ID Q13445_HUMAN PRELIMINARY; PRT; 227 AA. AC Q13445; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 07-FEB-2006, entry version 32. DE Putative T1/ST2 receptor binding protein precursor (Interleukin 1 DE receptor-like 1 ligand,) (Putative T1/ST2 receptor binding protein DE [Homo sapiens]). GN Name=TMED1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96215043; PubMed=8621446; DOI=10.1074/jbc.271.10.5784; RA Gayle M.A., Slack J.L., Bonnert T.P., Renshaw B.R., Sonoda G., RA Taguchi T., Testa J.R., Dower S.K., Sims J.E.; RT "Cloning of a putative ligand for the T1/ST2 receptor."; RL J. Biol. Chem. 271:5784-5789(1996). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skin; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [3] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skin; RG NIH MGC Project; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RA Lamerdin J.E., McCready P.M., Skowronski E., Richardson P., RA Burkhart-Schultz K., Gordon L., Dias J., Sakalsasis G., Stilwagen S., RA Phan H., Velasco N., Do L., Regala W., Terry A., Scott D., RA Danganan L., Erler A., Christensen M., Georgescu A., Avila J., RA Attix C., Andreise T., Trankheim M., Amico-Keller G., Coefield J., RA Duarte S., Lucas S., Bruce R., Thomas P., Quan G., Kronmiller B., RA Arellano A., Sanders C., Ow D., Nolan M., Trong S., Kobayashi A., RA Olsen A.S., Carrano A.V.; RT "Sequence analysis of a 3.9 Mb region in 19p13.2 between D19S391 and RT ZNF58."; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U41804; AAC50419.1; -; mRNA. DR EMBL; BC002443; AAH02443.1; -; mRNA. DR EMBL; AC007229; AAD23605.1; -; Genomic_DNA. DR Ensembl; ENSG00000099203; Homo sapiens. DR HGNC; HGNC:17291; TMED1. DR GO; GO:0005102; F:receptor binding; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000348; Emp24_gp25L_p24. DR InterPro; IPR009038; GOLD. DR Pfam; PF01105; EMP24_GP25L; 1. DR PROSITE; PS50866; GOLD; 1. KW Receptor; Signal; Transmembrane. FT SIGNAL 1 24 Potential. FT CHAIN 25 227 T1/ST2 receptor binding protein. SQ SEQUENCE 227 AA; 25206 MW; 058C5274E05F8575 CRC64; MMAAGAALAL ALWLLMPPVE VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA GDYKLCFDNS FSTISEKLVF FELIFDSLQD DEEVEGWAEA VEPEEMLDVK MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEGNL ERVNFWSAVN VAVLLLVAVL QVCTLKRFFQ DKRPVPT //