ID Q0PGS4_MOUSE Unreviewed; 149 AA. AC Q0PGS4; DT 05-SEP-2006, integrated into UniProtKB/TrEMBL. DT 05-SEP-2006, sequence version 1. DT 24-JUL-2013, entry version 38. DE SubName: Full=Interleukin 2; DE Flags: Fragment; GN Name=Il2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=BALB/c; RA Chantajorn S., Hongprayoon R., Songserm T.; RT "Cloning, expression and purification of mouse interleukin 2 and its RT biological activity."; RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ836354; ABH04319.1; -; mRNA. DR IPI; IPI00649409; -. DR UniGene; Mm.14190; -. DR MGI; MGI:96548; Il2. DR HOVERGEN; HBG007496; -. DR InParanoid; Q0PGS4; -. DR Genevestigator; Q0PGS4; -. DR GO; GO:0005615; C:extracellular space; IDA:MGI. DR GO; GO:0005125; F:cytokine activity; IDA:MGI. DR GO; GO:0005134; F:interleukin-2 receptor binding; IDA:MGI. DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0002903; P:negative regulation of B cell apoptotic process; ISO:MGI. DR GO; GO:0050728; P:negative regulation of inflammatory response; IMP:MGI. DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; IMP:MGI. DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; IDA:MGI. DR GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:MGI. DR GO; GO:0051024; P:positive regulation of immunoglobulin secretion; IMP:MGI. DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IDA:MGI. DR GO; GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IMP:MGI. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. DR GO; GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IDA:MGI. DR GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IMP:MGI. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR012351; 4_helix_cytokine_core. DR InterPro; IPR000779; Interleukin-2. DR PANTHER; PTHR11443; PTHR11443; 1. DR Pfam; PF00715; IL2; 1. DR PRINTS; PR00265; INTERLEUKIN2. DR ProDom; PD003649; Interleukin-2; 1. DR SMART; SM00189; IL2; 1. DR SUPFAM; SSF47266; 4_helix_cytokine; 1. DR PROSITE; PS00424; INTERLEUKIN_2; 1. PE 2: Evidence at transcript level; FT NON_TER 1 1 SQ SEQUENCE 149 AA; 17101 MW; C30D2C03A3F3E6E8 CRC64; APTSSPTSSP TSSSTAEAQQ QQQQQQHLEQ LLMDLQELLS RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL RHVLDLTQSK SFQLEDAENF ISNIRVTVVK LKGSDNTFEC QFDDESATVV DFLRRWIAFC QSIISTSPQ //