ID K6A1_HUMAN STANDARD; PRT; 735 AA. AC Q15418; Q96C05; DT 15-DEC-1998 (Rel. 37, Created) DT 15-JUN-2002 (Rel. 41, Last sequence update) DT 15-JUN-2002 (Rel. 41, Last annotation update) DE Ribosomal protein S6 kinase alpha 1 (EC 2.7.1.-) (S6K-alpha 1) (90 DE kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) DE (RSK-1) (pp90RSK1). GN RPS6KA1 OR RSK1. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=94189676; PubMed=8141249; RA Moller D.E., Xia C.-H., Tang W., Zhu A.X., Jakubowski M.; RT "Human rsk isoforms: cloning and characterization of tissue-specific RT expression."; RL Am. J. Physiol. 266:C351-C359(1994). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Colon; RA Strausberg R.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: PHOSPHORYLATES A WIDE RANGE OF SUBSTRATES INCLUDING CC RIBOSOMAL PROTEIN S6. IMPLICATED IN THE ACTIVATION OF THE MITOGEN- CC ACTIVATED KINASE CASCADE. CC -!- SIMILARITY: BELONGS TO THE SER/THR FAMILY OF PROTEIN KINASES. CC S6 KINASE SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L07597; AAC82497.1; -. DR EMBL; BC014966; AAH14966.1; -. DR HSSP; Q63450; 1A06. DR Genew; HGNC:10430; RPS6KA1. DR MIM; 601684; -. DR InterPro; IPR000719; Euk_pkinase. DR InterPro; IPR000961; Pkinase_C. DR InterPro; IPR002290; Ser_thr_pkinase. DR Pfam; PF00069; pkinase; 2. DR Pfam; PF00433; pkinase_C; 1. DR PRINTS; PR00109; TYRKINASE. DR ProDom; PD000001; Prot_kinase; 2. DR SMART; SM00133; S_TK_X; 1. DR SMART; SM00220; S_TKc; 2. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2. KW Transferase; Serine/threonine-protein kinase; ATP-binding; KW Repeat; Multigene family. FT DOMAIN 62 321 PROTEIN KINASE 1. FT DOMAIN 418 675 PROTEIN KINASE 2. FT NP_BIND 68 76 ATP (BY SIMILARITY). FT BINDING 94 94 ATP (BY SIMILARITY). FT ACT_SITE 187 187 BY SIMILARITY. FT NP_BIND 424 432 ATP (BY SIMILARITY). FT BINDING 447 447 ATP (BY SIMILARITY). FT ACT_SITE 535 535 BY SIMILARITY. FT CONFLICT 335 335 K -> T (IN REF. 1). SQ SEQUENCE 735 AA; 82723 MW; 765731A4442A53DF CRC64; MPLAQLKEPW PLMELVPLDP ENGQTSGEEA GLQPSKDEGV LKEISITHHV KAGSEKADPS HFELLKVLGQ GSFGKVFLVR KVTRPDSGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHS HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN PANRLGSGPD GAEEIKRHVF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP KDSPGIPPSA GAHQLFRGFS FVATGLMEDD GKPRAPQAPL HSVVQQLHGK NLVFSDGYVV KETIGVGSYS ECKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD DGKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLHTIG KTVEYLHSQG VVHRDLKPSN ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL GILLYTMLAG YTPFANGPSD TPEEILTRIG SGKFTLSGGN WNTVSETAKD LVSKMLHVDP HQRLTAKQVL QHPWVTQKDK LPQSQLSHQD LQLVKGAMAA TYSALNSSKP TPQLKPIESS ILAQRRVRKL PSTTL //