ID Q0VB73_MOUSE Unreviewed; 208 AA. AC Q0VB73; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 05-SEP-2006, sequence version 1. DT 02-DEC-2020, entry version 117. DE RecName: Full=Granulocyte colony-stimulating factor {ECO:0000256|ARBA:ARBA00019452}; GN Name=Csf3 {ECO:0000313|EMBL:AAI20762.1, ECO:0000313|MGI:MGI:1339751}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAI20762.1}; RN [1] {ECO:0000313|EMBL:AAI20762.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain {ECO:0000313|EMBL:AAI20762.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the IL-6 superfamily. CC {ECO:0000256|ARBA:ARBA00007432}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC120759; AAI20760.1; -; mRNA. DR EMBL; BC120761; AAI20762.1; -; mRNA. DR RefSeq; NP_034101.1; NM_009971.1. DR SMR; Q0VB73; -. DR Antibodypedia; 799; 1251 antibodies. DR GeneID; 12985; -. DR KEGG; mmu:12985; -. DR CTD; 1440; -. DR MGI; MGI:1339751; Csf3. DR HOGENOM; CLU_118367_0_0_1; -. DR OMA; TVWQQME; -. DR OrthoDB; 1289639at2759; -. DR BioGRID-ORCS; 12985; 2 hits in 19 CRISPR screens. DR Bgee; ENSMUSG00000038067; Expressed in adult mammalian kidney and 54 other tissues. DR ExpressionAtlas; Q0VB73; baseline and differential. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0071345; P:cellular response to cytokine stimulus; IEA:Ensembl. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl. DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl. DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl. DR GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:InterPro. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl. DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl. DR GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl. DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR040117; GCSF/MGF. DR InterPro; IPR030474; IL-6/GCSF/MGF. DR InterPro; IPR030473; IL6/GCSF/MGF_CS. DR PANTHER; PTHR10511; PTHR10511; 1. DR Pfam; PF16647; GCSF; 1. DR PIRSF; PIRSF001935; IL6_MGF_GCSF; 1. DR PRINTS; PR00433; IL6GCSFMGF. DR SMART; SM00126; IL6; 1. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00254; INTERLEUKIN_6; 1. PE 2: Evidence at transcript level; KW Cytokine {ECO:0000256|ARBA:ARBA00022514}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001935-1}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Growth factor {ECO:0000256|ARBA:ARBA00023030}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..30 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 31..208 FT /note="Granulocyte colony-stimulating factor" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014306831" FT DISULFID 72..78 FT /evidence="ECO:0000256|PIRSR:PIRSR001935-1" FT DISULFID 100..110 FT /evidence="ECO:0000256|PIRSR:PIRSR001935-1" SQ SEQUENCE 208 AA; 22421 MW; 0BF3622135C906DB CRC64; MAQLSAQRRM KLMALQLLLW QSALWSGREA VPLVTVSALP PSLPLPRSFL LKSLEQVRKI QASGSVLLEQ LCATYKLCHP EELVLLGHSL GIPKASLSGC SSQALQQTQC LSQLHSGLCL YQGLLQALSG ISPALAPTLD LLQLDVANFA TTIWQQMENL GVAPTVQPTQ SAMPAFTSAF QRRAGGVLAI SYLQGFLETA RLALHHLA //