ID   Q0VB73_MOUSE            Unreviewed;       208 AA.
AC   Q0VB73;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   13-SEP-2023, entry version 130.
DE   RecName: Full=Granulocyte colony-stimulating factor {ECO:0000256|ARBA:ARBA00019452};
GN   Name=Csf3 {ECO:0000313|EMBL:AAI20762.1, ECO:0000313|MGI:MGI:1339751};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI20762.1};
RN   [1] {ECO:0000313|EMBL:AAI20762.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI20762.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages. This CSF
CC       induces granulocytes. {ECO:0000256|ARBA:ARBA00024794}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC       {ECO:0000256|ARBA:ARBA00007432}.
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DR   EMBL; BC120759; AAI20760.1; -; mRNA.
DR   EMBL; BC120761; AAI20762.1; -; mRNA.
DR   RefSeq; NP_034101.1; NM_009971.1.
DR   AlphaFoldDB; Q0VB73; -.
DR   SMR; Q0VB73; -.
DR   Antibodypedia; 799; 1418 antibodies from 40 providers.
DR   DNASU; 12985; -.
DR   GeneID; 12985; -.
DR   KEGG; mmu:12985; -.
DR   AGR; MGI:1339751; -.
DR   CTD; 1440; -.
DR   MGI; MGI:1339751; Csf3.
DR   VEuPathDB; HostDB:ENSMUSG00000038067; -.
DR   HOGENOM; CLU_118367_0_0_1; -.
DR   OMA; APLEQCH; -.
DR   OrthoDB; 4636828at2759; -.
DR   BioGRID-ORCS; 12985; 4 hits in 80 CRISPR screens.
DR   ExpressionAtlas; Q0VB73; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:1901215; P:negative regulation of neuron death; IEA:Ensembl.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:InterPro.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
DR   GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR040117; GCSF/MGF.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR   PANTHER; PTHR10511:SF2; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR   Pfam; PF16647; GCSF; 1.
DR   PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   2: Evidence at transcript level;
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR001935-1};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..208
FT                   /note="Granulocyte colony-stimulating factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014306831"
FT   DISULFID        72..78
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001935-1"
FT   DISULFID        100..110
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001935-1"
SQ   SEQUENCE   208 AA;  22421 MW;  0BF3622135C906DB CRC64;
     MAQLSAQRRM KLMALQLLLW QSALWSGREA VPLVTVSALP PSLPLPRSFL LKSLEQVRKI
     QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC SSQALQQTQC LSQLHSGLCL
     YQGLLQALSG ISPALAPTLD LLQLDVANFA TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF
     QRRAGGVLAI SYLQGFLETA RLALHHLA
//