ID Q13445_HUMAN PRELIMINARY; PRT; 227 AA. AC Q13445; DT 01-NOV-1996 (TrEMBLrel. 01, Created) DT 01-NOV-1996 (TrEMBLrel. 01, Last sequence update) DT 10-MAY-2005 (TrEMBLrel. 30, Last annotation update) DE Putative T1/ST2 receptor binding protein (Interleukin 1 receptor-like DE 1 ligand,). GN Name=TMED1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=96215043; PubMed=8621446; DOI=10.1074/jbc.271.10.5784; RA Gayle M.A., Slack J.L., Bonnert T.P., Renshaw B.R., Sonoda G., RA Taguchi T., Testa J.R., Dower S.K., Sims J.E.; RT "Cloning of a putative ligand for the T1/ST2 receptor."; RL J. Biol. Chem. 271:5784-5789(1996). RN [2] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skin; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RG Mammalian Gene Collection Program Team; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., RA Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E., RA Jones S.J., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [3] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Skin; RA Director MGC Project; RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RA Lamerdin J.E., McCready P.M., Skowronski E., Richardson P., RA Burkhart-Schultz K., Gordon L., Dias J., Sakalsasis G., Stilwagen S., RA Phan H., Velasco N., Do L., Regala W., Terry A., Scott D., RA Danganan L., Erler A., Christensen M., Georgescu A., Avila J., RA Attix C., Andreise T., Trankheim M., Amico-Keller G., Coefield J., RA Duarte S., Lucas S., Bruce R., Thomas P., Quan G., Kronmiller B., RA Arellano A., Sanders C., Ow D., Nolan M., Trong S., Kobayashi A., RA Olsen A.S., Carrano A.V.; RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U41804; AAC50419.1; -; mRNA. DR EMBL; BC002443; AAH02443.1; -; mRNA. DR EMBL; AC007229; AAD23605.1; -; Genomic_DNA. DR Ensembl; ENSG00000099203; Homo sapiens. DR Genew; HGNC:17291; TMED1. DR GO; GO:0005515; F:protein binding; IPI. DR GO; GO:0005102; F:receptor binding; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR000348; Emp24_gp25L_p24. DR InterPro; IPR009038; GOLD. DR Pfam; PF01105; EMP24_GP25L; 1. DR PROSITE; PS50866; GOLD; 1. KW Receptor; Signal; Transmembrane. FT SIGNAL 1 24 Potential. FT CHAIN 25 227 T1/ST2 receptor binding protein. SQ SEQUENCE 227 AA; 25206 MW; 058C5274E05F8575 CRC64; MMAAGAALAL ALWLLMPPVE VGGAGPPPIQ DGEFTFLLPA GRKQCFYQSA PANASLETEY QVIGGAGLDV DFTLESPQGV LLVSESRKAD GVHTVEPTEA GDYKLCFDNS FSTISEKLVF FELIFDSLQD DEEVEGWAEA VEPEEMLDVK MEDIKESIET MRTRLERSIQ MLTLLRAFEA RDRNLQEGNL ERVNFWSAVN VAVLLLVAVL QVCTLKRFFQ DKRPVPT //