ID TOP6B_METBU Reviewed; 622 AA. AC Q12WQ0; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2006, sequence version 1. DT 08-FEB-2011, entry version 33. DE RecName: Full=Type 2 DNA topoisomerase 6 subunit B; DE EC=5.99.1.3; DE AltName: Full=Type II DNA topoisomerase VI subunit B; DE Short=TopoVI-B; GN Name=top6B; OrderedLocusNames=Mbur_1203; OS Methanococcoides burtonii (strain DSM 6242). OC Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; OC Methanosarcinaceae; Methanococcoides. OX NCBI_TaxID=259564; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 6242; RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., RA Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., RA Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., RA Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., RA Richardson P.; RT "Complete sequence of Methanococcoides burtonii DSM 6242."; RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Relaxes both positive and negative superturns and CC exhibits a strong decatenase activity. The B subunit binds ATP (By CC similarity). CC -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining CC of double-stranded DNA. CC -!- SUBUNIT: Heterotetramer of two subunits A and two subunits B (By CC similarity). CC -!- SIMILARITY: Belongs to the TOP6B family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000300; ABE52126.1; -; Genomic_DNA. DR RefSeq; YP_565876.1; NC_007955.1. DR ProteinModelPortal; Q12WQ0; -. DR SMR; Q12WQ0; 11-606. DR STRING; Q12WQ0; -. DR GeneID; 3998359; -. DR GenomeReviews; CP000300_GR; Mbur_1203. DR KEGG; mbu:Mbur_1203; -. DR NMPDR; fig|259564.8.peg.1139; -. DR eggNOG; arNOG04571; -. DR HOGENOM; HBG733142; -. DR OMA; YTSAGKQ; -. DR ProtClustDB; PRK04184; -. DR BioCyc; MBUR259564:MBUR_1203-MONOMER; -. DR GO; GO:0005694; C:chromosome; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC. DR GO; GO:0006265; P:DNA topological change; IEA:InterPro. DR HAMAP; MF_00322; Top6B; 1; -. DR InterPro; IPR003594; ATPase-like_ATP-bd. DR InterPro; IPR010979; Ribosomal_S13-like_H2TH. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr. DR InterPro; IPR005734; TopoVI_B. DR InterPro; IPR015320; TopoVI_B_transducer. DR Gene3D; G3DSA:3.30.565.10; ATP_bd_ATPase; 1. DR Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1. DR Pfam; PF02518; HATPase_c; 1. DR Pfam; PF09239; Topo-VIb_trans; 1. DR PIRSF; PIRSF006553; TopoVI_B; 1. DR ProDom; PD013790; TopoVI_B_transducer; 1. DR SMART; SM00387; HATPase_c; 1. DR SUPFAM; SSF55874; ATP_bd_ATPase; 1. DR SUPFAM; SSF46946; Ribosomal_H2TH; 1. DR SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1. DR TIGRFAMs; TIGR01052; top6b; 1. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; DNA-binding; Isomerase; KW Nucleotide-binding; Topoisomerase. FT CHAIN 1 622 Type 2 DNA topoisomerase 6 subunit B. FT /FTId=PRO_1000005871. SQ SEQUENCE 622 AA; 68876 MW; 701F62BAE803127A CRC64; MAAPIAEELA KKQQAISVAE FFEKNRQILG FDSAPRSLIT TVKEAVDNSL DACEEAEILP DILLHIERVG KDNVSVIVED NGPGIVKEQI PKVFAKLLYG SRFHALKQSR GQQGIGISAS VLYAQLTAGH PTSVISKIGP DSPAHHYEVM INTSTNDPEI LLDEVIDWDR PHGTRVELEM EASYVKGRRQ SIYEYLKATA IVNPHARLTL IEPDGNEVIF DRATDKLPIP AKEILPHPHG IELGTLMKML RYTDRQKLAP FLRYSFSKIG LLTAEEICKA AGLDTEMLPS KLTRDQTKKL LDAFKKVKIM APPTDCLSPI GEELIYKGLE KEFNVDFIAT TTRSPSVFSG NPFVVEVGIA YGGVLQKDDR IDIMRFANRV PLLYQQGGCA TTHAVEGIKW KQYGLNQPGG GMPTGPVVLL VHVASTNVPF TSESKDAIAD IPEIRDEVEL AIKEVSRKLN RYLNRQVSLK KRREKEIIIT KVLPKMAQKL ADTLERDLPD INPVVAKVMG NLLVMRHVEH GANGDAAVTI KVKNFGSKLT EFKLHDMLPY EISDVSPEPK VISMGSDFDY VWTMKVSPEG SKAVTYSLSS MSEDEIKRLP QLIVEGLDEE LVTGAKAIKG LI //