ID   IMB1_HUMAN     STANDARD;      PRT;   876 AA.
AC   Q14974; Q14637; Q96J27;
DT   01-NOV-1997 (Rel. 35, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Importin beta-1 subunit (Karyopherin beta-1 subunit) (Nuclear factor
DE   P97) (Importin 90).
GN   KPNB1 OR NTF97.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A., AND CHARACTERIZATION.
RC   TISSUE=Brain;
RX   MEDLINE=95340629; PubMed=7615630;
RA   Chi N.C., Adam E.J.H., Adam S.A.;
RT   "Sequence and characterization of cytoplasmic nuclear protein import
RT   factor p97.";
RL   J. Cell Biol. 130:265-274(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=95353691; PubMed=7627554;
RA   Goerlich D., Kostka S., Kraft R., Dingwall C., Laskey R.A.,
RA   Hartmann E., Prehn S.;
RT   "Two different subunits of importin cooperate to recognize nuclear
RT   localization signals and bind them to the nuclear envelope.";
RL   Curr. Biol. 5:383-392(1995).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain, and Eye;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [4]
RP   PARTIAL SEQUENCE, AND ALPHA SUBUNIT BINDING.
RX   MEDLINE=96203102; PubMed=8617227;
RA   Weis K., Ryder U., Lamond A.I.;
RT   "The conserved amino-terminal domain of hSRP1 alpha is essential for
RT   nuclear protein import.";
RL   EMBO J. 15:1818-1825(1996).
RN   [5]
RP   RAN-GTP AND ALPHA SUBUNIT BINDING SITES.
RX   MEDLINE=96293475; PubMed=8692944;
RA   Moroianu J., Blobel G., Radu A.;
RT   "Nuclear protein import: Ran-GTP dissociates the karyopherin
RT   alphabeta heterodimer by displacing alpha from an overlapping
RT   binding site on beta.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:7059-7062(1996).
CC   -!- FUNCTION: REQUIRED FOR NUCLEAR PROTEIN IMPORT AND MEDIATES DOCKING
CC       OF IMPORT SUBSTRATE TO DISTINCT NUCLEOPORINS. SERVES A RECEPTOR
CC       FOR NUCLEAR LOCALIZATION SIGNALS.
CC   -!- SUBUNIT: FORMS A COMPLEX WITH AN IMPORTIN ALPHA SUBUNIT.
CC   -!- SUBCELLULAR LOCATION: CYTOPLASMIC AND NUCLEAR ENVELOPE.
CC   -!- SIMILARITY: BELONGS TO THE IMPORTIN BETA FAMILY.
CC   -!- SIMILARITY: Contains 1 importin N-terminal domain.
CC   -!- SIMILARITY: Contains 8 HEAT repeats.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L39793; AAA82869.1; -.
DR   EMBL; L38951; AAC41763.1; -.
DR   EMBL; BC003572; AAH03572.1; -.
DR   EMBL; BC036703; AAH36703.1; -.
DR   Genew; HGNC:6400; KPNB1.
DR   MIM; 602738; -.
DR   GO; GO:0005737; C:cytoplasm; TAS.
DR   GO; GO:0005648; C:importin, beta-subunit; TAS.
DR   GO; GO:0005643; C:nuclear pore; TAS.
DR   GO; GO:0008139; F:nuclear localization sequence binding activity; TAS.
DR   GO; GO:0008270; F:zinc ion binding activity; TAS.
DR   GO; GO:0006607; P:NLS-bearing substrate-nucleus import; TAS.
DR   GO; GO:0000060; P:protein-nucleus import, translocation; TAS.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR000357; HEAT_repeat.
DR   InterPro; IPR001494; Importinb_N.
DR   Pfam; PF00514; Armadillo_seg; 3.
DR   Pfam; PF03810; IBN_NT; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
KW   Transport; Protein transport; Repeat; Nuclear protein.
FT   DOMAIN       21    101       IMPORTIN N-TERMINAL.
FT   REPEAT      124    163       HEAT 1.
FT   REPEAT      168    207       HEAT 2.
FT   REPEAT      213    250       HEAT 3.
FT   REPEAT      317    357       HEAT 4.
FT   REPEAT      362    399       HEAT 5.
FT   REPEAT      404    441       HEAT 6.
FT   DOMAIN      329    342       IAB BINDING.
FT   DOMAIN      334    419       RAN-GTP BINDING.
FT   REPEAT      602    641       HEAT 7.
FT   REPEAT      687    726       HEAT 8.
FT   DOMAIN      337    341       POLY-ASP.
FT   CONFLICT     97     97       Q -> H (IN REF. 1).
FT   CONFLICT    200    200       N -> NA (IN REF. 4).
FT   CONFLICT    863    863       T -> R (IN REF. 1).
SQ   SEQUENCE   876 AA;  97169 MW;  F3BB8B73E7E51639 CRC64;
     MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ
     IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG TETYRPSSAS QCVAGIACAE
     IPVNQWPELI PQLVANVTNP NSTEHMKEST LEAIGYICQD IDPEQLQDKS NEILTAIIQG
     MRKEEPSNNV KLAATNALLN SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN
     LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
     AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLATCCE
     DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GCILEGPEPS QLKPLVIQAM PTLIELMKDP
     SVVVRDTAAW TVGRICELLP EAAINDVYLA PLLQCLIEGL SAEPRVASNV CWAFSSLAEA
     AYEAADVADD QEEPATYCLS SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA
     KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
     LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF KPFLGIGLKN
     YAEYQVCLAA VGLVGDLCRA LQSNIIPFCD EVMQLLLENL GNENVHRSVK PQILSVFGDI
     ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS DYDMVDYLNE LRESCLEAYT GIVQGLKGDQ
     ENVHPDVMLV QPRVEFILSF IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR
     PMIHELLTEG RRSKTNKAKT LATWATKELR KLKNQA
//