ID K1H2_HUMAN Reviewed; 448 AA. AC Q14532; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 15-JUL-1999, sequence version 2. DT 12-DEC-2006, entry version 43. DE Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2). GN Name=KRTHA2; Synonyms=HHA2, HKA2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Hair; RX MEDLINE=96032808; PubMed=7556444; DOI=10.1006/excr.1995.1326; RA Rogers M.A., Nischt R., Korge B., Krieg T., Fink T.M., Lichter P., RA Winter H., Schweizer J.; RT "Sequence data and chromosomal localization of human type I and type RT II hair keratin genes."; RL Exp. Cell Res. 220:357-362(1995). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Hair; RX MEDLINE=96420675; PubMed=8823373; DOI=10.1111/1523-1747.ep12584243; RA Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J.; RT "Genomic characterization of the human type I cuticular hair keratin RT hHa2 and identification of an adjacent novel type I hair keratin gene RT hHa5."; RL J. Invest. Dermatol. 107:633-638(1996). RN [3] RP SEQUENCE REVISION TO N-TERMINUS. RA Rogers M.A.; RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. CC -!- TISSUE SPECIFICITY: Restricted to the hair cuticle. CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, CC I (acidic) and II (neutral to basic). CC -!- SIMILARITY: Belongs to the intermediate filament family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X81419; CAA57179.1; ALT_INIT; mRNA. DR EMBL; X90761; CAA62284.1; -; Genomic_DNA. DR HSSP; P08670; 1GK7. DR GermOnline; ENSG00000108759; Homo sapiens. DR Ensembl; ENSG00000108759; Homo sapiens. DR KEGG; hsa:3882; -. DR HGNC; HGNC:6449; KRTHA2. DR MIM; 602760; gene. DR ArrayExpress; Q14532; -. DR RZPD-ProtExp; D0362; -. DR RZPD-ProtExp; T1807; -. DR GO; GO:0008544; P:epidermis development; TAS:ProtInc. DR InterPro; IPR011000; ApoLp_III_like. DR InterPro; IPR001664; IF. DR InterPro; IPR002957; Keratin_I. DR Pfam; PF00038; Filament; 1. DR PRINTS; PR01248; TYPE1KERATIN. DR PROSITE; PS00226; IF; 1. KW Coiled coil; Intermediate filament; Keratin. FT CHAIN 1 448 Keratin, type I cuticular Ha2. FT /FTId=PRO_0000063686. FT REGION 1 96 Head. FT REGION 97 403 Rod. FT REGION 97 131 Coil 1A. FT REGION 132 142 Linker 1. FT REGION 143 243 Coil 1B. FT REGION 244 259 Linker 12. FT REGION 260 403 Coil 2. FT REGION 404 448 Tail. FT SITE 345 345 Stutter. SQ SEQUENCE 448 AA; 50319 MW; 35B42ADD2397D128 CRC64; MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV CLPTTFRPAS CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM QFLNDRLASY LTRVRQLEQE NAELESRIQE ASHSQVLTMT PDYQSHFRTI DQLQQKILCT KAENARMVVN IDNAKLAADD FRAKYEAELA MRQLVEADIN GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS LRCQLGDRLN IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ LAQMQCMITN VEAQLAEIRA ELERQNQEYQ VLLDVRARLE GEINTYRSLL ESEDCKLPCN PCSTPSCTTC VPSPCVTRTV CVPRTVGMPC SPCPQGRY //