ID Q0VB73_MOUSE Unreviewed; 208 AA. AC Q0VB73; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 05-SEP-2006, sequence version 1. DT 27-MAR-2024, entry version 133. DE RecName: Full=Granulocyte colony-stimulating factor {ECO:0000256|ARBA:ARBA00019452}; GN Name=Csf3 {ECO:0000313|EMBL:AAI20762.1, ECO:0000313|MGI:MGI:1339751}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI20762.1}; RN [1] {ECO:0000313|EMBL:AAI20762.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI20762.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are CC cytokines that act in hematopoiesis by controlling the production, CC differentiation, and function of 2 related white cell populations of CC the blood, the granulocytes and the monocytes-macrophages. This CSF CC induces granulocytes. {ECO:0000256|ARBA:ARBA00024794}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the IL-6 superfamily. CC {ECO:0000256|ARBA:ARBA00007432}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC120759; AAI20760.1; -; mRNA. DR EMBL; BC120761; AAI20762.1; -; mRNA. DR RefSeq; NP_034101.1; NM_009971.1. DR AlphaFoldDB; Q0VB73; -. DR SMR; Q0VB73; -. DR Antibodypedia; 799; 1455 antibodies from 40 providers. DR DNASU; 12985; -. DR GeneID; 12985; -. DR KEGG; mmu:12985; -. DR AGR; MGI:1339751; -. DR CTD; 1440; -. DR MGI; MGI:1339751; Csf3. DR VEuPathDB; HostDB:ENSMUSG00000038067; -. DR HOGENOM; CLU_118367_0_0_1; -. DR OMA; APLEQCH; -. DR OrthoDB; 4636828at2759; -. DR BioGRID-ORCS; 12985; 4 hits in 80 CRISPR screens. DR ExpressionAtlas; Q0VB73; baseline and differential. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl. DR GO; GO:0008083; F:growth factor activity; IEA:Ensembl. DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl. DR GO; GO:0038158; P:granulocyte colony-stimulating factor signaling pathway; IEA:Ensembl. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:InterPro. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl. DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR040117; GCSF/MGF. DR InterPro; IPR030474; IL-6/GCSF/MGF. DR InterPro; IPR030473; IL6/GCSF/MGF_CS. DR PANTHER; PTHR10511; GRANULOCYTE COLONY-STIMULATING FACTOR; 1. DR PANTHER; PTHR10511:SF2; GRANULOCYTE COLONY-STIMULATING FACTOR; 1. DR Pfam; PF16647; GCSF; 1. DR PIRSF; PIRSF001935; IL6_MGF_GCSF; 1. DR PRINTS; PR00433; IL6GCSFMGF. DR SMART; SM00126; IL6; 1. DR SUPFAM; SSF47266; 4-helical cytokines; 1. DR PROSITE; PS00254; INTERLEUKIN_6; 1. PE 2: Evidence at transcript level; KW Cytokine {ECO:0000256|ARBA:ARBA00022514}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, KW ECO:0000256|PIRSR:PIRSR001935-1}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..30 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 31..208 FT /note="Granulocyte colony-stimulating factor" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014306831" FT DISULFID 72..78 FT /evidence="ECO:0000256|PIRSR:PIRSR001935-1" FT DISULFID 100..110 FT /evidence="ECO:0000256|PIRSR:PIRSR001935-1" SQ SEQUENCE 208 AA; 22421 MW; 0BF3622135C906DB CRC64; MAQLSAQRRM KLMALQLLLW QSALWSGREA VPLVTVSALP PSLPLPRSFL LKSLEQVRKI QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC SSQALQQTQC LSQLHSGLCL YQGLLQALSG ISPALAPTLD LLQLDVANFA TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF QRRAGGVLAI SYLQGFLETA RLALHHLA //