ID   CD2L5_HUMAN             Reviewed;        1512 AA.
AC   Q14004; Q6DKQ9; Q75MH4; Q75MH5; Q96JN4; Q9H4A0; Q9H4A1; Q9UDR4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 2.
DT   12-DEC-2006, entry version 61.
DE   Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2-
DE   related protein kinase 5) (Cholinesterase-related cell division
DE   controller).
GN   Name=CDC2L5; Synonyms=CDC2L, CHED, KIAA1791;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT LEU-700.
RC   TISSUE=Placenta;
RX   PubMed=11162436; DOI=10.1006/bbrc.2000.4042;
RA   Marques F., Moreau J.L., Peaucellier G., Lozano J.C., Schatt P.,
RA   Picard A., Callebaut I., Perre E., Geneviere A.M.;
RT   "A new subfamily of high molecular mass CDC2-related kinases with
RT   PITAI/VRE.";
RL   Biochem. Biophys. Res. Commun. 279:832-837(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-356; PHE-403;
RP   GLN-410; ALA-500; GLY-624 AND MET-1062.
RA   Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N.,
RA   Nguyen C.P., Nguyen D.A., Poel C.L., Chambers S.W., Schackwitz W.S.,
RA   Sherwood J.K., Sherwood A.M., Leithauser B.J., Nickerson D.A.;
RT   "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department
RT   of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22737999; PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 361-1078, AND VARIANT LEU-700.
RC   TISSUE=Glioblastoma;
RX   MEDLINE=92115704; PubMed=1731328;
RA   Lapidot-Lifson Y., Patinkin D., Prody C.A., Ehrlich G., Seidman S.,
RA   Ben-Aziz R., Benseler F., Eckstein F., Zakut H., Soreq H.;
RT   "Cloning and antisense oligodeoxynucleotide inhibition of a human
RT   homolog of cdc2 required in hematopoiesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:579-583(1992).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 860-1512 (ISOFORM 1).
RC   TISSUE=Brain;
RX   MEDLINE=21245130; PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA   Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XX.
RT   The complete sequences of 100 new cDNA clones from brain which code
RT   for large proteins in vitro.";
RL   DNA Res. 8:85-95(2001).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437 AND THR-442, AND
RP   MASS SPECTROMETRY.
RX   PubMed=15144186; DOI=10.1021/ac035352d;
RA   Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,
RA   Peters E.C.;
RT   "Robust phosphoproteomic profiling of tyrosine phosphorylation sites
RT   from human T cells using immobilized metal affinity chromatography and
RT   tandem mass spectrometry.";
RL   Anal. Chem. 76:2763-2772(2004).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-340; SER-342;
RP   SER-367 AND SER-383, AND MASS SPECTROMETRY.
RX   PubMed=15302935; DOI=10.1073/pnas.0404720101;
RA   Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,
RA   Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
RT   "Large-scale characterization of HeLa cell nuclear phosphoproteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437 AND SER-441, AND
RP   MASS SPECTROMETRY.
RX   PubMed=16964243; DOI=10.1038/nbt1240;
RA   Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
RT   "A probability-based approach for high-throughput protein
RT   phosphorylation analysis and site localization.";
RL   Nat. Biotechnol. 24:1285-1292(2006).
CC   -!- FUNCTION: May be a controller of the mitotic cell cycle. Involved
CC       in the blood cell development.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q14004-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q14004-2; Sequence=VSP_013579;
CC   -!- TISSUE SPECIFICITY: Expressed in fetal brain, liver, muscle and in
CC       adult brain. Also expressed in neuroblastoma and glioblastoma
CC       tumors.
CC   -!- SIMILARITY: Belongs to the Ser/Thr protein kinase family.
CC       CDC2/CDKX subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- CAUTION: Ref.3 (AAS07490) sequence differs from that shown due to
CC       erroneous gene model prediction.
CC   -!- CAUTION: Ref.4 (AAA58424) sequence differs from that shown due to
CC       a frameshift in position 1006.
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DR   EMBL; AJ297709; CAC10400.1; -; mRNA.
DR   EMBL; AJ297710; CAC10401.1; -; mRNA.
DR   EMBL; AY679523; AAT74623.1; -; Genomic_DNA.
DR   EMBL; AC072061; AAS07490.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC072061; AAS07491.1; -; Genomic_DNA.
DR   EMBL; AC006023; AAD54514.1; -; Genomic_DNA.
DR   EMBL; M80629; AAA58424.1; ALT_SEQ; mRNA.
DR   EMBL; AB058694; BAB47420.1; -; mRNA.
DR   HSSP; P24941; 1P2A.
DR   IntAct; Q14004; -.
DR   GermOnline; ENSG00000065883; Homo sapiens.
DR   Ensembl; ENSG00000065883; Homo sapiens.
DR   KEGG; hsa:8621; -.
DR   HGNC; HGNC:1733; CDC2L5.
DR   MIM; 603309; gene.
DR   ArrayExpress; Q14004; -.
DR   RZPD-ProtExp; IOH3095; -.
DR   GO; GO:0004672; F:protein kinase activity; TAS:ProtInc.
