773.1; -; mRNA. DR EMBL; BC013002; AAH13002.1; -; mRNA. DR EMBL; L40379; AAC41729.1; -; mRNA. DR UniGene; Hs.515094; -. DR PDB; 2CT4; NMR; A=487-543. DR Ensembl; ENSG00000125733; Homo sapiens. DR KEGG; hsa:9322; -. DR H-InvDB; HIX0014704; -. DR HGNC; HGNC:12304; TRIP10. DR MIM; 604504; gene. DR ArrayExpress; Q15642; -. DR RZPD-ProtExp; M0526; -. DR RZPD-ProtExp; RZPDo834A0822; -. DR RZPD-ProtExp; RZPDo839D1164; -. DR GO; GO:0005737; C:cytoplasm; NAS:UniProtKB. DR GO; GO:0005515; F:protein binding; TAS:ProtInc. DR GO; GO:0030036; P:actin cytoskeleton organization and biogenesis; NAS:UniProtKB. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR InterPro; IPR001060; Cdc15_Fes_CIP4. DR InterPro; IPR011072; PKN_effector. DR InterPro; IPR001452; SH3. DR Pfam; PF00611; FCH; 1. DR Pfam; PF00018; SH3_1; 1. DR PRINTS; PR00452; SH3DOMAIN. DR ProDom; PD000066; SH3; 2. DR SMART; SM00055; FCH; 1. DR SMART; SM00326; SH3; 1. DR PROSITE; PS50133; FCH; 1. DR PROSITE; PS50002; SH3; 1. KW 3D-structure; Coiled coil; SH3 domain. FT CHAIN 1 545 Cdc42-interacting protein 4. FT /FTId=PRO_0000089766. FT DOMAIN 1 65 FCH. FT DOMAIN 484 545 SH3. FT COILED 101 178 Potential. FT CONFLICT 431 443 ARPPDPPASAPPD -> KHPIICRLIHFSN (in Ref. FT 4). FT STRAND 488 493 FT TURN 500 501 FT TURN 507 508 FT STRAND 510 515 FT STRAND 518 520 FT STRAND 522 526 FT STRAND 528 530 FT STRAND 532 536 FT HELIX 537 539 FT STRAND 540 542 SQ SEQUENCE 545 AA; 62592 MW; 9C9D72EA734BC6E2 CRC64; MDWGTELWDQ FEVLERHTQW GLDLLDRYVK FVKERTEVEQ AYAKQLRSLV KKYLPKRPAK DDPESKFSQQ QSFVQILQEV NDFAGQRELV AENLSVRVCL ELTKYSQEMK QERKMHFQEG RRAQQQLENG FKQLENSKRK FERDCREAEK AAQTAERLDQ DINATKADVE KAKQQAHLRS HMAEESKNEY AAQLQRFNRD QAHFYFSQMP QIFDKLQDMD ERRATRLGAG YGLLSEAELE VVPIIAKCLE GMKVAANAVD PKNDSHVLIE LHKSGFARPG DVEFEDFSQP MNRAPSDSSL GTPSDGRPEL RGPGRSRTKR WPFGKKNKTV VTEDFSHLPP EQQRKRLQQQ LEERSRELQK EVDQREALKK MKDVYEKTPQ MGDPASLEPQ IAETLSNIER LKLEVQKYEA WLAEAESRVL SNRGDSLSRH ARPPDPPASA PPDSSSNSAS QDTKESSEEP PSEESQDTPI YTEFDEDFEE EPTSPIGHCV AIYHFEGSSE GTISMAEGED LSLMEEDKGD GWTRVRRKEG GEGYVPTSYL RVTLN //