ID Q13948 PRELIMINARY; PRT; 678 AA. AC Q13948; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 01-MAR-2003 (TrEMBLrel. 23, Last annotation update) DE CASP. GN Name=CASP; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Umbilical vein; RA Lievens P.M.J., Neufeld E.J.; RL Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Binds to actin filaments in muscle and nonmuscle cells. CC Plays a central role, in association with the troponin complex, in CC the calcium dependent regulation of vertebrate striated muscle CC contraction. Smooth muscle contraction is regulated by interaction CC with caldesmon. In nonmuscle cells is implicated in stabilizing CC cytoskeleton actin filaments (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L12579; AAA35654.1; -. DR Ensembl; ENSG00000160967; Homo sapiens. DR InterPro; IPR000533; Tropomyosin. DR PRINTS; PR00194; TROPOMYOSIN. KW Actin-binding; Cytoskeleton; Muscle protein. SQ SEQUENCE 678 AA; 77420 MW; E587F2228253C91E CRC64; MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL NVYKRLIDVP DPVPALDLGQ QLQLKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI KALKEKIREY EQTLKNQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK LEEAEHKVQS LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLSAKNSTLK QLEEKLKGQA DYEEVKKELN ILKSMEFAPS EGAGTQDAAK PLEVLLLEKN RSLQSENAAL RISNSDLSGR CAELQVRITE AVATATEQRE LIARLEQDLS IIQSIQRPDA EGAAEHRLEK IPEPIKEATA LFYGPAAPAS GALPEGQVDS LLSIISSQRE RFRARNQELE AENRLAQHTL QALQSELDSL RADNIKLFEK IKFLQSYPGR GSGSDDTELR YSSQYEERLD PFSSFSKRER QRKYLSLSPW DKATLSMGRL VLSNKMARTI GFFYTLFLHC LVFLVLYKLA WSESMERDCA TFCAKKLADH LHKFHENDNG AAAGDLWQ //