DR   GO; GO:0007275; P:development; TAS:ProtInc.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
DR   GO; GO:0007088; P:regulation of mitosis; TAS:ProtInc.
DR   InterPro; IPR011009; Kinase_like.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
KW   Alternative splicing; ATP-binding; Kinase; Nucleotide-binding;
KW   Phosphorylation; Polymorphism; Serine/threonine-protein kinase;
KW   Transferase.
FT   CHAIN         1   1512       Cell division cycle 2-like protein kinase
FT                                5.
FT                                /FTId=PRO_0000085711.
FT   DOMAIN      705    998       Protein kinase.
FT   NP_BIND     711    719       ATP (By similarity).
FT   ACT_SITE    837    837       Proton acceptor (By similarity).
FT   BINDING     734    734       ATP (By similarity).
FT   MOD_RES     317    317       Phosphoserine.
FT   MOD_RES     340    340       Phosphoserine.
FT   MOD_RES     342    342       Phosphoserine.
FT   MOD_RES     367    367       Phosphoserine.
FT   MOD_RES     383    383       Phosphoserine.
FT   MOD_RES     437    437       Phosphoserine.
FT   MOD_RES     441    441       Phosphoserine.
FT   MOD_RES     442    442       Phosphothreonine.
FT   VAR_SEQ    1079   1138       Missing (in isoform 2).
FT                                /FTId=VSP_013579.
FT   VARIANT     356    356       P -> A.
FT                                /FTId=VAR_022381.
FT   VARIANT     403    403       L -> F (in dbSNP:rs3735137).
FT                                /FTId=VAR_022382.
FT   VARIANT     410    410       R -> Q.
FT                                /FTId=VAR_022383.
FT   VARIANT     500    500       T -> A (in dbSNP:rs3735135).
FT                                /FTId=VAR_022384.
FT   VARIANT     624    624       S -> G.
FT                                /FTId=VAR_022385.
FT   VARIANT     700    700       R -> L (in dbSNP:rs1057000).
FT                                /FTId=VAR_022386.
FT   VARIANT    1062   1062       V -> M.
FT                                /FTId=VAR_022387.
FT   CONFLICT     21     21       K -> R (in Ref. 1).
FT   CONFLICT    671    671       A -> T (in Ref. 1 and 4).
FT   CONFLICT    810    810       N -> Y (in Ref. 4).
FT   CONFLICT    862    866       YSSEE -> FSVFF (in Ref. 5).
FT   CONFLICT   1035   1035       Missing (in Ref. 4).
FT   CONFLICT   1170   1170       V -> M (in Ref. 1).
SQ   SEQUENCE   1512 AA;  164923 MW;  3CA54A3585A2943D CRC64;
     MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF
     LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG GRQKRRRGPR AGQEAEKRRV
     FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGSGGS
     PASSSGTQRR GEGSERRPRR DRRSSSGRSK ERHREHRRRD GQRGGSEASK SRSRHSHSGE
     ERAEVAKSGS SSSSGGRRKS ASATSSSSSS RKDRDSKAHR SRTKSSKEPP SAYKEPPKAY
     REDKTEPKAY RRRRSLSPLG GRDDSPVSHR ASQSLRSRKS PSPAGGGSSP YSRRLPRSPS
     PYSRRRSPSY SRHSSYERGG DVSPSPYSSS SWRRSRSPYS PVLRRSGKSR SRSPYSSRHS
     RSRSRHRLSR SRSRHSSISP STLTLKSSLA AELNKNKKAR AAEAARAAEA AKAAEATKAA
     EAAAKAAKAS NTSTPTKGNT ETSASASQTN HVKDVKKIKI EHAPSPSSGG TLKNDKAKTK
     PPLQVTKVEN NLIVDKATKK AVIVGKESKS AATKEESVSL KEKTKPLTPS IGAKEKEQHV
     ALVTSTLPPL PLPPMLPEDK EADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD
     LSKSPEEKKT ATQLHSKRRP KICGPRYGET KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY
     KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF
     KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC
     SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC
     GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL
     REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL
     WSKKRRRQKQ MGMTDDVSTI KAPRKDLSLG LDDSRTNTPQ GVLPSSQLKS QGSSNVAPVK
     TGPGQHLNHS ELAILLNLLQ SKTSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE
     KQTDPSTPQQ ESSKPLGGIQ PSSQTIQPKV ETDAAQAAVQ SAFAVLLTQL IKAQQSKQKD
     VLLEERENGS GHEASLQLRP PPEPSTPVSG QDDLIQHQDM RILELTPEPD RPRILPPDQR
     PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA ALLQLLAQHQ PQDDPKREGG
     IDYQAGDTYV STSDYKDNFG SSSFSSAPYV SNDGLGSSSA PPLERRSFIG NSDIQSLDNY
     STASSHSGGP PQPSAFSESF PSSVAGYGDI YLNAGPMLFS GDKDHRFEYS HGPIAVLANS
     SDPSTGPEST HPLPAKMHNY NYGGNLQENP SGPSLMHGQT WTSPAQGPGY SQGYRGHIST
     STGRGRGRGL PY
//