ID Q12UJ9_METBU Unreviewed; 269 AA. AC Q12UJ9; DT 22-AUG-2006, integrated into UniProtKB/TrEMBL. DT 22-AUG-2006, sequence version 1. DT 13-NOV-2007, entry version 13. DE Shikimate 5-dehydrogenase (EC 1.1.1.25). GN OrderedLocusNames=Mbur_1998; OS Methanococcoides burtonii (strain DSM 6242). OC Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; OC Methanosarcinaceae; Methanococcoides. OX NCBI_TaxID=259564; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., RA Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., RA Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., RA Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., RA Richardson P.; RT "Complete sequence of Methanococcoides burtonii DSM 6242."; RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate + CC NADPH. CC -!- PATHWAY: Context: Aromatic amino acids biosynthesis. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate CC biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: CC step 4/7. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000300; ABE52877.1; -; Genomic_DNA. DR RefSeq; YP_566627.1; -. DR GeneID; 3996950; -. DR GenomeReviews; CP000300_GR; Mbur_1998. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:InterPro. DR GO; GO:0016089; P:aromatic amino acid family biosynthetic pro...; IEA:InterPro. DR InterPro; IPR011342; Quinate_shikimate_5-DH. DR InterPro; IPR006151; Shikimate_DH/Glu-tRNA_Rdtase. DR InterPro; IPR013708; Shikimate_DH_N. DR Pfam; PF01488; Shikimate_DH; 1. DR Pfam; PF08501; Shikimate_dh_N; 1. DR TIGRFAMs; TIGR00507; aroE; 1. PE 4: Predicted; KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; KW Complete proteome; NADP; Oxidoreductase. SQ SEQUENCE 269 AA; 28790 MW; B5A787654C8B454A CRC64; MKKIFAVLGD PIEHSLSPIM HNSAFEALDM DCTYHAFRVE KNDLENALQG AKAMGFGGLN LTVPLKETAL KFVDADSLAA KIGAINTIDF KDGIKGYNTD GIGAKRTIED EGVDIKDKNV LILGAGGAAR AIAFTFAEAG ANVNIANRTP ERAMQLAAEI GDAKGYGLDI VDNGLEDIDI LINTTTVGLG NSNGTLVTAE QMHSDLAVFD IVYNPLMTKL LQEAETAGAR PITGIMMLVY QGAEAFRIWT GKEPPINVMK KTVMETLDI //