ID K1H2_HUMAN STANDARD; PRT; 448 AA. AC Q14532; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Keratin, type I cuticular HA2 (Hair keratin, type I HA2). GN Name=KRTHA2; Synonyms=HKA2, HHA2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Hair; RX MEDLINE=96032808; PubMed=7556444; RA Rogers M.A., Nischt R., Korge B., Krieg T., Fink T.M., Lichter P., RA Winter H., Schweizer J.; RT "Sequence data and chromosomal localization of human type I and type RT II hair keratin genes."; RL Exp. Cell Res. 220:357-362(1995). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Hair; RX MEDLINE=96420675; PubMed=8823373; RA Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J.; RT "Genomic characterization of the human type I cuticular hair keratin RT hHa2 and identification of an adjacent novel type I hair keratin gene RT hHa5."; RL J. Invest. Dermatol. 107:633-638(1996). RN [3] RP REVISIONS TO N-TERMINUS. RA Rogers M.A.; RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. CC -!- TISSUE SPECIFICITY: Restricted to the hair cuticle. CC -!- MISCELLANEOUS: There are two types of hair/microfibrillar keratin, CC I (acidic) and II (neutral to basic). CC -!- SIMILARITY: Belongs to the intermediate filament family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X81419; CAA57179.1; ALT_INIT. DR EMBL; X90761; CAA62284.1; -. DR HSSP; P08670; 1GK7. DR Genew; HGNC:6449; KRTHA2. DR MIM; 602760; -. DR GO; GO:0008544; P:epidermal differentiation; TAS. DR InterPro; IPR001664; IF. DR InterPro; IPR002957; Keratin_I. DR Pfam; PF00038; Filament; 1. DR PRINTS; PR01248; TYPE1KERATIN. DR PROSITE; PS00226; IF; 1. KW Intermediate filament; Coiled coil; Keratin. FT DOMAIN 1 96 Head. FT DOMAIN 97 403 Rod. FT DOMAIN 404 448 Tail. FT DOMAIN 97 131 Coil 1A. FT DOMAIN 132 142 Linker 1. FT DOMAIN 143 243 Coil 1B. FT DOMAIN 244 259 Linker 12. FT DOMAIN 260 403 Coil 2. FT SITE 345 345 Stutter. SQ SEQUENCE 448 AA; 50318 MW; 35B42ADD2397D128 CRC64; MTSSCCVTNN LQASLKSCPR PASVCSSGVN CRPELCLGYV CQPMACLPSV CLPTTFRPAS CLSKTYLSSS CQAASGISGS MGPGSWYSEG AFNGNEKETM QFLNDRLASY LTRVRQLEQE NAELESRIQE ASHSQVLTMT PDYQSHFRTI DQLQQKILCT KAENARMVVN IDNAKLAADD FRAKYEAELA MRQLVEADIN GLRRILDDLT LCKADLEAQV ESLKEELMCL KKNHEEEVGS LRCQLGDRLN IEVDAAPPVD LTRVLEEMRC QYEAMVEANR RDVEEWFNMQ MEELNQQVAT SSEQLQNYQS DIIDLRRTVN TLEIELQAQH SLRDSLENTL TESEARYSSQ LAQMQCMITN VEAQLAEIRA ELERQNQEYQ VLLDVRARLE GEINTYRSLL ESEDCKLPCN PCSTPSCTTC VPSPCVTRTV CVPRTVGMPC SPCPQGRY //