ID   CDL5_HUMAN     STANDARD;      PRT;   418 AA.
AC   Q14004;
DT   16-OCT-2001 (Rel. 40, Created)
DT   16-OCT-2001 (Rel. 40, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   Cell division cycle 2-like protein kinase 5 (EC 2.7.1.-)
DE   (Cholinesterase-related cell division controller) (CDC2-related
DE   protein kinase 5).
GN   CDC2L5 OR CDC2L OR CHED.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Glioblastoma;
RX   MEDLINE=92115704; PubMed=1731328;
RA   Lapidot-Lifson Y., Patinkin D., Prody C.A., Ehrlich G., Seidman S.,
RA   Ben-Aziz R., Benseler F., Eckstein F., Zakut H., Soreq H.;
RT   "Cloning and antisense oligodeoxynucleotide inhibition of a human
RT   homolog of cdc2 required in hematopoiesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:579-583(1992).
CC   -!- FUNCTION: MAY BE A CONTROLLER OF THE MITOTIC CELL CYCLE. INVOLVED
CC       IN THE BLOOD CELL DEVELOPMENT.
CC   -!- TISSUE SPECIFICITY: EXPRESSED IN FETAL BRAIN, LIVER, MUSCLE AND IN
CC       ADULT BRAIN. ALSO EXPRESSED IN NEUROBLASTOMA AND GLIOBLASTOMA
CC       TUMORS.
CC   -!- SIMILARITY: Belongs to the Ser/Thr family of protein kinases.
CC       CDC2/CDKX subfamily.
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DR   EMBL; M80629; AAA58424.1; -.
DR   HSSP; P24941; 1BUH.
DR   Genew; HGNC:1733; CDC2L5.
DR   GK; Q14004; -.
DR   MIM; 603309; -.
DR   GO; GO:0007275; P:development; TAS.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; TAS.
DR   GO; GO:0007088; P:regulation of mitosis; TAS.
DR   InterPro; IPR000719; Prot_kinase.
DR   InterPro; IPR002290; Ser_thr_pkinase.
DR   InterPro; IPR001245; Tyr_pkinase.
DR   Pfam; PF00069; pkinase; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
KW   Transferase; Serine/threonine-protein kinase; ATP-binding.
FT   DOMAIN       91    384       PROTEIN KINASE.
FT   NP_BIND      97    105       ATP (BY SIMILARITY).
FT   BINDING     120    120       ATP (BY SIMILARITY).
FT   ACT_SITE    223    223       BY SIMILARITY.
SQ   SEQUENCE   418 AA;  48211 MW;  4EBA77F1C48CD915 CRC64;
     MLPEDKEADS LRGNISVKAV KKEVEKKLRC LLADLPLPPE LPGGDDLSKS PEEKKTTTQL
     HSKRRPKICG PRYGETKEKD IDWGKLCVDK FDIIGIIGEG TYGQVYKARD KDTGEMVALK
     KVRLDNEKEG FPITAIREIK ILRQLTHQSI INMKEIVTDK EDALDFKKDK GAFYLVFEYM
     DHDLMGLLES GLVHFYENHI KSFMRQLMEG LDYCHKKNFL HRDIKCSNIL LNNRGQIKLA
     DFGLARLYSS EESRPYTNKV ITLWYRPPEL LLGEERYTPA IDVWSCGCIL GELFTKKPIF
     QANQELAQLE LISRICGSPC PAVWPDVIKL PYFNTMKPKK QYRRKLREEF VFIPAAALDL
     FDYMLALDPS KRCTAEQALQ CEFLRDVEPS KCLHQISLYG KIVMSYGVKS EEDRSRWA
//