ID SLI3_HUMAN STANDARD; PRT; 279 AA. AC Q14192; Q13229; Q13644; Q9P294; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Skeletal muscle LIM-protein 3 (SLIM 3) (LIM-domain protein DRAL) DE (Four and a half LIM domains protein 2) (FHL-2). GN FHL2 OR SLIM3 OR DRAL. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Skeletal muscle; RX MEDLINE=97294674; PubMed=9150430; RA Genini M., Schwalbe P., Scholl F.A., Remppis A., Mattei M.-G., RA Schaefer B.W.; RT "Subtractive cloning and characterization of DRAL, a novel LIM-domain RT protein down-regulated in rhabdomyosarcoma."; RL DNA Cell Biol. 16:433-442(1997). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Heart; RX MEDLINE=98248917; PubMed=9573400; RA Chan K.K., Tsui S.K.W., Lee S.M.Y., Luk S.C.W., Liew C.C., Fung K.P., RA Waye M.M.Y., Lee C.Y.; RT "Molecular cloning and characterization of FHL2, a novel LIM domain RT protein preferentially expressed in human heart."; RL Gene 210:345-350(1998). RN [3] RP SEQUENCE FROM N.A. RC TISSUE=Leukocyte; RX MEDLINE=20458893; PubMed=11001931; RA Tanahashi H., Tabira T.; RT "Alzheimer's disease-associated presenilin 2 interacts with DRAL, an RT LIM-domain protein."; RL Hum. Mol. Genet. 9:2281-2289(2000). RN [4] RP SEQUENCE FROM N.A. RC TISSUE=Placenta; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [5] RP SEQUENCE OF 127-279 FROM N.A. RC TISSUE=Heart muscle; RX MEDLINE=96354835; PubMed=8753811; RA Morgan M.J., Madgwick A.J.A.; RT "Slim defines a novel family of LIM-proteins expressed in skeletal RT muscle."; RL Biochem. Biophys. Res. Commun. 225:632-638(1996). CC -!- TISSUE SPECIFICITY: Expressed only in skeletal muscle. CC -!- SIMILARITY: Contains 4 LIM zinc-binding domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L42176; AAA85333.1; -. DR EMBL; U29332; AAC52073.1; -. DR EMBL; AB038794; BAA92253.1; -. DR EMBL; AB038991; BAA92253.1; JOINED. DR EMBL; AB038992; BAA92253.1; JOINED. DR EMBL; AB038792; BAA92253.1; JOINED. DR EMBL; AB038793; BAA92253.1; JOINED. DR EMBL; BC014397; AAH14397.1; -. DR EMBL; U60117; AAC50794.1; -. DR PIR; JC6565; JC6565. DR HSSP; P48059; 1NYP. DR Genew; HGNC:3703; FHL2. DR MIM; 602633; -. DR GO; GO:0005634; C:nucleus; TAS. DR InterPro; IPR001781; LIM. DR Pfam; PF00412; LIM; 4. DR ProDom; PD000094; LIM; 4. DR SMART; SM00132; LIM; 4. DR PROSITE; PS00478; LIM_DOMAIN_1; 4. DR PROSITE; PS50023; LIM_DOMAIN_2; 4. KW Repeat; LIM domain; Metal-binding; Zinc; Zinc-finger. FT ZN_FING 7 31 GATA-like (Potential). FT DOMAIN 40 92 LIM 1. FT DOMAIN 101 153 LIM 2. FT DOMAIN 162 212 LIM 3. FT DOMAIN 221 275 LIM 4. FT CONFLICT 167 167 M -> G (in Ref. 1). FT CONFLICT 167 167 M -> K (in Ref. 3 and 4). SQ SEQUENCE 279 AA; 32196 MW; DBDC77C9BD6C4BBA CRC64; MTERFDCHHC NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD CKDLSYKDRH WHEACFHCSQ CRNSLVDKPF AAKEDQLLCT DCYSNEYSSK CQECKKTIMP GTRKMEYKGS SWHETCFICH RCQQPIGTKS FIPKDNQNFC VPCYEKQHAM QCVQCKMPIT TGGVTYREQP WHKECFVCTA CRKQLSGQRF TARDDFAYCL NCFCDLYAKK CAGCTNPISG LGGTKYISFE ERQWHNDCFN CKKCSLSLVG RGFLTERDDI LCPDCGKDI //