ID Q0PGS4_MOUSE Unreviewed; 149 AA. AC Q0PGS4; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 05-SEP-2006, sequence version 1. DT 27-MAR-2024, entry version 73. DE RecName: Full=Interleukin-2 {ECO:0000256|ARBA:ARBA00019453, ECO:0000256|RuleBase:RU363134}; DE Short=IL-2 {ECO:0000256|RuleBase:RU363134}; DE Flags: Fragment; GN Name=Il2 {ECO:0000313|MGI:MGI:96548}; GN Synonyms=IL2 {ECO:0000256|RuleBase:RU363134}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABH04319.1}; RN [1] {ECO:0000313|EMBL:ABH04319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:ABH04319.1}; RA Chantajorn S., Hongprayoon R., Songserm T.; RT "Cloning, expression and purification of mouse interleukin 2 and its RT biological activity."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytokine produced by activated CD4-positive helper T-cells CC and to a lesser extend activated CD8-positive T-cells and natural CC killer (NK) cells that plays pivotal roles in the immune response and CC tolerance. Binds to a receptor complex composed of either the high- CC affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or CC the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the CC receptor leads to oligomerization and conformation changes in the IL-2R CC subunits resulting in downstream signaling starting with CC phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate CC the receptor to form a docking site leading to the phosphorylation of CC several substrates including STAT5. This process leads to activation of CC several pathways including STAT, phosphoinositide-3-kinase/PI3K and CC mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell CC growth factor and can increase NK-cell cytolytic activity as well. CC Promotes strong proliferation of activated B-cells and subsequently CC immunoglobulin production. Plays a pivotal role in regulating the CC adaptive immune system by controlling the survival and proliferation of CC regulatory T-cells, which are required for the maintenance of immune CC tolerance. Moreover, participates in the differentiation and CC homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as CC well as memory CD8-positive T-cells. {ECO:0000256|RuleBase:RU363134}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU363134}. CC -!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000256|ARBA:ARBA00006949, CC ECO:0000256|RuleBase:RU363134}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ836354; ABH04319.1; -; mRNA. DR AlphaFoldDB; Q0PGS4; -. DR AGR; MGI:96548; -. DR MGI; MGI:96548; Il2. DR ChiTaRS; Il2; mouse. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005134; F:interleukin-2 receptor binding; IEA:InterPro. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR000779; IL-2. DR InterPro; IPR030477; IL-2_CS. DR PANTHER; PTHR48399; INTERLEUKIN-2; 1. DR PANTHER; PTHR48399:SF1; INTERLEUKIN-2; 1. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR SMART; SM00189; IL2; 1. DR SUPFAM; SSF47266; 4-helical cytokines; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130, KW ECO:0000256|RuleBase:RU363134}; KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU363134}; KW Disulfide bond {ECO:0000256|RuleBase:RU363134}; KW Growth factor {ECO:0000256|ARBA:ARBA00023030, KW ECO:0000256|RuleBase:RU363134}; KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|RuleBase:RU363134}; KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU363134}; KW Signal {ECO:0000256|ARBA:ARBA00022729}. FT REGION 1..25 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ABH04319.1" SQ SEQUENCE 149 AA; 17101 MW; C30D2C03A3F3E6E8 CRC64; APTSSPTSSP TSSSTAEAQQ QQQQQQHLEQ LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV DFLRRWIAFC QSIISTSPQ //