ID TYPH_METBU Reviewed; 506 AA. AC Q12Z64; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2006, sequence version 1. DT 06-MAR-2013, entry version 47. DE RecName: Full=Putative thymidine phosphorylase; DE EC=2.4.2.4; DE AltName: Full=TdRPase; GN OrderedLocusNames=Mbur_0255; OS Methanococcoides burtonii (strain DSM 6242). OC Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; OC Methanosarcinaceae; Methanococcoides. OX NCBI_TaxID=259564; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 6242; RG US DOE Joint Genome Institute; RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., RA Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., RA Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., RA Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., RA Richardson P.; RT "Complete sequence of Methanococcoides burtonii DSM 6242."; RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Thymidine + phosphate = thymine + 2-deoxy- CC alpha-D-ribose 1-phosphate. CC -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside CC phosphorylase family. Type 2 subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000300; ABE51262.1; -; Genomic_DNA. DR RefSeq; YP_565012.1; NC_007955.1. DR ProteinModelPortal; Q12Z64; -. DR STRING; Q12Z64; -. DR GeneID; 3998750; -. DR GenomeReviews; CP000300_GR; Mbur_0255. DR KEGG; mbu:Mbur_0255; -. DR eggNOG; COG0213; -. DR HOGENOM; HOG000252767; -. DR KO; K00758; -. DR OMA; VHSIGGV; -. DR ProtClustDB; PRK04350; -. DR BioCyc; MBUR259564:GHBZ-318-MONOMER; -. DR GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro. DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro. DR GO; GO:0004645; F:phosphorylase activity; IEA:InterPro. DR GO; GO:0009032; F:thymidine phosphorylase activity; IEA:EC. DR GO; GO:0046125; P:pyrimidine deoxyribonucleoside metabolic process; IEA:InterPro. DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro. DR Gene3D; 2.40.40.20; -; 1. DR Gene3D; 3.40.1030.10; -; 1. DR Gene3D; 3.90.1170.30; -; 1. DR HAMAP; MF_00703; Thymid_phosp_2; 1; -. DR InterPro; IPR017713; AMP_phosphorylase. DR InterPro; IPR009010; Asp_de-COase-like_fold. DR InterPro; IPR000312; Glycosyl_Trfase_fam3. DR InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom. DR InterPro; IPR006657; MoPterin_dinucl-bd_dom. DR InterPro; IPR013102; PYNP_C. DR InterPro; IPR000053; Pyrmidine_PPase. DR InterPro; IPR017872; Pyrmidine_PPase_CS. DR InterPro; IPR013466; Thymidine_Pase_type2. DR PANTHER; PTHR10515; PTHR10515; 1. DR Pfam; PF02885; Glycos_trans_3N; 1. DR Pfam; PF00591; Glycos_transf_3; 1. DR Pfam; PF01568; Molydop_binding; 1. DR Pfam; PF07831; PYNP_C; 1. DR PIRSF; PIRSF000478; TP_PyNP; 1. DR SMART; SM00941; PYNP_C; 1. DR SUPFAM; SSF47648; Glyco_trans_3; 1. DR SUPFAM; SSF52418; Glyco_trans_3; 1. DR SUPFAM; SSF54680; PYNP_C; 1. DR TIGRFAMs; TIGR03327; AMP_phos; 1. DR TIGRFAMs; TIGR02645; ARCH_P_rylase; 1. DR PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1. PE 3: Inferred from homology; KW Complete proteome; Glycosyltransferase; Transferase. FT CHAIN 1 506 Putative thymidine phosphorylase. FT /FTId=PRO_0000314720. SQ SEQUENCE 506 AA; 55123 MW; A44D08052CF1DFDA CRC64; MQLKVQPIDV KVGKYKVILN TIDAKELGVH EGDRVRIKNH VTLTAIVDFT EDMISPGMIG LYHEVKEALS KEWTETVEVF PAEKPKSTYI IRKTMDGQKL TKEEIDILVK DIVEENLAEI EIAAFLTATY INDMTDDETE WLTRAMIDSG DKLEFDTHPI MDKHSIGGVP GNKISLLIVP IVAANGLLIP KTSSRAITGA GGTADLMEIL APVEFDAAEI KRMTEEVGGV LVWGGATNIA PADDKLIKVE YPLSIDPHCQ MLASIMAKKG AIGADHVVMD IPTGPGTKIK NVQEGRKLAR DLINLGDRLG MDVDCALTYG ASPVGRTIGP ALEVIEALKV LESFEGPNSL IEKSASLAGM LLEMGNVAGK DKGYDLAIET LKNGKALTKF KEIIKIQGGN PDVTHKDISV GEFTEDIIAP NNGYILEMDN KRLVQIARLA GAPNDKGAGI LLHRKQGEPL KEGDPVMTIY AEKKSKLENA VKSAKERPPF IVEGMMLERI QSFKEI //