ID Q0PGS4_MOUSE Unreviewed; 149 AA. AC Q0PGS4; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 05-SEP-2006, sequence version 1. DT 02-JUN-2021, entry version 66. DE RecName: Full=Interleukin-2 {ECO:0000256|ARBA:ARBA00019453, ECO:0000256|RuleBase:RU363134}; DE Short=IL-2 {ECO:0000256|RuleBase:RU363134}; DE Flags: Fragment; GN Name=Il2 {ECO:0000313|MGI:MGI:96548}; GN Synonyms=IL2 {ECO:0000256|RuleBase:RU363134}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABH04319.1}; RN [1] {ECO:0000313|EMBL:ABH04319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:ABH04319.1}; RA Chantajorn S., Hongprayoon R., Songserm T.; RT "Cloning, expression and purification of mouse interleukin 2 and its RT biological activity."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Produced by T-cells in response to antigenic or mitogenic CC stimulation, this protein is required for T-cell proliferation and CC other activities crucial to regulation of the immune response. CC {ECO:0000256|RuleBase:RU363134}. CC -!- FUNCTION: Produced by T-cells in response to antigenic or mitogenic CC stimulation, this protein is required for T-cell proliferation and CC other activities crucial to regulation of the immune response. Can CC stimulate B-cells, monocytes, lymphokine-activated killer cells, CC natural killer cells, and glioma cells. CC {ECO:0000256|ARBA:ARBA00002436}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|RuleBase:RU363134}. CC -!- SIMILARITY: Belongs to the IL-2 family. {ECO:0000256|ARBA:ARBA00006949, CC ECO:0000256|RuleBase:RU363134}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ836354; ABH04319.1; -; mRNA. DR MGI; MGI:96548; Il2. DR ChiTaRS; Il2; mouse. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005134; F:interleukin-2 receptor binding; IEA:InterPro. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR000779; IL-2. DR InterPro; IPR030477; IL-2_CS. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR SMART; SM00189; IL2; 1. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130, KW ECO:0000256|RuleBase:RU363134}; Cytokine {ECO:0000256|RuleBase:RU363134}; KW Disulfide bond {ECO:0000256|RuleBase:RU363134}; KW Growth factor {ECO:0000256|RuleBase:RU363134}; KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|RuleBase:RU363134}; KW Secreted {ECO:0000256|RuleBase:RU363134}. FT REGION 1..25 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:ABH04319.1" SQ SEQUENCE 149 AA; 17101 MW; C30D2C03A3F3E6E8 CRC64; APTSSPTSSP TSSSTAEAQQ QQQQQQHLEQ LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV DFLRRWIAFC QSIISTSPQ //