ID SLI3_HUMAN STANDARD; PRT; 279 AA. AC Q14192; Q13229; Q13644; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 20-AUG-2001 (Rel. 40, Last annotation update) DE SKELETAL MUSCLE LIM-PROTEIN 3 (SLIM 3) (LIM-DOMAIN PROTEIN DRAL) DE (FOUR AND A HALF LIM DOMAINS PROTEIN 2) (FHL-2). GN FHL2 OR SLIM3 OR DRAL. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Skeletal muscle; RX MEDLINE=97294674; PubMed=9150430; RA Genini M., Schwalbe P., Scholl F.A., Remppis A., Mattei M.-G., RA Schaefer B.W.; RT "Subtractive cloning and characterization of DRAL, a novel LIM-domain RT protein down-regulated in rhabdomyosarcoma."; RL DNA Cell Biol. 16:433-442(1997). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=Heart; RX MEDLINE=98248917; PubMed=9573400; RA Chan K.K., Tsui S.K.W., Lee S.M.Y., Luk S.C.W., Liew C.C., Fung K.P., RA Waye M.M.Y., Lee C.Y.; RT "Molecular cloning and characterization of FHL2, a novel LIM domain RT protein preferentially expressed in human heart."; RL Gene 210:345-350(1998). RN [3] RP SEQUENCE OF 127-279 FROM N.A. RC TISSUE=Heart muscle; RX MEDLINE=96354835; PubMed=8753811; RA Morgan M.J., Madgwick A.J.A.; RT "Slim defines a novel family of LIM-proteins expressed in skeletal RT muscle."; RL Biochem. Biophys. Res. Commun. 225:632-638(1996). CC -!- TISSUE SPECIFICITY: EXPRESSED ONLY IN SKELETAL MUSCLE. CC -!- SIMILARITY: CONTAINS 4 LIM DOMAINS. THE LIM DOMAIN BINDS 2 ZINC CC IONS. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L42176; AAA85333.1; -. DR EMBL; U29332; AAC52073.1; -. DR EMBL; U60117; AAC50794.1; -. DR MIM; 602633; -. DR InterPro; IPR001781; LIM. DR Pfam; PF00412; LIM; 5. DR ProDom; PD000094; LIM; 4. DR SMART; SM00132; LIM; 4. DR PROSITE; PS00478; LIM_DOMAIN_1; 4. DR PROSITE; PS50023; LIM_DOMAIN_2; 4. KW Repeat; LIM motif; Metal-binding; Zinc; Zinc-finger. FT ZN_FING 7 31 GATA-LIKE (POTENTIAL). FT DOMAIN 40 92 LIM 1. FT DOMAIN 101 153 LIM 2. FT DOMAIN 162 212 LIM 3. FT DOMAIN 221 275 LIM 4. FT CONFLICT 167 167 M -> G (IN REF. 1). SQ SEQUENCE 279 AA; 32196 MW; DBDC77C9BD6C4BBA CRC64; MTERFDCHHC NESLFGKKYI LREESPYCVV CFETLFANTC EECGKPIGCD CKDLSYKDRH WHEACFHCSQ CRNSLVDKPF AAKEDQLLCT DCYSNEYSSK CQECKKTIMP GTRKMEYKGS SWHETCFICH RCQQPIGTKS FIPKDNQNFC VPCYEKQHAM QCVQCKMPIT TGGVTYREQP WHKECFVCTA CRKQLSGQRF TARDDFAYCL NCFCDLYAKK CAGCTNPISG LGGTKYISFE ERQWHNDCFN CKKCSLSLVG RGFLTERDDI LCPDCGKDI //