ID CEP76_MOUSE Reviewed; 659 AA. AC Q0VEJ0; DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot. DT 05-SEP-2006, sequence version 1. DT 13-SEP-2023, entry version 108. DE RecName: Full=Centrosomal protein of 76 kDa; DE Short=Cep76; GN Name=Cep76; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND SER-83, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Brain, and Lung; RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). CC -!- FUNCTION: Centrosomal protein involved in regulation of centriole CC duplication. Required to limit centriole duplication to once per cell CC cycle by preventing centriole reduplication (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with CCP110 and CEP97. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing CC center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule CC organizing center, centrosome, centriole {ECO:0000250}. Note=Does not CC localize along the ciliary axoneme. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the CEP76 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH466528; EDL09636.1; -; Genomic_DNA. DR EMBL; BC119216; AAI19217.1; -; mRNA. DR EMBL; BC119218; AAI19219.1; -; mRNA. DR CCDS; CCDS37850.1; -. DR RefSeq; NP_001074542.1; NM_001081073.1. DR AlphaFoldDB; Q0VEJ0; -. DR SMR; Q0VEJ0; -. DR BioGRID; 230419; 48. DR IntAct; Q0VEJ0; 19. DR STRING; 10090.ENSMUSP00000095149; -. DR iPTMnet; Q0VEJ0; -. DR PhosphoSitePlus; Q0VEJ0; -. DR SwissPalm; Q0VEJ0; -. DR EPD; Q0VEJ0; -. DR jPOST; Q0VEJ0; -. DR MaxQB; Q0VEJ0; -. DR PaxDb; Q0VEJ0; -. DR PeptideAtlas; Q0VEJ0; -. DR ProteomicsDB; 280071; -. DR Antibodypedia; 21948; 169 antibodies from 23 providers. DR Ensembl; ENSMUST00000097542; ENSMUSP00000095149; ENSMUSG00000073542. DR GeneID; 225659; -. DR KEGG; mmu:225659; -. DR UCSC; uc008fmq.1; mouse. DR AGR; MGI:1923401; -. DR CTD; 79959; -. DR MGI; MGI:1923401; Cep76. DR VEuPathDB; HostDB:ENSMUSG00000073542; -. DR eggNOG; ENOG502QQEI; Eukaryota. DR GeneTree; ENSGT00390000000781; -. DR HOGENOM; CLU_027144_0_0_1; -. DR InParanoid; Q0VEJ0; -. DR OMA; SFFANCQ; -. DR OrthoDB; 315381at2759; -. DR PhylomeDB; Q0VEJ0; -. DR TreeFam; TF329324; -. DR Reactome; R-MMU-2565942; Regulation of PLK1 Activity at G2/M Transition. DR Reactome; R-MMU-380259; Loss of Nlp from mitotic centrosomes. DR Reactome; R-MMU-380270; Recruitment of mitotic centrosome proteins and complexes. DR Reactome; R-MMU-380284; Loss of proteins required for interphase microtubule organization from the centrosome. DR Reactome; R-MMU-380320; Recruitment of NuMA to mitotic centrosomes. DR Reactome; R-MMU-5620912; Anchoring of the basal body to the plasma membrane. DR Reactome; R-MMU-8854518; AURKA Activation by TPX2. DR BioGRID-ORCS; 225659; 5 hits in 78 CRISPR screens. DR ChiTaRS; Cep76; mouse. DR PRO; PR:Q0VEJ0; -. DR Proteomes; UP000000589; Chromosome 18. DR RNAct; Q0VEJ0; Protein. DR Bgee; ENSMUSG00000073542; Expressed in spermatocyte and 212 other tissues. DR Genevisible; Q0VEJ0; MM. DR GO; GO:0005814; C:centriole; ISS:UniProtKB. DR GO; GO:0005813; C:centrosome; ISO:MGI. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0032991; C:protein-containing complex; ISO:MGI. DR GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB. DR Gene3D; 3.10.620.30; -; 1. DR InterPro; IPR028926; CEP76-C2. DR InterPro; IPR038765; Papain-like_cys_pep_sf. DR PANTHER; PTHR46436; CENTROSOMAL PROTEIN OF 76 KDA; 1. DR PANTHER; PTHR46436:SF1; CENTROSOMAL PROTEIN OF 76 KDA; 1. DR Pfam; PF15627; CEP76-C2; 1. DR SUPFAM; SSF54001; Cysteine proteinases; 1. PE 1: Evidence at protein level; KW Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome. FT CHAIN 1..659 FT /note="Centrosomal protein of 76 kDa" FT /id="PRO_0000378949" FT MOD_RES 75 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" FT MOD_RES 83 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:21183079" SQ SEQUENCE 659 AA; 74303 MW; 658CF10C0C3A74B5 CRC64; MSLPPEKASE LKQLIHQQLS KMDVHGRIRE ILAETIREEL APDQQHLSTE DLIKALRRRG IIDDVMKELN FVTDSVDQEL PSSPKQTVGF DKQSTLKKTN VDPTRRYLYL QVLGGKAFLE HLQEPEPLPG QICSTFTLCL HYRNQRFRSK PVPCACEPDF HDGFLLEVHR ESLGDGTRMA DSTTMLSISD PIHMVLIKTD IFGETTLVAS YFLEWRSVLG SENGVTNLTV ELMGVGTESK VSVGILNIKL EMYPPLSQTL SQEVVNTQLA LERQKTAEKE RLFLVYAKQW WREYLQIRPS HNSRLVKIFA QDENGINRPV CSYVKPLRAG RLLDTPRQAA RFVNVLGYER APVIGGGGKQ EQWCTLLAFL CRNKGDCEDH ANLLCSLLLG YGLEAFVCVG TKAKGAPHAW VMTCGTDGTI MFWESLTGHR YIHKPTNPDG PPLAEQPKPL YPYRTIGCVF NHQMFLGNCQ PSDAVETCIF DLNDESKWKP MSEEAIKSVC APGATTSLPP FPPLCASTID ASVTSNEIEM QLRLLVSEHR KDLGLTTVWE DQLSYLLSPA LASYEFERTT SISAGNEEFQ DAIRRAVPDG HTFKGFPIHF VYRNARRAFA TCLRSPFCEE IICCRGDQVR LAVRVRVFTY PESACAVWIM FACKYRSVL //