ID RED_HUMAN STANDARD; PRT; 557 AA. AC Q13123; DT 15-JUL-1999 (Rel. 38, Created) DT 30-MAY-2000 (Rel. 39, Last sequence update) DT 15-MAR-2004 (Rel. 43, Last annotation update) DE Red protein (RER protein) (IK factor) (Cytokine IK). GN IK OR RED OR RER. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Leukemia; RX MEDLINE=99234094; PubMed=10216252; RA Assier E., Bouzinba-Segard H., Stolzenberg M.-C., Stephens R., RA Bardos J., Freemont P., Charron D., Trowsdale J., Rich T.; RT "Isolation, sequencing and expression of RED, a novel human gene RT encoding an acidic-basic dipeptide repeat."; RL Gene 230:145-154(1999). RN [2] RP SEQUENCE OF 316-477 FROM N.A. RC TISSUE=Leukemia; RX MEDLINE=95060801; PubMed=7970704; RA Krief P., Augery-Bourget Y., Plaisance S., Merck M.F., Assier E., RA Tanchou V., Billard M., Boucheix C., Jasmin C., Azzarone B.; RT "A new cytokine (IK) down-regulating HLA class II: monoclonal RT antibodies, cloning and chromosome localization."; RL Oncogene 9:3449-3456(1994). CC -!- FUNCTION: Not known. May bind to chromatin. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- TISSUE SPECIFICITY: Ubiquitous. CC -!- DEVELOPMENTAL STAGE: Expressed at similar levels in fetal and CC adult tissues. CC -!- SIMILARITY: Belongs to the RED family. CC -!- CAUTION: Was originally (Ref.2) thought to be the IK factor, a CC cytokine involved in the negative regulatory pathway of CC constitutive MHC class II antigens expression. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ005579; CAA06607.1; -. DR EMBL; S74221; AAB32531.1; -. DR PIR; I58408; I58408. DR Genew; HGNC:5958; IK. DR MIM; 600549; -. DR GO; GO:0005615; C:extracellular space; TAS. DR GO; GO:0005625; C:soluble fraction; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0006955; P:immune response; TAS. KW Repeat. FT DOMAIN 184 187 Poly-Glu. FT DOMAIN 342 375 17 X 2 AA tandem repeats of R-[ED]. FT REPEAT 342 343 1. FT REPEAT 344 345 2. FT REPEAT 346 347 3. FT REPEAT 348 349 4. FT REPEAT 350 351 5. FT REPEAT 352 353 6. FT REPEAT 354 355 7. FT REPEAT 356 357 8. FT REPEAT 358 359 9. FT REPEAT 360 361 10. FT REPEAT 362 363 11. FT REPEAT 364 365 12. FT REPEAT 366 367 13. FT REPEAT 368 369 14. FT REPEAT 370 371 15. FT REPEAT 372 373 16. FT REPEAT 374 375 17. SQ SEQUENCE 557 AA; 65630 MW; 09091E1FD4E4E5FD CRC64; MPERDSEPFS NPLAPDGHDV DDPHSFHQSK LTNEDFRKLL MTPRAAPTSA PPSKSRHHEM PREYNEDEDP AARRRKKKSY YAKLRQQEIE RERELAEKYR DRAKERRDGV NKDYEETELI STTANYRAVG PTAEADKSAA EKRRQLIQES KFLGGDMEHT HLVKGLDFAL LQKVRLEIAS KDKEEEELME KPQKETKKDE DPENKIEFKT RLGRNVYRML FKSKAYERNE LFLPGRMAYV VDLDDEYADT DIPTTLIRSK ADCPTMEAQT TLTTNDIVIS KLTQILSYLR QGTRNKKLKK KDKGKLEEKK PPEADMNIFE DIGDYVPSTT KTPRDKERER YRERERDRER DRDRDRERER ERDRERERER DREREEEKKR HSYFEKPKVD DEPMDVDKGP GSTKELIKSI NEKFAGSAGW EGTESLKKPE DKKQLGDFFG MSNSYAECYP ATMDDMAVDS DEEVDYSKMD QGNKKGPLGR WDFDTQEEYS EYMNNKEALP KAAFQYGIKM SEGRKTRRFK ETNDKAELDR QWKKISAIIE KRKKMEADGV EVKRPKY //