ID   FALZ_HUMAN     STANDARD;      PRT;   810 AA.
AC   Q12830;
DT   15-JUL-1999 (Rel. 38, Created)
DT   15-JUL-1999 (Rel. 38, Last sequence update)
DT   16-OCT-2001 (Rel. 40, Last annotation update)
DE   Fetal alzheimer antigen (Fetal Alz-50-reactive clone 1).
GN   FALZ OR FAC1.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Fetal brain;
RX   MEDLINE=95347245; PubMed=7621746;
RA   Bowser R., Giambrone A., Davies P.;
RT   "FAC1, a novel gene identified with the monoclonal antibody Alz50,
RT   is developmentally regulated in human brain.";
RL   Dev. Neurosci. 17:20-37(1995).
CC   -!- SUBCELLULAR LOCATION: DETECTED IN BOTH THE CYTOPLASM AND NUCLEUS
CC       OF CELLS IN THE DEVELOPING CORTEX. IN THE ADULT BRAIN, IT WAS SEEN
CC       ALMOST EXCLUSIVELY IN THE NUCLEI OF NEURONS OF THE NEOCORTEX. IN
CC       THE BRAINS OF ALZHEIMER DISEASE PATIENTS, THE PROTEIN IS LOCALIZED
CC       IN A SUBSET OF AMYLOID-CONTAINING PLAQUES.
CC   -!- TISSUE SPECIFICITY: ABUNDANTLY EXPRESSED IN THE FETAL BRAIN.
CC       EXPRESSION IS MUCH LOWER IN ADULT BRAIN AND IS HIGHER IN
CC       NEURODEGENERATIVE DISEASES.
CC   -!- SIMILARITY: CONTAINS 1 PHD-TYPE ZINC FINGER.
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DR   EMBL; U05237; AAA97522.1; -.
DR   MIM; 601819; -.
DR   InterPro; IPR004022; DDT.
DR   InterPro; IPR001965; PHD.
DR   Pfam; PF00628; PHD; 1.
DR   Pfam; PF02791; DDT; 1.
DR   SMART; SM00249; PHD; 1.
KW   Nuclear protein; Zinc-finger.
FT   ZN_FING     251    298       PHD-TYPE.
FT   DOMAIN        4      9       POLY-GLU.
FT   DOMAIN       30     35       POLY-ASP.
FT   DOMAIN       42     46       POLY-ASP.
FT   DOMAIN      657    660       POLY-ALA.
SQ   SEQUENCE   810 AA;  91799 MW;  F7E2C992FE5BE96D CRC64;
     MVSEEEEEED GDAEETQDSE DDEEDEMEED DDDSDYPEEM EDDDDDASYC TESSFRSHST
     YSSTPGRRKP RVHRPRSPIL EEKDIPPLEF PKSSEDLMVP NEHIMNVIAI YEVLRNFGTV
     LRLSPFRFED FCAALVSQEQ CTLMAEMHVV LLKAVLREED TSNTTFGPAD LKDSVNSTLY
     FIDGMTWPEV LRVYCESDKE YHHVLPYQEA EDYPYGPVEN KIKVLQFLVD QFLTTNIARE
     ELMSEGVIQY DDHCRVCHKL GDLLCCETCS AVYHLECVKP PLEEVPEDEW QCEVCVAHKV
     PGVTDCVAEI QKNKPYIRHE PIGYDRSRRK YWFLNRRLII EEDTENENEK KIWYYSTKVQ
     LAELIDCLDK DYWEAELCKI LEEMREEIHR HMDITEDLTN KARGSNKSFL AAANEEILES
     IRAKKGDIDN VKSPEETEKD KNETENDSKD AEKNREEFED QSLEKDSDDK TPDDDPEQGK
     SEEPTEVGDK GNSVSANLGD NTTNATSEET SPSEGRSPVG CLSETPDSSN MAEKKVASEL
     PQDVPEEPNK TCESSNTSAT TTSIQPNLEN SNSSSELNSS QSESAKAADD PENGERESHT
     PVSIQEEIVG DFTSEKSTGE LSESPGAGKG ASGSTRIITR LRNPDSKLSQ LKSQQVAAAA
     HEANKLFKEG KEVLVVNSQG EISRLSTKKE VIMKGNINNY FKLGQEGKYR VYHNQYSTNS
     FALNKHQHRE DHDKRRHLAH KFCLTPAGEF KWNGSVHGSK VLTISTLRLT ITQLETTSLH
     PSFIPTGHHI GQIGSRQFRC VANPENLHWL
//