ID Q0PGS4_MOUSE Unreviewed; 149 AA. AC Q0PGS4; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 05-SEP-2006, sequence version 1. DT 15-MAR-2017, entry version 53. DE RecName: Full=Interleukin-2 {ECO:0000256|RuleBase:RU363134}; DE Short=IL-2 {ECO:0000256|RuleBase:RU363134}; DE Flags: Fragment; GN Name=Il2 {ECO:0000313|MGI:MGI:96548}; GN Synonyms=IL2 {ECO:0000256|RuleBase:RU363134}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABH04319.1}; RN [1] {ECO:0000313|EMBL:ABH04319.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c {ECO:0000313|EMBL:ABH04319.1}; RA Chantajorn S., Hongprayoon R., Songserm T.; RT "Cloning, expression and purification of mouse interleukin 2 and its RT biological activity."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Produced by T-cells in response to antigenic or CC mitogenic stimulation, this protein is required for T-cell CC proliferation and other activities crucial to regulation of the CC immune response. {ECO:0000256|RuleBase:RU363134}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU363134}. CC -!- SIMILARITY: Belongs to the IL-2 family. CC {ECO:0000256|RuleBase:RU363134}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ836354; ABH04319.1; -; mRNA. DR UniGene; Mm.14190; -. DR STRING; 10090.ENSMUSP00000029275; -. DR PaxDb; Q0PGS4; -. DR MGI; MGI:96548; Il2. DR eggNOG; ENOG410J049; Eukaryota. DR eggNOG; ENOG41119SF; LUCA. DR HOVERGEN; HBG007496; -. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR012351; 4_helix_cytokine_core. DR InterPro; IPR000779; IL-2. DR InterPro; IPR030477; IL-2_CS. DR PANTHER; PTHR10078:SF32; PTHR10078:SF32; 1. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR ProDom; PD003649; Interleukin-2; 1. DR SMART; SM00189; IL2; 1. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|RuleBase:RU363134}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytokine {ECO:0000256|RuleBase:RU363134}; KW Disulfide bond {ECO:0000256|RuleBase:RU363134}; KW Growth factor {ECO:0000256|RuleBase:RU363134}; KW Immunity {ECO:0000256|RuleBase:RU363134}; KW Secreted {ECO:0000256|RuleBase:RU363134}. FT COILED 18 48 {ECO:0000256|SAM:Coils}. FT NON_TER 1 1 {ECO:0000313|EMBL:ABH04319.1}. SQ SEQUENCE 149 AA; 17101 MW; C30D2C03A3F3E6E8 CRC64; APTSSPTSSP TSSSTAEAQQ QQQQQQHLEQ LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV DFLRRWIAFC QSIISTSPQ //