ID RED_HUMAN STANDARD; PRT; 557 AA. AC Q13123; DT 15-JUL-1999 (Rel. 38, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE RED PROTEIN (RER PROTEIN) (IK FACTOR) (CYTOKINE IK). GN RED OR RER OR IK. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=LEUKEMIA; RX MEDLINE; 99234094. RA Assier E., Bouzinba-Segard H., Stolzenberg M.-C., Stephens R., RA Bardos J., Freemont P., Charron D., Trowsdale J., Rich T.; RT "Isolation, sequencing and expression of RED, a novel human gene RT encoding an acidic-basic dipeptide repeat."; RL Gene 230:145-154(1999). RN [2] RP SEQUENCE OF 316-477 FROM N.A. RC TISSUE=LEUKEMIA; RX MEDLINE; 95060801. RA Krief P., Augery-Bourget Y., Plaisance S., Merck M.F., Assier E., RA Tanchou V., Billard M., Boucheix C., Jasmin C., Azzarone B.; RT "A new cytokine (IK) down-regulating HLA class II: monoclonal RT antibodies, cloning and chromosome localization."; RL Oncogene 9:3449-3456(1994). CC -!- FUNCTION: NOT KNOWN. MAY BIND TO CHROMATIN. CC -!- SUBCELLULAR LOCATION: NUCLEAR. CC -!- TISSUE SPECIFICITY: UBIQUITOUS. CC -!- DEVELOPMENTAL STAGE: EXPRESSED AT SIMILAR LEVELS IN FETAL AND CC ADULT TISSUES. CC -!- SIMILARITY: BELONGS TO THE RED FAMILY. CC -!- CAUTION: WAS ORIGINALLY THOUGHT TO BE THE IK FACTOR, A CYTOKINE CC INVOLVED IN THE NEGATIVE REGULATORY PATHWAY OF CONSTITUTIVE MHC CC CLASS II ANTIGENS EXPRESSION (REF.2). CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ005579; CAA06607.1; -. DR EMBL; S74221; AAB32531.1; -. DR MIM; 600549; -. KW Repeat. FT DOMAIN 184 187 POLY-GLU. FT DOMAIN 342 375 17 X 2 AA TANDEM REPEATS OF R-[ED]. SQ SEQUENCE 557 AA; 65630 MW; 09091E1FD4E4E5FD CRC64; MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRLEIAS KDKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE KRKKMEADGV EVKRPKY //