ID TR10_HUMAN STANDARD; PRT; 115 AA. AC Q15642; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 01-NOV-1997 (Rel. 35, Last annotation update) DE THYROID RECEPTOR INTERACTING PROTEIN 10 (TRIP10) (FRAGMENT). GN TRIP10. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 95295737. RA Lee J.W., Choi H.-S., Gyuris J., Brent R., Moore D.D.; RT "Two classes of proteins dependent on either the presence or absence RT of thyroid hormone for interaction with the thyroid hormone RT receptor."; RL Mol. Endocrinol. 9:243-254(1995). CC -!- FUNCTION: THYROID RECEPTOR INTERACTING PROTEINS (TRIPS) CC SPECIFICALLY INTERACT WITH THE LIGAND BINDING DOMAIN OF THE CC THYROID RECEPTOR (TR). TRIP10 REQUIRES THE PRESENCE OF THYROID CC HORMONE FOR ITS INTERACTION. CC -!- TISSUE SPECIFICITY: EXPRESSED MOST ABUNDANTLY IN SKELETAL MUSCLE, CC HEART AND LUNG. CC -!- SIMILARITY: CONTAINS 1 SH3 DOMAIN. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L40379; AAC41729.1; -. DR INTERPRO; IPR001452; -. DR PFAM; PF00018; SH3; 1. DR PROSITE; PS50002; SH3; 1. KW SH3 domain. FT NON_TER 1 1 FT DOMAIN 60 115 SH3. SQ SEQUENCE 115 AA; 12848 MW; 54CD7DCDBFC10308 CRC64; KHPIICRLIH FSNSSSNSAS QDTKESSEEP PSEESQDTPI YTEFDEDFEE EPTSPIGHCV AIYHFEGSSE GTISMAEGED LSLMEEDKGD GWTRVRRKEG GEGYVPTSYL RVTLN //