ID Q0VCQ6_BOVIN Unreviewed; 212 AA. AC Q0VCQ6; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 05-SEP-2006, sequence version 1. DT 29-MAY-2024, entry version 126. DE SubName: Full=Programmed cell death 10 {ECO:0000313|EMBL:AAI20053.1, ECO:0000313|Ensembl:ENSBTAP00000042398.1}; GN Name=PDCD10 {ECO:0000313|EMBL:AAI20053.1, GN ECO:0000313|Ensembl:ENSBTAP00000042398.1, GN ECO:0000313|VGNC:VGNC:32658}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI20053.1}; RN [1] {ECO:0000313|EMBL:AAI20053.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Hereford {ECO:0000313|EMBL:AAI20053.1}; RC TISSUE=Fetal cerebellum {ECO:0000313|EMBL:AAI20053.1}; RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y., RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C., RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J., RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J., RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A., RA Holt R., Jones S.J., Marra M.A.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSBTAP00000042398.1, ECO:0000313|Proteomes:UP000009136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000042398.1, RC ECO:0000313|Proteomes:UP000009136}; RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A., RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C., RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.; RT "ARS-UCD1.2."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSBTAP00000042398.1} RP IDENTIFICATION. RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000042398.1}; RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413}; CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413}; CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasm CC {ECO:0000256|ARBA:ARBA00004496}. Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004255}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004255}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004255}. Membrane CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side CC {ECO:0000256|ARBA:ARBA00004287}. CC -!- SIMILARITY: Belongs to the PDCD10 family. CC {ECO:0000256|ARBA:ARBA00009181}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC120052; AAI20053.1; -; mRNA. DR RefSeq; NP_001068727.1; NM_001075259.1. DR RefSeq; XP_005201773.1; XM_005201716.3. DR RefSeq; XP_005201774.1; XM_005201717.3. DR STRING; 9913.ENSBTAP00000066778; -. DR PaxDb; 9913-ENSBTAP00000042398; -. DR Ensembl; ENSBTAT00000044960.2; ENSBTAP00000042398.1; ENSBTAG00000031709.3. DR GeneID; 506411; -. DR KEGG; bta:506411; -. DR CTD; 11235; -. DR VEuPathDB; HostDB:ENSBTAG00000031709; -. DR VGNC; VGNC:32658; PDCD10. DR eggNOG; KOG4025; Eukaryota. DR GeneTree; ENSGT00390000017913; -. DR HOGENOM; CLU_083906_1_0_1; -. DR OMA; HVVLFPI; -. DR OrthoDB; 3801237at2759; -. DR TreeFam; TF105802; -. DR Proteomes; UP000009136; Chromosome 1. DR Bgee; ENSBTAG00000031709; Expressed in milk and 109 other cell types or tissues. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IBA:GO_Central. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl. DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central. DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW. DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl. DR GO; GO:0051683; P:establishment of Golgi localization; IEA:Ensembl. DR GO; GO:0090168; P:Golgi reassembly; IEA:Ensembl. DR GO; GO:0036481; P:intrinsic apoptotic signaling pathway in response to hydrogen peroxide; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:1903588; P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IEA:Ensembl. DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl. DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl. DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0090316; P:positive regulation of intracellular protein transport; IEA:Ensembl. DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Ensembl. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; IEA:Ensembl. DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl. DR GO; GO:1903358; P:regulation of Golgi organization; IBA:GO_Central. DR GO; GO:0044319; P:wound healing, spreading of cells; IEA:Ensembl. DR Gene3D; 1.10.12.70; -; 1. DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1. DR InterPro; IPR046409; PDC10_dimerisation_sf. DR InterPro; IPR009652; PDCD10. DR InterPro; IPR048288; PDCD10_N. DR PANTHER; PTHR13250:SF1; PROGRAMMED CELL DEATH PROTEIN 10; 1. DR PANTHER; PTHR13250; TF-1 CELL APOPTOSIS RELATED PROTEIN-15; 1. DR Pfam; PF06840; PDC10_C; 1. DR Pfam; PF20929; PDCD10_N; 1. PE 2: Evidence at transcript level; KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657}; KW Apoptosis {ECO:0000256|ARBA:ARBA00022703}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Reference proteome {ECO:0000313|Proteomes:UP000009136}. FT DOMAIN 15..72 FT /note="Programmed cell death protein 10 dimerisation" FT /evidence="ECO:0000259|Pfam:PF20929" SQ SEQUENCE 212 AA; 24716 MW; 5AA613F709C63F56 CRC64; MRMTMEEMKN EAETTSMVSM PLYAVMYPVF NELERVNLSA AQTLRAAFIK AEKENPGLTQ DIIMKILEKK SVEVNFTESL LRMAADDVEE YMIERPEPEF QDLNEKARAL KQILSKIPDE INDRVRFLQT IKDIASAIKE LLDTVNNVFK KYQYQNRRAL EHQKKEFVKY SKSFSDTLKT YFKDGKAINV FISANRLIHQ TNLILQTFKT VA //