ID AROE_METBU Reviewed; 269 AA. AC Q12UJ9; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2006, sequence version 1. DT 18-APR-2012, entry version 52. DE RecName: Full=Shikimate dehydrogenase; DE EC=1.1.1.25; GN Name=aroE; OrderedLocusNames=Mbur_1998; OS Methanococcoides burtonii (strain DSM 6242). OC Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; OC Methanosarcinaceae; Methanococcoides. OX NCBI_TaxID=259564; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 6242; RG US DOE Joint Genome Institute; RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., RA Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., RA Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., RA Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., RA Richardson P.; RT "Complete sequence of Methanococcoides burtonii DSM 6242."; RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate + CC NADPH. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate CC biosynthesis; chorismate from D-erythrose 4-phosphate and CC phosphoenolpyruvate: step 4/7. CC -!- SIMILARITY: Belongs to the shikimate dehydrogenase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000300; ABE52877.1; -; Genomic_DNA. DR RefSeq; YP_566627.1; NC_007955.1. DR ProteinModelPortal; Q12UJ9; -. DR STRING; Q12UJ9; -. DR GeneID; 3996950; -. DR GenomeReviews; CP000300_GR; Mbur_1998. DR KEGG; mbu:Mbur_1998; -. DR eggNOG; COG0169; -. DR HOGENOM; HBG553408; -. DR KO; K00014; -. DR OMA; PAMHTAS; -. DR ProtClustDB; CLSK812084; -. DR BioCyc; MBUR259564:MBUR_1998-MONOMER; -. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR GO; GO:0004764; F:shikimate 3-dehydrogenase (NADP+) activity; IEA:EC. DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR HAMAP; MF_00222; Shikimate_DH_AroE; 1; -. DR InterPro; IPR016040; NAD(P)-bd_dom. DR InterPro; IPR011342; Shikimate_DH. DR InterPro; IPR013708; Shikimate_DH-bd_N. DR InterPro; IPR022893; Shikimate_quinate_DH. DR InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase. DR Pfam; PF01488; Shikimate_DH; 1. DR Pfam; PF08501; Shikimate_dh_N; 1. DR TIGRFAMs; TIGR00507; AroE; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; KW Complete proteome; NADP; Oxidoreductase. FT CHAIN 1 269 Shikimate dehydrogenase. FT /FTId=PRO_1000021302. FT NP_BIND 124 128 NADP (By similarity). FT ACT_SITE 66 66 Proton acceptor (Potential). SQ SEQUENCE 269 AA; 28790 MW; B5A787654C8B454A CRC64; MKKIFAVLGD PIEHSLSPIM HNSAFEALDM DCTYHAFRVE KNDLENALQG AKAMGFGGLN LTVPLKETAL KFVDADSLAA KIGAINTIDF KDGIKGYNTD GIGAKRTIED EGVDIKDKNV LILGAGGAAR AIAFTFAEAG ANVNIANRTP ERAMQLAAEI GDAKGYGLDI VDNGLEDIDI LINTTTVGLG NSNGTLVTAE QMHSDLAVFD IVYNPLMTKL LQEAETAGAR PITGIMMLVY QGAEAFRIWT GKEPPINVMK KTVMETLDI //