ID K1M2_HUMAN STANDARD; PRT; 405 AA. AC Q14532; DT 15-JUL-1998 (REL. 36, CREATED) DT 15-JUL-1998 (REL. 36, LAST SEQUENCE UPDATE) DT 15-JUL-1998 (REL. 36, LAST ANNOTATION UPDATE) DE KERATIN, TYPE I CUTICULAR HA2 (HAIR KERATIN, TYPE I HA2). GN HKA2. OS HOMO SAPIENS (HUMAN). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; PRIMATES. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=HAIR; RX MEDLINE; 96032808. RA ROGERS M.A., NISCHT R., KORGE B., KRIEG T., FINK T.M., LICHTER P., RA WINTER H., SCHWEIZER J.; RL EXP. CELL RES. 220:357-362(1995). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=HAIR; RX MEDLINE; 96420675. RA ROGERS M.A., WINTER H., LANGBEIN L., KRIEG T., SCHWEIZER J.; RL J. INVEST. DERMATOL. 107:633-638(1996). CC -!- THERE ARE TWO TYPES OF HAIR/MICROFIBRILLAR KERATIN, I (ACIDIC) AND CC II (NEUTRAL TO BASIC). CC -!- SIMILARITY: BELONGS TO THE INTERMEDIATE FILAMENT FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X81419; E134904; -. DR EMBL; X90761; E195474; -. DR MIM; 601077; -. DR PROSITE; PS00226; IF; 1. KW INTERMEDIATE FILAMENT; COILED COIL; HEPTAD REPEAT PATTERN; KERATIN. FT DOMAIN 1 53 HEAD. FT DOMAIN 54 360 ROD. FT DOMAIN 361 405 TAIL. FT DOMAIN 54 88 COIL 1A. FT DOMAIN 89 99 LINKER 1. FT DOMAIN 100 200 COIL 1B. FT DOMAIN 201 216 LINKER 12. FT DOMAIN 217 360 COIL 2. FT SITE 302 302 STUTTER. SQ SEQUENCE 405 AA; 45828 MW; 65F59364 CRC32; MACLPSVCLP TTFRPASCLS KTYLSSSCQA ASGISGSMGP GSWYSEGAFN GNEKETMQFL NDRLASYLTR VRQLEQENAE LESRIQEASH SQVLTMTPDY QSHFRTIDQL QQKILCTKAE NARMVVNIDN AKLAADDFRA KYEAELAMRQ LVEADINGLR RILDDLTLCK ADLEAQVESL KEELMCLKKN HEEEVGSLRC QLGDRLNIEV DAAPPVDLTR VLEEMRCQYE AMVEANRRDV EEWFNMQMEE LNQQVATSSE QLQNYQSDII DLRRTVNTLE IELQAQHSLR DSLENTLTES EARYSSQLAQ MQCMITNVEA QLAEIRAELE RQNQEYQVLL DVRARLEGEI NTYRSLLESE DCKLPCNPCS TPSCTTCVPS PCVTRTVCVP RTVGMPCSPC PQGRY //